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Citrate synthase

citrate synthase
The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, fibrillin-1, AGE
Papers on citrate synthase
Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled study.
Wadley et al., Australia. In Free Radic Biol Med, Feb 2016
Antioxidant concentrations, citrate synthase activity and protein abundances of sodium-dependent vitamin C transporter 2 (SVCT2), total Akt and phosphorylated Akt (ser473) were also measured in muscle samples.
MH84: A Novel γ-Secretase Modulator/PPARγ Agonist-Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer's Disease.
Eckert et al., Frankfurt am Main, Germany. In Neurochem Res, Jan 2016
MH84 protects against nitrosative stress, increased mitochondrial respiration, citrate synthase (CS) activity and protein levels of PGC1α indicating enhanced mitochondrial content at nano-molar concentrations.
Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles.
Milsom et al., Vancouver, Canada. In Biol Lett, Jan 2016
We found that brain mitochondria from anoxia-acclimated turtles exhibited a unique phenotype of remodelling relative to normoxic controls, including: (i) decreased citrate synthase and F1FO-ATPase activity but maintained protein content, (ii) markedly reduced aerobic capacity, and (iii) mild uncoupling of the mitochondrial proton gradient.
N-terminal arm of orchardgrass Hsp17.2 (DgHsp17.2) is essential for both in vitro chaperone activity and in vivo thermotolerance in yeast.
Son et al., Chinju, South Korea. In Arch Biochem Biophys, Jan 2016
Its function in in vitro chaperone properties has shown in protecting the model substrate, malate dehydrogenase (MDH) and citrate synthase (CS).
Quantitative proteomics analysis to identify diffuse axonal injury biomarkers in rats using iTRAQ coupled LC-MS/MS.
Li et al., Chongqing, China. In J Proteomics, Jan 2016
Of the ten candidate DAI biomarkers, four proteins, citrate synthase (CS), synaptosomal-associated protein 25 (Snap25), microtubule-associated protein 1B (MAP1B) and Rho-associated protein kinase 2 (Rock2), were validated by subsequent Western blot and immunohistochemistry analyses.
Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle.
Kibbey et al., New Haven, United States. In Cell Metab, Dec 2015
In INS-1 cells, citrate synthase rates correlated with both insulin secretion and oxygen consumption.
Oxidative stress participates in quadriceps muscle dysfunction during the initiation of osteoarthritis in rats.
Jou et al., Tainan City, Taiwan. In Int J Clin Exp Pathol, 2014
Quadriceps muscle dysfunction was evaluated by assessing muscular interleukin-6, citrate synthase activity, and myosin heavy chain IIa mRNA expression levels.
Can we optimise the exercise training prescription to maximise improvements in mitochondria function and content?
Eynon et al., Australia. In Biochim Biophys Acta, 2014
MAJOR CONCLUSIONS: The results of cross-sectional studies, as well as training studies involving rats and humans, suggest that training intensity may be an important determinant of improvements in mitochondrial function (as determined by mitochondrial respiration), but not mitochondrial content (as assessed by citrate synthase activity).
Egg activation in physiological polyspermy.
Iwao, Yamaguchi, Japan. In Reproduction, 2012
We introduced a novel soluble sperm factor for egg activation, sperm-specific citrate synthase, into polyspermic newt eggs to cause Ca(2+) waves.
Metabolic control and regulation of the tricarboxylic acid cycle in photosynthetic and heterotrophic plant tissues.
Fernie et al., Germany. In Plant Cell Environ, 2012
Our studies suggest that citrate synthase, aconitase, isocitrate dehydrogenase, succinyl CoA ligase, succinate dehydrogenase, fumarase and malate dehydrogenase have control coefficients flux for respiration of -0.4,
Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα).
Burris et al., Jupiter, United States. In Plos One, 2011
Citrate synthase (CS) is a direct RORalpha target gene and one mechanism by which RORalpha regulates lipid metabolism is via regulation of CS expression.
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans.
Schrauwen et al., Wageningen, Netherlands. In Cell Metab, 2011
In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1α protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate.
Mitochondrial dysfunction in autism.
Pessah et al., Davis, United States. In Jama, 2011
RESULTS: The reduced nicotinamide adenine dinucleotide (NADH) oxidase activity (normalized to citrate synthase activity) in lymphocytic mitochondria from children with autism was significantly lower compared with controls (mean, 4.4 [95% confidence interval {CI}, 2.8-6.0]
Intracellular acetyl unit transport in fungal carbon metabolism.
Distel et al., Amsterdam, Netherlands. In Eukaryot Cell, 2010
In fungi, two systems for acetyl unit transport have been identified: a shuttle dependent on the carrier carnitine and a (peroxisomal) citrate synthase-dependent pathway.
Identification and characterization of the mitochondrial targeting sequence and mechanism in human citrate synthase.
Chang et al., Tainan City, Taiwan. In J Cell Biochem, 2009
These results provide an important basis for the study of mitochondrial dysfunction due to aberrant CSa trafficking.
Role of adiponectin in human skeletal muscle bioenergetics.
Smith et al., Baton Rouge, United States. In Cell Metab, 2006
Adiponectin treatment of human myotubes in primary culture induces mitochondrial biogenesis, palmitate oxidation, and citrate synthase activity, and reduces the production of reactive oxygen species.
Detection of citrate synthase-reacting autoantibodies after heart transplantation: an epitope mapping study.
Berki et al., Budapest, Hungary. In Transpl Int, 2005
possible role of CS-specific autoantibodies in the pathomechanism of allograft vasculopathy
Enhanced citrate synthase activity in human pancreatic cancer.
Swierczynski et al., Gdańsk, Poland. In Pancreas, 2005
It is likely that enhanced citrate synthase activity contributes to the conversion of glucose to lipids in pancreatic cancer providing substrate for membrane lipids synthesis.
Citrate synthase expression and enzyme activity after endurance training in cardiac and skeletal muscles.
Alway et al., Morgantown, United States. In J Appl Physiol, 2003
Responses of skeletal and cardiac muscles in CS activity and gene expression at 1 and 48 h after endurance training. Acute effect of exercise on training-induced elevation in CS activity in rat soleus but not ventricle muscles.
Flight of Winter Moths Near 0{degrees}C.
Mommsen et al., In Science, 1985
However, the temperature characteristics of citrate synthase and pyruvate kinase from both of these different kinds of moths and from a sphinx moth that flies with a muscles temperature of 40 degrees C are nearly identical.
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