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TAF9 RNA polymerase II, TATA box binding protein

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p21, PCNA, Kip, NOV, CAN
Papers using CIP antibodies
Sulfite reduction in mycobacteria
Bertozzi Carolyn R. et al., In Biochemistry, 2006
... Restriction enzymes and calf intestinal alkaline phosphatase (CIP) were from New England Biolabs (Ipswich, MA) ...
Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals.
Bridger Joanna Mary, In PLoS ONE, 2004
... All DNA manipulations were performed using restriction enzymes, T4 DNA ligase, CIP, and buffers according to standard procedures and manufacturer's instructions (Life Technologies, Inc., Roche and New ...
Development of luteinizing hormone releasing hormone neurones
Vetter Monica L et al., In Neural Development, 2000
... Madison, WI, USA) to generate blunt ends followed by dephosphorylation of the 3' ends with CIP (New England Biolabs, Ipswich, MA, USA) ...
Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins.
Rutherford Suzannah, In PLoS ONE, 1997
... following which the full length construct was excised using NheI, blunted with Calf Intestinal Phosphatase (CIP)(New England Biolabs, NEB) and NotI and ...
Isolation and characterization of the hyperthermostable serine protease, pyrolysin, and its gene from the hyperthermophilic archaeon Pyrococcus furiosus
Yamabhai Montarop et al., In BMC Biotechnology, 1995
... Restriction endonucleases, T4 DNA ligase, and calf intestinal phosphatase (CIP) were purchased from New England Biolabs (New England Biolabs, Ipswich, ...
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Papers on CIP
p38 MAPK Participates in the Mediation of GLT-1 Up-regulation During the Induction of Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning.
Li et al., Shijiazhuang, China. In Mol Neurobiol, Feb 2016
UNASSIGNED: Our previous study has proved that the up-regulation of glial glutamate transporter 1 (GLT-1) played an important role in the acquisition of brain ischemic tolerance after cerebral ischemic preconditioning (CIP) in rats.
Regulation of BmBDV NS1 by phosphorylation: Impact of mutagenesis at consensus phosphorylation sites on ATPase activity and cytopathic effects.
Yao et al., Zhenjiang, China. In J Invertebr Pathol, Jan 2016
After wild-type NS1 was treated with calf intestinal alkaline phosphatase (CIP), ATPase activity decreased significantly.
Bacillus cucumis sp. nov. isolated from the rhizosphere of cucumber (Cucumis sativa).
McInroy et al., Vienna, Austria. In Int J Syst Evol Microbiol, Jan 2016
nov., with AP-6T (= CIP 110974T = CCM 8651T) as the type strain.
p27(Kip1) expression as a prognostic marker for squamous cell carcinoma of the head and neck.
García-García et al., A Coruña, Spain. In Oncol Lett, Nov 2015
The aim of the current study is to provide a literature review on the association between p27(Kip1) expression and the clinical and pathological aspects of head and neck squamous cell carcinoma (HNSCC), and the expression of other CDKIs of the Cip/Kip family and cyclins.
Transcriptional regulator PRDM12 is essential for human pain perception.
Senderek et al., Cambridge, United Kingdom. In Nat Genet, Jul 2015
New therapeutic options have recently been derived from studies of individuals with congenital insensitivity to pain (CIP).
The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.
Larsson et al., Erlangen, Germany. In Physiol Rev, Jul 2015
Critical illness polyneuropathies (CIP) and myopathies (CIM) are common complications of critical illness.
Cellular Response upon Stress: p57 Contribution to the Final Outcome.
Antonangeli et al., Roma, Italy. In Mediators Inflamm, 2014
p57 is a cyclin-dependent kinase inhibitor belonging to the CIP/KIP family and is a well-known regulator of the cell cycle during embryogenesis and tissue differentiation.
Metalloproteinases and Their Tissue Inhibitors in Comparison between Different Chronic Pneumopathies in the Horse.
