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Cell death-inducing DFFA-like effector a

CIDEA, cell death-inducing DFFA-like effector A
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: ACID, UCP1, Insulin, ICAD, HAD
Papers on CIDEA
Differential Roles of CIDE Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes.
Zhou et al., Taiwan. In J Biol Chem, Feb 2016
CIDE proteins including Cidea, Cideb and Cidec (also called Fsp27) play important roles in lipid metabolism.
Berry intake changes hepatic gene expression and DNA methylation patterns associated with high-fat diet.
Holm et al., Lund, Sweden. In J Nutr Biochem, Jan 2016
Cfd, Cidea, Crat) and lipid and cholesterol biosynthesis, which is in line with the exacerbation of HF-induced hepatic steatosis in these mice.
Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation.
Korach et al., United States. In Plos One, Dec 2015
Furthermore, the expression of Cidea/CIDEA that has been shown to regulate milk lipid secretion in the mammary gland was reduced in hNAG-1 mammary glands.
The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix.
Christian et al., London, United Kingdom. In Elife, Dec 2015
CIDEA is a lipid droplet (LD)-protein enriched in brown adipocytes promoting the enlargement of LDs which are dynamic, ubiquitous organelles specialized for storing neutral lipids.
The role of peptidylarginine deiminase 4 in ovarian cancer cell tumorigenesis and invasion.
Chang et al., Jinan, China. In Tumour Biol, Dec 2015
PCR arrays of A2780 cells treated with PADI4-siRNA revealed the up-regulated expression of six genes, including cell death-inducing DFFA-like effector a (CIDEA) and tumor necrosis factor receptor superfamily member 9 (TNFRSF9), and the down-regulation of seven genes, including integrin beta 3 (ITGB3) and BCL2-antagonist/killer 1 (BAK1).
Gene expression of peripheral blood mononuclear cells is affected by cold exposure.
Palou et al., Palma, Spain. In Am J Physiol Regul Integr Comp Physiol, Nov 2015
Of particular interest, PBMCs reflected adipose tissue-increased Cpt1a mRNA expression in response to cold (in older animals) and browning induction occurring in rWAT of young animals (1 mo) characterized by increased Cidea expression and by the appearance of a high number of multilocular CIDE-A positive adipocytes.
Structural insight into CIDE domains: the Janus face of CIDEs.
Park, Kyŏngsan, South Korea. In Apoptosis, Feb 2015
Several other CIDE-containing proteins, CIDE-A, CIDE-B, and CIDE-3, have since been identified in humans.
β-Hydroxybutyrate Facilitates Fatty Acids Synthesis Mediated by Sterol Regulatory Element-Binding Protein1 in Bovine Mammary Epithelial Cells.
Li et al., In Cell Physiol Biochem, 2014
Sterol regulatory element-binding protein1 (SREBP1) and cell death-inducing DNA fragmentation factor-alpha-like effector α (Cidea) play crucial roles in lipid synthesis.
Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue.
Blüher et al., Göteborg, Sweden. In Sci Rep, 2014
We found increased expression of cell death-inducing DFFA-like effector a (CIDEA), involved in formation of lipid droplets in both fat depots in response to significant weight loss.
The developmental transition of ovine adipose tissue through early life.
Symonds et al., Nottingham, United Kingdom. In Acta Physiol (oxf), 2014
Subsequently, within 12 h of birth, the depot was largely depleted of lipid and expression of genes such as UCP1, PGC1α, CIDEA peaked.
CIDE proteins and lipid metabolism.
Li et al., Beijing, China. In Arterioscler Thromb Vasc Biol, 2012
Cell death-inducing DNA fragmentation factor 45-like effector family proteins, including Cidea, Cideb, and Fsp27 (Cidec), are emerging as important regulators of various lipid metabolic pathways and play pivotal roles in the development of metabolic disorders.
Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids.
Li et al., Beijing, China. In Nat Med, 2012
acts as transcriptional coactivator of C/EBPbeta in mammary glands to control lipid secretion
Suppression of FoxO1/cell death-inducing DNA fragmentation factor α-like effector A (Cidea) axis protects mouse β-cells against palmitic acid-induced apoptosis.
Murakami et al., Tochigi, Japan. In Mol Cell Endocrinol, 2012
Cidea is a critical regulator of free fatty acid-induced apoptosis as a novel downstream target for Foxo1 in pancreatic beta-cells
Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2-dependent pathways in human adipocytes.
Murakami et al., Tochigi, Japan. In J Lipid Res, 2011
Insulin regulates CIDEA and CIDEC expression via PI3K, and it regulates expression of each protein via Akt1/2-and JNK2-dependent pathways, respectively, in human adipocytes.
Role of nuclear receptor corepressor RIP140 in metabolic syndrome.
Parker et al., London, United Kingdom. In Biochim Biophys Acta, 2011
Moreover, white adipocytes with targeted disruption of RIP140 express genes characteristic of brown fat including CIDEA and UCP1 while skeletal muscles show a shift in fibre type composition enriched in more oxidative fibres.
CIDEA interacts with liver X receptors in white fat cells.
Laurencikiene et al., Huddinge, Sweden. In Febs Lett, 2011
CIDEA binds to liver X receptors and regulates their activity in vitro.
Association of the cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population.
Hua et al., Beijing, China. In Diabetes Res Clin Pract, 2011
The proportion of subjects with CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population was significantly higher based on genotype, in the order: GG
Which CIDE are you on? Apoptosis and energy metabolism.
Inoko et al., Japan. In Mol Biosyst, 2011
Around 1998, cell death-inducing DNA fragmentation factor-alpha (DFFA)-like effector (CIDE) proteins including CIDEA, CIDEB and CIDEC/fat specific protein 27 (Fsp27) were first identified by their sequence homology with the N-terminal domain of the DNA fragmentation factor (DFF).
Cidea-deficient mice have lean phenotype and are resistant to obesity.
Li et al., Singapore, Singapore. In Nat Genet, 2003
a role for Cidea in regulating energy balance and adiposity
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