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Claudin 8

claudin-8, CLDN8
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: claudin-1, Occludin, claudin-4, claudin-5, CAN
Papers on claudin-8
The Effects of Alcohol Intoxication and Burn Injury on the Expression of Claudins and Mucins in the Small and Large Intestines.
Choudhry et al., Maywood, United States. In Shock, Jan 2016
We observed >50% decrease in claudin-4 and claudin-8 genes in both ileal and colonic epithelial cells 1 day after injury.
Claudin expression in follicle-associated epithelium of rat Peyer's patches defines a major restriction of the paracellular pathway.
Amasheh et al., Saint Petersburg, Russia. In Acta Physiol (oxf), Jan 2016
Analysis of claudin expression and localization revealed a stronger expression of major sealing proteins in follicle-associated epithelium, including claudin-1, claudin-4, claudin-5 and claudin-8.
Tight Junction Ultrastructure Alterations in a Mouse Model of Enteral Nutrient Deprivation.
Teitelbaum et al., Ann Arbor, United States. In Dig Dis Sci, Jan 2016
These findings were correlated with the loss of TJ localization of claudin-4 and tricellulin, reduced expression of claudin-5 and claudin-8, and reduced ex vivo EBF.
Changes in the Expression and Distribution of Claudins, Increased Epithelial Apoptosis, and a Mannan-Binding Lectin-Associated Immune Response Lead to Barrier Dysfunction in Dextran Sodium Sulfate-Induced Rat Colitis.
Wang et al., Nanjing, China. In Gut Liver, Dec 2015
Compared with the controls, the expression of sealing claudins (claudin 3, claudin 5, and claudin 8) was significantly decreased, but that of claudin 1 was increased.
Claudin 8 Contributes to Malignant Proliferation in Human Osteosarcoma U2OS Cells.
Ding et al., Shanghai, China. In Cancer Biother Radiopharm, Nov 2015
This study is aimed to evaluate the role of Claudin 8 (CLDN8) in human OS.
Glucocorticoids Regulate Tight Junction Permeability of Lung Epithelia by Modulating Claudin 8.
Wittekindt et al., Ulm, Germany. In Am J Respir Cell Mol Biol, Nov 2015
Glucocorticoids up-regulated claudin 8 (cldn8) expression via glucocorticoid receptors.
Expression changes of cell-cell adhesion-related genes in colorectal tumors.
Siedlecki et al., Warsaw, Poland. In Oncol Lett, Jun 2015
Between these tissue types, differences were observed in the mRNA levels of genes encoding adherens junction proteins (upregulation of CDH3 and CDH11, and downregulation of CDH19 and PTPRF), tight junction proteins (upregulation of CLDN1 and CLDN2, and downregulation of CLDN5, CLDN8, CLDN23, CLDN15, JAM2 and CGN) and desmosomes (upregulation of DSC3 and DSG3, and downregulation of DSC2), in addition to a decrease in the expression of certain other genes involved in intercellular connections: PCDHB14, PCDH7, MUPCDH and NEO1.
RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications.
Guttman-Yassky et al., Denmark. In J Allergy Clin Immunol, May 2015
The common AD transcriptome identified by using both techniques contained 217 genes, including inflammatory (S100A8/A9/A12, CXCL1, and 2'-5'-oligoadenylate synthetase-like [OASL]) and barrier (MKi67, keratin 16 [K16], and claudin 8 [CLDN8]) AD-related genes.
KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8.
Hou et al., Saint Louis, United States. In Proc Natl Acad Sci U S A, May 2015
Here, we report the identification of claudin-8 as a previously unidentified physiologic target for KLHL3 and provide an alternative explanation for the collecting duct's role in PHA-II.
The complete functional recovery of chitosan-treated biomimetic hyperplastic and normoplastic urothelial models.
Kreft et al., Ljubljana, Slovenia. In Histochem Cell Biol, 2015
However, 3 weeks after chitosan treatment, TER was reestablished, tight junctions resealed, permeability decreased, and progressive differentiation stages of newly exposed superficial UCs expressing uroplakins and tight junction protein claudin-8 were found.
