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CDC-like kinase 1

Clk, Sty, CLK1, ST6GalNAc III
This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] (from NCBI)
Top mentioned proteins: CLOCK, p58, CAN, ACID, CDC2
Papers using Clk antibodies
Automated recordings of bioluminescence with special reference to the analysis of circadian rhythms
Stemple Derek, In PLoS Biology, 1999
... Madison, Wisconsin, United States), before western blotting (BioRad, Hercules, California, United States) using an anti-mouse CLK (Santa Cruz Biotechnology, Santa Cruz, California, United ...
Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing
Spector David L. et al., In The Journal of Cell Biology, 1987
... PCR was used to generate restriction sites at the start codon of murine Clk/STY1 and Clk/STY1 (K190R) cDNAs for convenient subcloning into pEGFP-C3 (CLONTECH Laboratories, Inc.) ...
Papers on Clk
An epigenetic signal encoded protection mechanism is activated by graphene oxide to inhibit its induced reproductive toxicity in Caenorhabditis elegans.
Wang et al., Nanjing, China. In Biomaterials, Feb 2016
For the underlying molecular mechanism of reproductive toxicity of GO, we raised a signaling cascade of HUS-1/CLK-2-CEP-1-EGL-1-CED-4-CED-3 to explain the roles of core apoptosis signaling pathway and DNA damage checkpoints.
Differences in GFR and Tissue Oxygenation, and Interactions between Stenotic and Contralateral Kidneys in Unilateral Atherosclerotic Renovascular Disease.
Textor et al., Rochester, United States. In Clin J Am Soc Nephrol, Feb 2016
Contralateral kidney (CLK) GFR declined in the stent group (43.6±19.7 to 36.6±19.5 ml/min; P=0.03).
Overexpression of the S100A2 protein as a prognostic marker for patients with stage II and III colorectal cancer.
Sugihara et al., Tokyo, Japan. In Int J Oncol, Feb 2016
Stage II and III CRC tissue mRNA expression was profiled using an Affymetrix Gene Chip, and copy number profiles of 125 patients were generated using an Affymetrix 250K Sty array.
Benzobisthiazoles Represent a Novel Scaffold for Kinase Inhibitors of CLK Family Members.
Ketteler et al., London, United Kingdom. In Biochemistry, Feb 2016
We propose models for binding of these compounds to CLK family proteins and key residues in CLK2 that are important for the compound interactions and the kinase activity.
A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.
Whitmarsh et al., In Nat Cell Biol, Jun 2015
The monooxygenase CLK-1 (human homologue COQ7) was previously reported to be mitochondrial, with a role in respiration and longevity.
Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment.
Du et al., Beijing, China. In Molecules, 2014
Cdc2-like kinase 1 (CLK1) in the host cells is responsible for alternative splicing of the M2 gene of influenza virus during influenza infection and replication.
Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells.
McKnight et al., Dallas, United States. In Science, 2014
Hydrogel binding was reversed upon phosphorylation of the SR domain by CDC2-like kinases 1 and 2 (CLK1/2).
Human CDC2-like kinase 1 (CLK1): a novel target for Alzheimer's disease.
Trivedi et al., Bhopāl, India. In Curr Drug Targets, 2014
The CLK family consists of four isoforms namely CLK1, CLK2, CLK3 and CLK4.
Reversal of slow growth and heartbeat through the restoration of mitochondrial function in clk-1-deficient mouse embryos by exogenous administration of coenzyme Q10.
Shirasawa et al., Tokyo, Japan. In Exp Gerontol, 2012
The results indicate that clk-1 regulates growth and heart rates through CoQ-mediated mitochondrial functions in mouse embryos.
Identification of selective inhibitors of cdc2-like kinases 1 and 4 (Clk1, Clk4)
Aubé et al., Bethesda, United States. In Unknown Journal, 2012
The reported compounds are low-nanomolar Clk and Dyrk inhibitors, with the most potent compound having IC50s <10 nM against Clk1, Clk4, Dyrk1A and Dyrk1B.
Exploration of chemical space based on 4-anilinoquinazoline.
Zhu et al., Nanjing, China. In Curr Med Chem, 2011
Most of the compounds have been proved to be EGFR/HER2 kinase inhibitors, binding at the hinge region of the ATP site and some lead compounds have been optimized against a number of different kinases, including VEGFR-2, Src, Aurora A/B, Tpl, Clk and PDE10A.
Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor.
Hagiwara et al., Kyoto, Japan. In J Cell Biol, 2011
Clk1/4 expression induced by stress-responsive splicing serves to maintain the phosphorylation state of SR proteins.
Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy.
Cochrane et al., Toronto, Canada. In Retrovirology, 2010
CLK1 Increases While CLK2 Decreases HIV-1 Gene Expression.
Molecular genetic analysis of circadian timekeeping in Drosophila.
Hardin, College Station, United States. In Adv Genet, 2010
The per feedback loop, or core loop, is interlocked with the Clock (Clk) feedback loop, but whether the Clk feedback loop contributes to circadian timekeeping is not known.
The aging-associated enzyme CLK-1 is a member of the carboxylate-bridged diiron family of proteins.
Lippard et al., Cambridge, United States. In Biochemistry, 2010
Analyses of the in vitro activity of MCLK1 with quinone substrates revealed that NADH can serve directly as a reductant for catalytic activation of dioxygen and substrate oxidation
Regulation and differential role of the tissue factor isoforms in cardiovascular biology.
Rauch et al., Berlin, Germany. In Trends Cardiovasc Med, 2010
Several factors are involved in this regulatory mechanism, such as serine/arginine-rich (SR) proteins, the Cdc2-like kinase (Clk) family, the dual-specificity tyrosine phosphorylation regulated kinases, the SR protein kinases (SRPK) 1 and 2, the protein kinase B (PKB,Akt), and the DNA topoisomerase I (DNA topo I).
Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication.
Meyer et al., Berlin, Germany. In Nature, 2010
We also show that a small molecule inhibitor of CDC-like kinase 1 (CLK1) reduces influenza virus replication by more than two orders of magnitude, an effect connected with impaired splicing of the viral M2 messenger RNA.
Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
Rauch et al., Berlin, Germany. In Circ Res, 2009
Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability.
Boulton et al., London, United Kingdom. In Nat Cell Biol, 2007
Here, we show that the human homologue of the Caenorhabditis elegans biological clock protein CLK-2 (HCLK2) associates with the S-phase checkpoint components ATR, ATRIP, claspin and Chk1.
A role for casein kinase 2alpha in the Drosophila circadian clock.
Allada et al., Evanston, United States. In Nature, 2003
For example, the Drosophila proteins Clock (Clk) and Cycle (Cyc) activate transcription of period (per) and timeless (tim).
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