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CDC28 protein kinase regulatory subunit 2

CKS2, ckshs2, CDC28 protein kinase regulatory subunit 2
CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CDC2, CAN, Cks1, POLYMERASE
Papers on CKS2
Depletion of Cks1 and Cks2 expression compromises cell proliferation and enhance chemotherapy-induced apoptosis in HepG2 cells.
Zhang et al., Xiamen, China. In Oncol Rep, Jan 2016
The present study explored the oncogenic roles of overexpressed Cks1 and Cks2 in human hepatocellular carcinoma cells.
New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals.
Birchmeier et al., Berlin, Germany. In Gut, Aug 2015
RESULTS: Three new genes from the colorectal cancer (CRC) metastasis signature, BOP1, CKS2 and NFIL3, were identified as direct transcription targets of β-catenin/TCF4.
Gene expression patterns combined with network analysis identify hub genes associated with bladder cancer.
Ding et al., Jinan, China. In Comput Biol Chem, Jun 2015
Hub genes of complex networks, such as UBE2C, ACTA2, FABP4, CKS2, FN1 and TOP2A, were also obtained according to analysis of degree.
CKS2 in human cancers: Clinical roles and current perspectives (Review).
Zhang et al., Xiamen, China. In Mol Clin Oncol, May 2015
UNASSIGNED: Cyclin-dependent kinase subunit 2 (CKS2) is indicated in the processes of cell cycle and cell proliferation.
Transcriptomic correlates of organ failure extent in sepsis.
Tamayo et al., Valladolid, Spain. In J Infect, May 2015
RESULTS: The expression levels of a group of genes participating in the cell cycle (HIST1H1C, CKS2, CCNA2, CDK1, CCNB2, CIT, CCNB1, AURKA, RAD51), neutrophil protease activity (ELANE, ADORA3, MPO, MMP8, CTSG), IL-1R and IL-18R response correlated directly with SOFA and mortality.
Cks overexpression enhances chemotherapeutic efficacy by overriding DNA damage checkpoints.
Spruck et al., Los Angeles, United States. In Oncogene, May 2015
Cdc kinase subunit (Cks) proteins Cks1 and Cks2 are adaptor-like proteins that bind many cyclin-dependent kinases.
Up-regulated CKS2 promotes tumor progression and predicts a poor prognosis in human colorectal cancer.
Zhong et al., Shanghai, China. In Am J Cancer Res, 2014
Cyclin-dependent kinases regulatory subunit 2 (CKS2) is a cyclin-dependent kinase-interacting protein, which is essential for cell cycle regulation.
CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Endicott et al., Oxford, United Kingdom. In Nat Commun, 2014
Here we report the crystal structures of complexes of CDK1-Cks1 and CDK1-cyclin B-Cks2.
Clinical and biological impact of cyclin-dependent kinase subunit 2 in esophageal squamous cell carcinoma.
Natsugoe et al., Kagoshima, Japan. In Oncol Rep, 2014
Cyclin-dependent kinase subunit 2 (CKS2) is a cyclin-dependent kinase subunit (CKS) family member that participates in cell cycle regulation.
Expression of cyclin kinase subunit 2 in human breast cancer and its prognostic significance.
Tan et al., Guangzhou, China. In Int J Clin Exp Pathol, 2013
Cyclin kinase subunit 2 (CKS2) protein is a small cyclin-dependent kinase-interacting protein, which is essential for the first metaphase/anaphase transition of mammalian meiosis.
Expression and clinical significance of cyclin kinase subunit 2 in colorectal cancer.
Qiao et al., Shanghai, China. In Oncol Lett, 2013
The overexpression of cyclin kinase subunit 2 (CKS2) is tightly correlated with tumor aggressiveness and prognosis in various malignancies, including gastric, breast, liver and prostate cancer.
[Long-term expansion of multipotent mesenchymal stromal cells under reduced oxygen tension].
Buravkova et al., In Tsitologiia, 2012
However, genome-wide analysis of MMSC gene expression level revealed changes in expression of cyclins (CCND2 and PCNA), regulatory subunit cyclin-dependent kinase (CKS2) and an inhibitor of cyclin-dependent kinase (CDKN2C), regulating the cell cycle, which is obviously facilitated the increase in the proliferative capacity of cells at lower oxygen tension.
The CDK subunit CKS2 counteracts CKS1 to control cyclin A/CDK2 activity in maintaining replicative fidelity and neurodevelopment.
Yu et al., London, United Kingdom. In Dev Cell, 2012
Cks2(-/-) cortical progenitor cells are limited in their capacity to differentiate into mature neurons, a phenotype akin to animals lacking p27
Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins.
Reed et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2012
Overexpression of Cks1 or Cks2 in human mammary epithelial and breast cancer-derived cells, as well as in other cell types, leads to override of the intra-S-phase checkpoint.
Clinicopathological and biological significance of CDC28 protein kinase regulatory subunit 2 overexpression in human gastric cancer.
Mori et al., Beppu, Japan. In Int J Oncol, 2011
CKS2 is one of the gastric cancer-related genes that correlates with biological aggressiveness and poor prognosis of gastric cancer.
Cyclin-dependent kinase-associated protein Cks2 is associated with bladder cancer progression.
Xu et al., Shanghai, China. In J Int Med Res, 2010
The Cks2 gene may have potential as a biomarker for predicting superficial bladder cancer progression to muscle-invasive cancer.
DNA microarray analysis identifies CKS2 and LEPR as potential markers of meningioma recurrence.
Finocchiaro et al., Milano, Italy. In Oncologist, 2010
Study calculated DeltaCt values of CKS2 and LEPR and found that their differential expression (C-L index) was significantly higher in grade I than in grade II or III meningiomas.
Clinical, pathological, proliferative and molecular responses associated with neoadjuvant aromatase inhibitor treatment in breast cancer.
Miller, Edinburgh, United Kingdom. In J Steroid Biochem Mol Biol, 2010
In terms of molecular events, aromatase inhibitor treatment is associated with changes in expression of genes classically associated with oestrogen regulation (KIAA0101, ZWINT, IRS1 and TFF1) and cell cycle progression, most notably mitotic phase proteins (CDC2, CCNB1 and CKS2).
Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis.
Reed et al., Los Angeles, United States. In Science, 2003
mice lacking Cks2 were viable but sterile in both sexes; Cks2 is required for the first metaphase/anaphase transition of meiosis
p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase.
Beach et al., New York City, United States. In Cell, 1995
In many transformed cells, p21 disappears, and a substantial fraction of cyclin A-CDK2 complexes with p9CKS1/CKS2, p19, and p45.
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