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Suppressor of cytokine signaling 2

cis-2, SOCS2
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] (from NCBI)
Top mentioned proteins: CIs, ACID, SOCS3, V1a, CAN
Papers on cis-2
Suppressor of cytokine signaling 2 modulates the immune response profile and development of experimental cerebral malaria.
Machado et al., Belo Horizonte, Brazil. In Brain Behav Immun, Feb 2016
Suppressor of cytokine signaling 2 (SOCS2), an intracellular protein induced by cytokines and hormones, modulates the immune response, neural development, neurogenesis and neurotrophic pathways.
SOCS2 Balances Metabolic and Restorative Requirements During Liver Regeneration.
Karp et al., United States. In J Biol Chem, Jan 2016
A screen for candidates revealed suppressor of cytokine signaling 2 (SOCS2), an inhibitor of growth hormone (GH) signaling, was strongly induced after partial hepatectomy.
Synthetic and reactivity studies of hetero-tri-anionic sodium zincates.
O'Hara et al., Glasgow, United Kingdom. In Dalton Trans, Jan 2016
By reacting with cis-DMP(H) (cis-2,6-dimethylpiperidine), the zincate could thermodynamically function as an amide base, to give the transamination product (TMEDA)Na(μ-cis-DMP)(μ-(n)Bu)Zn(t)Bu , although no crystals could be grown.
A Point Mutation in Suppressor of Cytokine Signalling 2 (Socs2) Increases the Susceptibility to Inflammation of the Mammary Gland while Associated with Higher Body Weight and Size and Higher Milk Production in a Sheep Model.
Tosser-Klopp et al., France. In Plos Genet, Dec 2015
After implementing genome-wide association studies, we identified a major QTL associated with SCC on ovine chromosome 3. Fine mapping of the region, using full sequencing with 12X coverage in three animals, provided one strong candidate SNP that mapped to the coding sequence of a highly conserved gene, suppressor of cytokine signalling 2 (Socs2).
SOCS2: physiological and pathological functions.
Haan et al., Luxembourg, Luxembourg. In Front Biosci (elite Ed), Dec 2015
The most studied family members, CIS, SOCS1, SOCS2 and SOCS3 are important regulators of the JAK-STAT pathway.
The DSF Family of Cell-Cell Signals: An Expanding Class of Bacterial Virulence Regulators.
Dow et al., Dundee, United Kingdom. In Plos Pathog, Jul 2015
Signal molecules of the diffusible signal factor (DSF) family are cis-2-unsaturated fatty acids.
Comparative perspective and synthetic applications of transition metal mediated oxidative cyclisation of 1,5-dienes towards cis-2,5-disubstituted tetrahydrofurans.
Sheikh, Saudi Arabia. In Org Biomol Chem, 2015
cis-2,5-Disubstituted tetrahydrofurans constitute the core of several natural products and synthetic analogues which exhibit a broad and interesting range of biological activities.
Control of Biofilms with the Fatty Acid Signaling Molecule cis-2-Decenoic Acid.
Sauer et al., Binghamton, United States. In Pharmaceuticals (basel), 2014
Recently however, it has been demonstrated that Pseudomonas aeruginosa produces a small messenger molecule cis-2-decenoic acid (cis-DA) that shows significant promise as an effective adjunctive to antimicrobial treatment of biofilms.
Targeted Analysis Reveals an Important Role of JAK-STAT-SOCS Genes for Milk Production Traits in Australian Dairy Cattle.
Williamson et al., Sydney, Australia. In Front Genet, 2014
Gene expression studies using qRT-PCR revealed differential expression of SOCS2, SOCS4, and SOCS5 genes across the lactation cycle in dairy cows.
Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif.
Huang et al., Harbin, China. In Nature, 2014
Interactions of the smaller domain (α-domain) of Vif with ELOC and CUL5 are cooperative and mimic those of SOCS2 with the latter two proteins.
Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player.
Turnley et al., Melbourne, Australia. In Front Mol Neurosci, 2013
Some members of the family, and in particular SOCS2, have roles in the nervous system that at least partially overlap with that of neurotrophins, namely neuronal differentiation and neurite outgrowth.
SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice.
Flores-Morales et al., Copenhagen, Denmark. In Faseb J, 2012
This study identified SOCS2 as an important regulator of hepatic homeostasis under conditions of high-fat dietary stress.
Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease.
Machado et al., Belo Horizonte, Brazil. In Am J Pathol, 2012
SOCS2 plays a role in modulating heart damage and function in a murine model of acute Chagas disease.
LPS regulates SOCS2 transcription in a type I interferon dependent autocrine-paracrine loop.
Winqvist et al., Stockholm, Sweden. In Plos One, 2011
LPS regulates SOCS2 transcription in a type I interferon dependent autocrine-paracrine loop.
SOCS2-induced proteasome-dependent TRAF6 degradation: a common anti-inflammatory pathway for control of innate immune responses.
Aliberti et al., Cincinnati, United States. In Plos One, 2011
SOCS2-induced proteasome-dependent TRAF6 degradation is a common anti-inflammatory pathway for control of innate immune responses.
Expression of SOCS1, SOCS2, and SOCS3 in growth hormone-stimulated skin fibroblasts from children with idiopathic short stature.
Fernando et al., Santiago, Chile. In J Pediatr Endocrinol Metab, 2011
High SOCS2 is associated with idiopathic short stature.
CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance.
Fajas et al., Montpellier, France. In Cell Metab, 2009
CXCL5 blocks insulin signaling by activating the Jak2/STAT5/SOCS2 pathway.
Ylide-initiated michael addition-cyclization reactions beyond cyclopropanes.
Tang et al., Shanghai, China. In Acc Chem Res, 2008
Telluronium allylides react with aromatic N-phenyl aldimines to give trans-vinylaziridines and with chiral N- tert-butylsulfinylimines to afford the optically active cis-2-substituted vinylaziridines, both with high diastereoselectivities.
Evolution of the Petasis-Ferrier union/rearrangement tactic: construction of architecturally complex natural products possessing the ubiquitous cis-2,6-substituted tetrahydropyran structural element.
Razler et al., Philadelphia, United States. In Acc Chem Res, 2008
The frequent low abundance of architecturally complex natural products possessing significant bioregulatory properties mandates the development of rapid, efficient, and stereocontrolled synthetic tactics, not only to provide access to the biologically rare target but also to enable elaboration of analogues for the development of new therapeutic agents with improved activities and/or pharmacokinetic properties.
Sex pheromones produced by male boll weevil: isolation, identification, and synthesis.
Minyard et al., In Science, 1969
Compound I is (+)-cis-2-isopropenyl-l-methylcyclobtutaneethanol; II, cis-3,3-dimethiyl->(1,beta)cyclohexaneethanol; III, cis-3,3-dimethlyl->(1,alpha)-cyclohexaneacetaldehyde; and IV, trans-3,3-dimethyl->(1,alpha)-cyclohexanecetaldehyde.
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