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Claudin 7

claudin-1, claudin-7, CLDN1
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: Occludin, ZO-1, CAN, claudin-4, HAD
Papers using claudin-1 antibodies
Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: how the early phase impacts on outcomes
McKeating Jane A. et al., In Journal of Hepatology, 2008
... stomatitis virus glycoprotein (VSV G) (Abcam), anti-NS5A 9E10, anti-CD81 2s131, anti-SR-BI (BD Biosciences), anti-Occludin and Claudin-1 (Invitrogen), anti-HIF-1α (Novus Biologicals), anti-VEGF VG76e, and anti-HCV ...
Claudin-1, -2, -3, -4, -5, and -7 in usual interstitial pneumonia and sarcoidosis
Belej Kamil et al., In International Journal of Molecular Sciences, 2008
... antibodies: Snail-1 (rabbit polyclonal, Ab 85931, 1:150, Abcam), E-cadherin (mouse monoclonal, M3612, 1:50, Dako) and claudin-1 (mouse monoclonal, sc-81796, 1:500, Santa Cruz Biotechnology, Inc.) by an indirect ...
Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouse
Engelhardt Britta et al., In Acta Neuropathologica, 2000
... TRE-claudin-1 transgenic mice were then produced ...
Rapid detection of west nile virus from human clinical specimens, field-collected mosquitoes, and avian samples by a TaqMan reverse transcriptase-PCR assay.
Banfield Bruce W., In PLoS ONE, 1999
... The following primary antibodies were obtained from the following sources: claudin-1 specific mouse monoclonal antibodies used respectively for immunoprecipitation/immunoblotting and indirect immunofluorescence were from Invitrogen (Carlsbad, CA) and Santa Cruz Biotechnology (Santa Cruz, CA); mouse ...
Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells
Füllekrug Joachim et al., In The Journal of Cell Biology, 1998
... Other antibodies used were as follows: mouse anti–β1-integrin (Chemikon International), rabbit anti–claudin-1 (Zymed Laboratories), rabbit anti–α-tubulin (Santa Cruz Biotechnology, Inc.), mouse anti-transferrin receptor ...
Papers on claudin-1
Porcine lactoferrin-derived peptide LFP-20 protects intestinal barrier by maintaining tight junction complex and modulating inflammatory response.
Wang et al., Hangzhou, China. In Biochem Pharmacol, Feb 2016
LFP-20 increased the expression of zonula occludens-1, occludin and claudin-1 and reduced permeability as well as apoptosis of the colon in LPS-treated mice.
Segmental Differences in Radiation-Induced Alterations of Tight Junction-Related Proteins in Non-Human Primate Jejunum, Ileum and Colon.
Hauer-Jensen et al., Québec, Canada. In Radiat Res, Jan 2016
Claudin-1 was induced only in the colon on day 4 postirradiation.
Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier.
Rittner et al., Würzburg, Germany. In Biomaterials, Jan 2016
It is composed of a basal membrane and layers of perineurial cells sealed by tight junction proteins like claudin-1.
Altered expression levels of occludin, claudin-1 and myosin light chain kinase in the common bile duct of pediatric patients with pancreaticobiliary maljunction.
Wang et al., Suzhou, China. In Bmc Gastroenterol, Dec 2015
The expression of the tight junction-associated proteins occludin and claudin-1 in the epithelium was examined by immunohistochemistry.
Sirtuin and metabolic kidney disease.
Itoh et al., Tokyo, Japan. In Kidney Int, Oct 2015
This further decreases expression of Sirt1 in glomerular podocytes and increases expression of a tight junction protein, claudin-1, which results in albuminuria.
The Genetics and Epigenetics of Atopic Dermatitis-Filaggrin and Other Polymorphisms.
Lu et al., Changsha, China. In Clin Rev Allergy Immunol, Oct 2015
Mutations in the human filaggrin gene (FLG) are the most significant and well-replicated genetic mutation associated with AD, and other mutations associated with epidermal barriers such as SPINK5, FLG-2, SPRR3, and CLDN1 have all been linked to AD. Gene variants may also contribute to the abnormal innate and adaptive responses found in AD, including mutations in PRRs and AMPs, TSLP and TSLPR, IL-1 family cytokines and receptors genes, vitamin D pathway genes, FCER1A, and Th2 and other cytokines genes.
