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Chloride intracellular channel 3

CLIC3, chloride intracellular channel 3
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CLIC1, HAD, H1, CLIC5, Rab25
Papers on CLIC3
Transcriptional over-expression of chloride intracellular channels 3 and 4 in malignant pleural mesothelioma.
Zarogiannis et al., Lárisa, Greece. In Comput Biol Chem, Dec 2015
RESULTS: In MPM, the gene expressions of CLIC3 and CLIC4 were significantly increased compared to controls (p=0.001
Epigenetic screening of salivary gland mucoepidermoid carcinoma identifies hypomethylation of CLIC3 as a common alteration.
Ha et al., Shenyang, China. In Oral Oncol, Dec 2015
Bisulfite sequencing was used to validate these results, with subsequent quantitative Methylation-Specific PCR (qMSP) to validate chloride intracellular channel protein 3 (CLIC3) in a separate cohort.
RNA sequencing reveals differentially expressed genes as potential diagnostic and prognostic indicators of gallbladder carcinoma.
Gao et al., Shanghai, China. In Oncotarget, Sep 2015
Besides, we observed a positive correlation between serum CA19-9 concentration and the expression levels of TNNT1, MMP9 and CLIC3.
Individual bovine in vitro embryo production and cumulus cell transcriptomic analysis to distinguish cumulus-oocyte complexes with high or low developmental potential.
Sirard et al., Québec, Canada. In Theriogenology, Feb 2015
Higher expression of 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9) (lipid metabolism), Chloride intracellular channel 3 (CLIC3), Keratin 8 (KRT8), and Lumican (LUM) (molecular transport) was observed in CC-2-8-cells (P < 0.05).
CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer.
Norman et al., Glasgow, United Kingdom. In J Cell Sci, 2014
Chloride intracellular channel 3 (CLIC3) drives invasiveness of pancreatic and ovarian cancer by acting in concert with Rab25 to regulate the recycling of α5β1 integrin from late endosomes to the plasma membrane.
Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis.
Van Criekinge et al., Amsterdam, Netherlands. In J Pathol, 2013
For 12 genes (CLIC3, CREB3L1, FAM19A4, LFNG, LHX1, MRC2, NKX2-8, NPTX-1, PHACTR3, PRDM14, SOST and TNFSF13) specific methylation in HPV-containing cell lines was confirmed by semi-quantitative methylation-specific PCR.
CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner.
Kwon et al., South Korea. In Eur J Immunol, 2013
Chloride intra-cellular channel 3 CLIC3, an intracellular chloride channel protein, was essential for CRIg-mediated LM killing by directly interacting with the cytoplasmic domain of CRIg, and the two proteins colocalized on the membranes of LM-containing vacuoles.
CLT1 targets bladder cancer through integrin α5β1 and CLIC3.
Pilch et al., Pittsburgh, United States. In Mol Cancer Res, 2013
Paralleling our previous results, we found CLT1-induced tumor cell death to be increased in the presence of fibronectin, which mediated CLT1 internalization and subsequent autophagic cell death in a mechanism that depends on tumor cell integrin α5β1 and chloride intracellular channel 3 (CLIC3).
The plasma membrane sialidase NEU3 regulates the malignancy of renal carcinoma cells by controlling β1 integrin internalization and recycling.
Venerando et al., Milano, Italy. In J Biol Chem, 2013
In addition, NEU3 silencing up-regulated the Ras-related protein RAB25, which directs internalized integrins to lysosomes, and down-regulated the chloride intracellular channel protein 3 (CLIC3), which induces the recycling of internalized integrins to the plasma membrane.
Placental CLIC3 is increased in fetal growth restriction and pre-eclampsia affected human pregnancies.
Gude et al., Australia. In Placenta, 2012
Previously, we described the expression profile of a member of the CLIC family of proteins, CLIC3, in human placentae and fetal membranes.
A genome-wide RNAi screen identifies novel targets of neratinib resistance leading to identification of potential drug resistant genetic markers.
Ryan et al., Cambridge, United States. In Mol Biosyst, 2012
CLIC3, TRAPPC2P1, P2RX2), protein ubiquitination (e.g.
Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.
Norman et al., Glasgow, United Kingdom. In Dev Cell, 2012
This requires CLIC3, a protein upregulated in Rab25-expressing cells and tumors, which colocalizes with active α5β1 in late endosomes/lysosomes.
Structure of human CLIC3 at 2 A resolution.
Curmi et al., Amsterdam, Netherlands. In Proteins, 2010
The structure of the soluble form of CLIC3, is presented.
[Changes of proteomics in the injured lung of adult rats subjected to acrolein inhalation].
Zhang et al., Kunming, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2010
Among them, tyrosine 3/tryptophan 5-monooxygenase activation protein, phosphatidylinositol transfer protein, poly(A)-binding protein, presented a marked upregulation, while 2601 and 2603 vimentin, phosphatidylinositol transfer protein, and chloride intracellular channel 3 showed a marked downregulation.
Proteome differences of placenta between pre-eclampsia and normal pregnancy.
Kamali-Sarvestani et al., Shīrāz, Iran. In Placenta, 2010
Among them, four proteins (chloride intracellular channel 3, apolipoprotein A-I, transthyretin (TTR) and protein disulphide isomerase) were up-regulated while seven (peroxiredoxin 2, peroxiredoxin 3, Hsc 70, Cu/Zn-superoxide dismutase (SOD-1), actin gamma 1 propeptide, chain A of enoyl-coenzyme A hydratase and HSP gp96) showed decreased expression in PE in comparison with normal placentas.
Expression and cellular localisation of chloride intracellular channel 3 in human placenta and fetal membranes.
Gude et al., Australia. In Placenta, 2007
CLIC3 facilitates chloride ion movement and regulates cellular processes associated with the movement of chloride in placental and fetal membrane cells.
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