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Laminin, beta 1

CLM, LAMB1, laminin beta 1
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: HAD, CAN, ACID, SET, SLAM
Papers on CLM
A physiologically based model of vascular refilling during ultrafiltration in hemodialysis.
Kotanko et al., Quezon, Philippines. In J Theor Biol, Mar 2016
Patient specific parameters are identified based on hematocrit (Hct) measurements by the Crit-Line monitor (CLM).
Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice.
Coligan et al., Rockville, United States. In Cell Death Differ, Feb 2016
CD300f (CLM-1) is a phosphatidylserine receptor known to positively regulate efferocytosis by macrophages, and CD300f gene-deficient mice are predisposed to develop a lupus-like disease.
Subspecies distribution and macrolide and fluoroquinolone resistance genetics of Mycobacterium abscessus in Korea.
Kim et al., Seoul, South Korea. In Int J Tuberc Lung Dis, Jan 2016
The minimal inhibitory concentrations (MICs) of clarithromycin (CLM) and ciprofloxacin (CFX) were determined using Sensititre™ RAPMYCO plates.
Receptor Dissociation and B-Cell Activation.
Reth et al., Freiburg, Germany. In Curr Top Microbiol Immunol, Dec 2015
Although dominant for a long time, the cross-link model (CLM) of BCR activation is not supported by recent studies of the nanoscale organization of the BCR on the surface of resting B cells.
Impact of somatic mutations on patterns of metastasis in colorectal cancer.
Yaeger et al., New York City, United States. In J Gastrointest Oncol, Dec 2015
In patients who undergo resection of colorectal liver metastases (CLM) with curative intent, KRAS mutation is associated increased risk of recurrence, worse survival, and increased recurrence outside of the liver, particularly in the lung, but also in the brain and bone.
Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner.
Mariman et al., Maastricht, Netherlands. In Genes Nutr, Nov 2015
Regression analyses provided us with six significant SNPs associated with the WMS in males: 3 SNPs in the POSTN gene and a SNP in the LAMB1, COL23A1, and FBLN5 genes.
Genes involved in regulation of intestinal permeability and their role in ulcerative colitis.
Buening et al., Berlin, Germany. In J Dig Dis, Nov 2015
AIM: Genome-wide association studies identified single-nucleotide polymorphisms in genes that might influence intestinal barrier function (HNF4A, ECM1, CDH1 and LAMB1) to increase the risk for ulcerative colitis (UC).
Carbon Cost of Plant Nitrogen Acquisition: Global Carbon Cycle Impact from An Improved Plant Nitrogen Cycle in the Community Land Model.
Phillips et al., Pasadena, United States. In Glob Chang Biol, Nov 2015
Here, we integrated a plant productivity-optimized nutrient acquisition model-the Fixation and Uptake of Nitrogen (FUN) model-into one of the most widely used TBMs, the Community Land Model (CLM).
Inflammatory Response After Laparoscopic Versus Open Resection of Colorectal Liver Metastases: Data From the Oslo-CoMet Trial.
Edwin et al., Belgium. In Medicine (baltimore), Oct 2015
The aim of the current study was to compare the inflammatory response after laparoscopic and open resection of colorectal liver metastases (CLM) in a randomized controlled trial.This was a predefined exploratory substudy within the Oslo CoMet-study.
Meta-analysis of KRAS mutations and survival after resection of colorectal liver metastases.
Vauthey et al., Houston, United States. In Br J Surg, Sep 2015
Recent reports have provided evidence that KRAS mutation status has prognostic value in patients with resectable colorectal liver metastases (CLM) irrespective of treatment with chemotherapy or anti-EGFR therapy.
Tumor Cell Adhesion As a Risk Factor for Sentinel Lymph Node Metastasis in Primary Cutaneous Melanoma.
Suman et al., Rochester, United States. In J Clin Oncol, Sep 2015
RESULTS: ITGB3, LAMB1, PLAT, and TP53 expression were associated with SLN metastasis.
Anti-EGFR and anti-VEGF agents: important targeted therapies of colorectal liver metastases.
Xu et al., Shanghai, China. In World J Gastroenterol, 2014
Colorectal liver metastasis (CLM) is common worldwide.
The tumour biology of synchronous and metachronous colorectal liver metastases: a systematic review.
Tekkis et al., London, United Kingdom. In Clin Exp Metastasis, 2013
Forty to fifty percent of colorectal cancer (CRC) patients develop colorectal liver metastases (CLM) that are either synchronous or metachronous in presentation.
Forced expression of laminin beta1 in podocytes prevents nephrotic syndrome in mice lacking laminin beta2, a model for Pierson syndrome.
Miner et al., Saint Louis, United States. In Proc Natl Acad Sci U S A, 2011
These results suggest the possibility that up-regulation of LAMB1 in podocytes, should it become achievable, would likely lessen the severity of nephrotic syndrome in patients carrying LAMB2 mutations.
The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.
Shibuya et al., Tsukuba, Japan. In J Exp Med, 2011
DAP12-coupled MAIR-II negatively regulates B cell-mediated adaptive immune responses.
HNF4α and CDH1 are associated with ulcerative colitis in a Dutch cohort.
Weersma et al., Groningen, Netherlands. In Inflamm Bowel Dis, 2011
We did not find an association of rs6949033 (LAMB1) with ulcerative colitis.
Expression of laminin β1 and integrin α2 in the anterior temporal neocortex tissue of patients with intractable epilepsy.
Tang et al., Nanning, China. In Int J Neurosci, 2011
Laminin beta1 and integrin alpha2 expression is elevated in the anterior temporal neocortex tissue from patients with intractable epilepsy.
Downregulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers.
Miyazaki et al., Yokohama, Japan. In Cancer Sci, 2011
results suggest that Lm3B11/3B21 may be required for normal mature vessels and interfere with tumor angiogenesis
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
Strachan et al., In Nat Genet, 2009
LAMB1 new susceptibility loci for ulcerative colitis
The renal glomerulus of mice lacking s-laminin/laminin beta 2: nephrosis despite molecular compensation by laminin beta 1.
Merlie et al., Saint Louis, United States. In Nat Genet, 1995
S-laminin/laminin beta 2, a homologue of the widely distributed laminin B1/beta 1 chain, is a major component of adult renal glomerular basement membrane (GBM).
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