Claudins and pathogenesis of viral infection.
Baumert et al., Strasbourg, France. In Semin Cell Dev Biol, Jun 2015
Notable is the discovery of CLDN1 as an essential host factor for hepatitis C virus (HCV) entry, which led to detailed characterization of CLDN1 and its association with tetraspanin CD81 for the initiation of HCV infection.
Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody.
Baumert et al., Strasbourg, France. In Nat Biotechnol, May 2015
Using a human liver-chimeric mouse model, we show that a monoclonal antibody specific for the TJ protein claudin-1 (ref.
Changes in the phosphorylation of claudins during the course of experimental colitis.
Xia et al., Hefei, China. In Int J Clin Exp Pathol, 2014
In the present study, we found that the phosphorylated claudin-4 and claudin-7 contents were increased in experimental colitis at days 6 and 8, and colonic phosphorylated claudin-6 was found to be increased at day 4 and day 8. Colonic phosphorylated claudin-5 was found to be decreased at day 4 but increased at day 6.
Genes Regulating Epithelial Polarity Are Critical Suppressors of Esophageal Oncogenesis.
Ji et al., Xinxiang, China. In J Cancer, 2014
In particular, we reviewed the involvement of several critical genes, including Lkb1, claudin-4, claudin-7, Par3, Lgl1, E-cadherin, and the Scnn1 gene family.
Claudin 1 in Breast Cancer: New Insights.
Myal et al., Winnipeg, Canada. In J Clin Med, 2014
Claudin 1 is a small transmembrane protein responsible for maintaining the barrier function that exists between epithelial cells.
Transient opening of the perineurial barrier for analgesic drug delivery.
Rittner et al., Würzburg, Germany. In Proc Natl Acad Sci U S A, 2012
claudin-1 is the major sealing component in the perineurium, and could be modulated to facilitate drug delivery or, potentially, reseal the barrier under pathological conditions.
Claudin-1, claudin-2 and claudin-11 genes differentially associate with distinct types of anti-inflammatory macrophages in vitro and with parasite- and tumour-elicited macrophages in vivo.
Van Ginderachter et al., Brussels, Belgium. In Scand J Immunol, 2012
we identified Cldn1, Cldn2 and Cldn11 as genes that discriminate between diverse types of M2 macrophages
Histopathologic and ultrastructural features and claudin expression in papillary tumors of the pineal region: a multicenter analysis.
Jouvet et al., Lyon, France. In Am J Surg Pathol, 2012
Claudin expression may help in the diagnosis of papillary tumors of the pineal region and can be used in combination with other markers.
Increased claudin-1 protein expression in hepatic metastatic lesions of colorectal cancer.
Shirouzu et al., Kurume, Japan. In Anticancer Res, 2012
These observations suggest that CL-1 plays a pivotal role in the regulation of cellular morphology and in the behavior of metastatic processes in colorectal cancer
Determinants contributing to claudin ion channel formation.
Krause et al., Berlin, Germany. In Ann N Y Acad Sci, 2012
suggests that primarily S53 and potentially D68 in Cld-1 are involved in sealing of the paracellular cleft and that charge-unselective pores may be induced by substituting S53E.
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.
Baumert et al., Strasbourg, France. In Nat Med, 2011
The identified receptor tyrosine kinases (RTKs) mediate HCV entry by regulating CD81-claudin-1 co-receptor associations and viral glycoprotein-dependent membrane fusion.
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells.
Rice et al., New York City, United States. In Nature, 2009
4), scavenger receptor class B type I (SR-BI, also known as SCARB1) and claudin-1 (CLDN1).
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry.
Rice et al., New York City, United States. In Nature, 2007
CLDN1 is required for HCV infection of human hepatoma cell lines and is the first factor to confer susceptibility to HCV when ectopically expressed in non-hepatic cells
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria.
Ricciardi-Castagnoli et al., Milano, Italy. In Nat Immunol, 2001
In addition, because DCs express tight-junction proteins such as occludin, claudin 1 and zonula occludens 1, the integrity of the epithelial barrier is preserved.
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