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Keratin 4

CK4, keratin 4, K-4, cytokeratin 4, KRT4, CYK-4
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cytokeratin, CAN, cytokeratin 8, cytokeratin 19, K14
Papers on CK4
Ex vivo construction of a novel model of bioengineered bladder mucosa: A preliminary study.
Garzón et al., Granada, Spain. In Int J Urol, Jan 2016
After 7 days of ex vivo development, the epithelial layer expressed pancytokeratin, and cytokeratins CK7, CK8 and CK13, as well as filaggrin and ZO-2, with negative expression of CK4 and uroplakin III.
Potential candidate cells for constructing tissue-engineered lacrimal duct epithelium: a histological and cytological study in rabbits.
Cui et al., Hangzhou, China. In J Zhejiang Univ Sci B, Nov 2015
Hematoxylin and eosin staining and immunohistochemical staining of cytokeratin AE1+AE3, cytokeratin 4, Ki-67, and MUC5AC were observed by light microscopy.
The effect of energy balance on the transcriptome of bovine granulosa cells at 60 days postpartum.
Sirard et al., Québec, Canada. In Theriogenology, Nov 2015
Genes linked with cellular organization (KRT4 and PPL), proliferation (TACSTD2), and fatty acids metabolism (VNN2) were downregulated in granulosa cells from animals with severe NEB.
Localized juvenile spongiotic gingival hyperplasia possibly originates from the junctional gingival epithelium-an immunohistochemical study.
Naidu et al., Tel Aviv-Yafo, Israel. In Histopathology, Aug 2015
AIMS: To immunohistochemically evaluate the cytokeratin (CK) pattern of expression in localized juvenile spongiotic gingival hyperplasia (LJSGH) as compared with the gingival epithelium (GE).
Human Umbilical Cord Lining Cells as Novel Feeder Layer for Ex Vivo Cultivation of Limbal Epithelial Cells.
Reza et al., Singapore, Singapore. In Invest Ophthalmol Vis Sci, Jul 2015
Expression of cytokeratins CK14, CK15, CK19, CK3, and CK4 was further compared.
Gene and miRNA expression changes in squamous cell carcinoma of larynx and hypopharynx.
Panda et al., Bengaluru, India. In Genes Cancer, Jul 2015
We found that matrix metalloproteinases along with SCEL, CRNN, KRT4, SPINK5, and TGM3 among others have significantly altered expression in these tumors.
Recent advances in the treatment of hormone receptor positive HER2 negative metastatic breast cancer.
Cinieri et al., Brindisi, Italy. In Crit Rev Oncol Hematol, Jun 2015
In the last years many targeted agents have been investigated to prevent or overcome endocrine resistance; only a few of them have been found effective in HR positive MBC, such as everolimus, CK4/6 inhibitors and HDAC inhibitors.
Current approaches to the diagnosis and treatment of white sponge nevus.
Liu et al., Shanghai, China. In Expert Rev Mol Med, 2014
The genes associated with WSN include mutant cytokeratin keratin 4 (KRT4) and keratin 13 (KRT13).
Reconstruction of conjunctival epithelium-like tissue using a temperature-responsive culture dish.
Fu et al., Shanghai, China. In Mol Vis, 2014
Immunohistochemistry for CK4, CK19, and MUC5AC showed the cell sheets still maintained characteristics of the conjunctival epithelium.
The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis.
Glotzer et al., Chicago, United States. In Elife, 2014
Centralspindlin, composed of the Rho family GTPase-activating protein (RhoGAP) MgcRacGAP/CYK-4 and the kinesin MKLP1/ZEN-4, is known to activate ECT-2, but the underlying mechanism is not understood.
Centralspindlin: at the heart of cytokinesis.
Glotzer et al., Chicago, United States. In Cytoskeleton (hoboken), 2012
At the heart of cytokinesis in animal cells is the centralspindlin complex which is composed of two proteins, a kinesin-like protein, Mitotic kinesin-like protein 1, and a Rho GTPase activating protein (RhoGAP), CYK-4.
Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: a clue for histopathogenesis.
Yamaguchi et al., Tokyo, Japan. In Histopathology, 2011
The aberrant expression of K4 and K13 and concomitant up-regulation of the other keratins may be one of the causative factors for morphological alterations in the affected epithelium.
Fascin and CK4 as biomarkers for esophageal squamous cell carcinoma.
Taylor et al., Bethesda, United States. In Anticancer Res, 2011
Fascin has a potential role as an early detection biomarker and CK4 as a tumor marker in esophageal squamous cell carcinoma.
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.
Glotzer et al., Chicago, United States. In Plos Biol, 2009
Failure to phosphorylate HsCyk-4 blocks Ect2 recruitment to the central spindle and the subsequent induction of furrowing.
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.
Jallepalli et al., New York City, United States. In Plos Biol, 2009
Data found that Plk1 binds and directly phosphorylates the HsCYK-4 at the midzone and this modification creates a major docking site for the tandem BRCT repeats of the Rho GTP exchange factor Ect2.
Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis.
Oegema et al., Eugene, United States. In Science, 2009
Centralspindlin, a protein complex consisting of the kinesin-6 ZEN-4 and the Rho family GTPase activating protein (GAP) CYK-4, is required for central spindle assembly and cytokinesis in Caenorhabditis elegans.
The C. elegans pharynx: a model for organogenesis.
Mango, Salt Lake City, United States. In Wormbook, 2006
Rather, the kinesin ZEN-4/MKLP1 and CYK-4/RhoGAP are critical to establish the apical domain during epithelial polarization.
CYK-4/GAP provides a localized cue to initiate anteroposterior polarity upon fertilization.
Mango et al., Salt Lake City, United States. In Science, 2006
Here we present evidence that RhoA, the guanine nucleotide-exchange factor ECT-2, and the Rho guanosine triphosphatase-activating protein CYK-4 modulate myosin light-chain activity to create a gradient of actomyosin, which establishes the anterior domain.
Cell cycle regulation of central spindle assembly.
Glotzer et al., Vienna, Austria. In Nature, 2004
Central spindle assembly requires the centralspindlin complex composed of the Caenorhabditis elegans ZEN-4 (mammalian orthologue MKLP1) kinesin-like protein and the Rho family GAP CYK-4 (MgcRacGAP).
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