Gehlen et al., Berlin, Germany. In Mediators Inflamm, 2014
Using a scoring system, 61 horses were classified controls as free of respiratory disease (n = 15), recurrent airway obstruction (RAO, n = 17), inflammatory airway disease (IAD, n = 18), or chronic interstitial pneumopathy (CIP, n = 11).
Protein kinase C involvement in cell cycle modulation.
Follo et al., Bologna, Italy. In Biochem Soc Trans, 2014
In particular, the targets of PKCs resulted to be some of the key proteins involved in the cell cycle including cyclins, cyclin-dependent kinases (Cdks), Cip/Kip inhibitors and lamins.
Coordination of proliferation and neuronal differentiation by the retinoblastoma protein family.
Ajioka, Tokyo, Japan. In Dev Growth Differ, 2014
In this review, the coordination of cell cycle control and neuronal differentiation during development are discussed, focusing on regulation by the Rb family of tumor suppressors (including p107 and p130), and the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitors.
Case Report: Neuropathic pain in a patient with congenital insensitivity to pain.
Woods et al., Cambridge, United Kingdom. In F1000res, 2013
We report a unique case of a woman with Channelopathy-associated Insensitivity to Pain (CIP) Syndrome, who developed features of neuropathic pain after sustaining pelvic fractures and an epidural hematoma that impinged on the right fifth lumbar (L5) nerve root.
[Interactions of proliferation and differentiation signaling pathways in myogenesis].
Grzelkowska-Kowalczyk et al., Warsaw, Poland. In Postepy Hig Med Dosw (online), 2013
At the molecular level, several key regulators of the cell cycle have been identified: cyclin-dependent kinases and their cyclins stimulate the cell cycle progress and its arrest is determined by the activity of cdk inhibitors (Cip/Kip and INK protein families) and pocket protein family: Rb, p107 and p130.
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma.
Bae et al., Ch'ŏngju, South Korea. In Cancer Cell, 2013
A functional genetic screen of a fly mutant library and molecular analysis in cultured cell lines revealed that Runx3 forms a complex with BRD2 in a K-Ras-dependent manner in the early phase of the cell cycle; this complex induces expression of p14(ARF)/p19(Arf) and p21(WAF/CIP).
CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors.
Mello et al., Worcester, United States. In Cell, 2013
Piwi-interacting (pi) RNAs are germline-expressed small RNAs linked to epigenetic programming.
TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.
Romier et al., Illkirch-Graffenstaden, France. In J Biol Chem, 2012
TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.
p57 is required for quiescence and maintenance of adult hematopoietic stem cells.
Nakayama et al., Fukuoka, Japan. In Cell Stem Cell, 2011
Members of the Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors (p21, p27, p57) have been implicated in HSC quiescence, but loss of p21 or p27 in mice affects HSC quiescence or functionality only under conditions of stress.
Multiple hTAF(II)31-binding motifs in the intrinsically unfolded transcriptional activation domain of VP16.
Han et al., Taejŏn, South Korea. In Bmb Rep, 2009
Multiple hTAF(II)31-binding motifs in the intrinsically unfolded transcriptional activation domain of VP16.
Distinct modes of gene regulation by a cell-specific transcriptional activator.
Bieker et al., New York City, United States. In Proc Natl Acad Sci U S A, 2009
TAF9 functionally supports EKLF activity by enhancing its ability to activate the beta-globin gene. TAF9 interacts with a conserved beta-globin downstream promoter element
STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation.
Martinez et al., Riverside, United States. In Mol Cell Biol, 2008
suggest a novel STAF65gamma-dependent function of STAGA-type complexes in cell proliferation and transcription activation by MYC postloading of TFIID and RNA polymerase II that involves direct recruitment of core Mediator
Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus.
Lamond et al., Nicosia, Cyprus. In J Biol Chem, 2005
hCINAP is a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus
More papers using CIP antibodies
Yeast pheromone receptor endocytosis and hyperphosphorylation are independent of G protein-mediated signal transduction
Riezman Howard et al., In The Journal of Cell Biology, 1991
... (Mannheim, Germany) and calf intestinal alkaline phosphatase (CIP) was from New England Biolabs Inc. ...
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