Expression of claudin-5, -7, -8 and -9 in cervical carcinoma tissues and adjacent non-neoplastic tissues.
Wang et al., Zibo, China. In Int J Clin Exp Pathol, 2014
The positive expression rates of claudin-8 in cervical carcinoma tissues and adjacent non-neoplastic tissues were 54.2 % and 27.8% respectively (P < 0.01).
Increased expression of renal TRPM6 compensates for Mg(2+) wasting during furosemide treatment.
Bindels et al., Nijmegen, Netherlands. In Clin Kidney J, 2012
Next, renal mRNA levels of the epithelial Mg(2+) channel (TRPM6), the Na(+), Cl(-) cotransporter (NCC), the epithelial Ca(2+) channel (TRPV5), the cytosolic Ca(2+)-binding protein calbindin-D28K, as well parvalbumin (PV), claudin-7 (CLDN7) and claudin-8 (CLDN8), the epithelial Na(+) channel (ENaC) and the Na(+)-H(+) exchanger 3 (NHE3) were determined by real-time quantitative polymerase chain reaction.
Regulation of paracellular transport in the distal nephron.
Hou, Saint Louis, United States. In Curr Opin Nephrol Hypertens, 2012
Histological studies have demonstrated the renal localization of claudin-3, claudin-4, claudin-7, and claudin-8 in the collecting duct.
Role of immunohistochemistry in diagnosing renal neoplasms: when is it really useful?
Lopez-Beltran et al., Houston, United States. In Arch Pathol Lab Med, 2012
CONCLUSIONS: Some of the most important and useful markers for the diagnosis of renal neoplasm include cytokeratins, vimentin, PAX2, PAX8, RCC marker, CD10, E-cadherin, kidney-specific cadherin, parvalbumin, claudin-7, claudin-8, α-methylacyl coenzyme A racemase, CD117, TFE3, thrombomodulin, uroplakin III, p63, CD57, and carbonic anhydrase IX.
Immunohistochemical diagnosis of renal neoplasms.
Shen et al., Houston, United States. In Arch Pathol Lab Med, 2011
CONCLUSIONS: The following markers may have diagnostic utility in various diagnostic contexts: cytokeratins, vimentin, α-methylacyl coenzyme A racemase, carbonic anhydrase IX, PAX2, PAX8, RCC marker, CD10, E-cadherin, kidney-specific cadherin, parvalbumin, claudin-7, claudin-8, S100A1, CD82, CD117, TFE3, thrombomodulin, uroplakin III, p63, and S100P.
Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization.
Waldegger et al., Saint Louis, United States. In Proc Natl Acad Sci U S A, 2010
data show that claudin-4 interacts with claudin-8 and that their association is required for the anion-selective paracellular pathway in the collecting duct
Immunohistochemical stain for cytokeratin 7, S100A1 and claudin 8 is valuable in differential diagnosis of chromophobe renal cell carcinoma from renal oncocytoma.
Choi et al., In Histopathology, 2009
the combination of CK7, S100A1 and claudin 8 immunohistochemistry can be useful for classifying tumours of overlapping histology as chromophobe renal cell carcinoma or renal oncocytomas.
Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.
Young et al., Atlanta, United States. In Hum Pathol, 2009
claudin-7 and claudin-8 have potential use as immunohistochemical biomarkers in the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma
Na+ absorption defends from paracellular back-leakage by claudin-8 upregulation.
Fromm et al., Berlin, Germany. In Biochem Biophys Res Commun, 2009
Na(+) absorption is paralleled by claudin-8-mediated sealing of the paracellular barrier to prevent Na(+) back-leakage, supporting steep Na(+) gradients in distal colon.
Differential expression of genes encoding tight junction proteins in colorectal cancer: frequent dysregulation of claudin-1, -8 and -12.
Buhr et al., Berlin, Germany. In Int J Colorectal Dis, 2007
Differential expression of genes encoding claudins in colorectal cancer suggests that these tight junction proteins may be associated to and involved in tumorigenesis.
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