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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Capicua homolog

Top mentioned proteins: CAN, ACID, EGFR, V1a, Insulin
Papers on Cic
EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes.
Edgar et al., Heidelberg, Germany. In Plos Genet, Dec 2015
Here we demonstrate that the HMG-box transcriptional repressor, Capicua (Cic), mediates these functions of EGFR signaling.
Mapping the binding interface of ERK and transcriptional repressor Capicua using photocrosslinking.
Link et al., Princeton, United States. In Proc Natl Acad Sci U S A, Aug 2015
One of these substrates, Capicua (Cic), is a transcriptional repressor that was first identified in Drosophila and has been implicated in a number of human diseases.
Expression of citrate carrier gene is activated by ER stress effectors XBP1 and ATF6α, binding to an UPRE in its promoter.
Siculella et al., Lecce, Italy. In Biochim Biophys Acta, 2015
The cytosolic pool of acetyl-CoA is mainly derived from the activity of mitochondrial citrate carrier (CiC).
Origins of context-dependent gene repression by capicua.
Jiménez et al., Barcelona, Spain. In Plos Genet, 2015
The HMG-box protein Capicua (Cic) is a transcriptional repressor that is downregulated in response to RTK signaling, thereby enabling RTK-dependent induction of Cic targets.
Deficiency of Capicua disrupts bile acid homeostasis.
Lee et al., South Korea. In Sci Rep, 2014
Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown.
Characterization of Bbx, a member of a novel subfamily of the HMG-box superfamily together with Cic.
Lv et al., Chengdu, China. In Dev Genes Evol, 2014
In this work, phylogenetic analysis showed that BBX is highly conserved and belongs to a novel subfamily of HMG-Box superfamily together with CIC (capicua homolog).
Capicua is involved in Dorsal-mediated repression of zerknüllt expression in Drosophila embryo.
Hong et al., South Korea. In Bmb Rep, 2014
Here, we present evidence that Capicua (Cic) is involved in Dl-mediated repression in the zerknüllt (zen) ventral repression element (VRE).
Mitochondrial tricarboxylate and dicarboxylate-tricarboxylate carriers: from animals to plants.
Capobianco et al., Cosenza, Italy. In Iubmb Life, 2014
The citrate carrier (CiC), characteristic of animals, and the dicarboxylate-tricarboxylate carrier (DTC), characteristic of plants and protozoa, belong to the mitochondrial carrier protein family whose members are responsible for the exchange of metabolites, cofactors, and nucleotides between the cytoplasm and the mitochondrial matrix.
Epidermal growth factor receptor tyrosine kinase (EGFR-TK) mutation testing in adults with locally advanced or metastatic non-small cell lung cancer: a systematic review and cost-effectiveness analysis.
Kleijnen et al., Maastricht, Netherlands. In Health Technol Assess, 2014
'Assumption of equal prognostic value' approach: the lowest total strategy cost was [commercial-in-confidence (CiC) information has been removed] [Sanger sequencing or Roche cobas EGFR Mutation Testing Kit(®) (Roche Molecular Systems, Inc., Branchburg, NJ, USA)] compared with (CiC information has been removed) for the most expensive strategy (fragment length analysis combined with pyrosequencing).
Kinetics of gene derepression by ERK signaling.
Shvartsman et al., Princeton, United States. In Proc Natl Acad Sci U S A, 2013
ERK induces ind by antagonizing its repression by Capicua (Cic), a transcription factor that acts as a sensor of receptor tyrosine kinases in animal development and human diseases.
Capicua regulates proliferation and survival of RB-deficient cells in Drosophila.
Moon et al., Montréal, Canada. In Biol Open, 2013
Here, we report that Capicua (Cic), an HMG box transcription factor whose activity is regulated by the EGFR/Ras pathway, regulates both proliferation and survival of RB-deficient cells in Drosophila.
Torso RTK controls Capicua degradation by changing its subcellular localization.
Wieschaus et al., Princeton, United States. In Development, 2012
The transcriptional repressor Capicua (Cic) controls multiple aspects of Drosophila embryogenesis and has been implicated in vertebrate development and human diseases.
EGFR-dependent downregulation of Capicua and the establishment of Drosophila dorsoventral polarity.
Jiménez et al., Barcelona, Spain. In Fly (austin), 2012
We have characterized the transcriptional circuit that links EGFR signaling to pipe repression: in dorsal follicle cells, the homeodomain transcription factor Mirror (Mirr), which is induced by EGFR signaling, directly represses pipe transcription, whereas in ventral follicle cells, the HMG-box protein Capicua (Cic) supports pipe expression by repressing mirr.
CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas.
Hartmann et al., Heidelberg, Germany. In Acta Neuropathol, 2012
Found CIC and FUBP1 mutations in oligodendrogliomas and demonstrate the presence of these mutations in oligoastrocytomas.
Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers.
Marra et al., Canada. In J Pathol, 2012
Our detailed study of genetic aberrations in oligodendroglioma suggests a functional interaction between CIC mutation, IDH1/2 mutation, and 1p/19q co-deletion
Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua.
Zoghbi et al., Houston, United States. In Science, 2011
mechanism by which constitutive reduction of Cic rescues Spinocerebellar ataxia type 1
Mutations in CIC and FUBP1 contribute to human oligodendroglioma.
Kinzler et al., Baltimore, United States. In Science, 2011
CIC gene was mutated in 6 oligodendrogliomas and FUBP1 gene was mutated in 2; 27 additional oligodendrogliomas showed 12 and 3 more tumors with mutations of CIC and FUBP1; results suggest role of these genes in biology and pathology of oligodendrocytes
ATP induces conformational changes in the carboxyl-terminal region of ClC-5.
Bear et al., Toronto, Canada. In J Biol Chem, 2011
ATP induces conformational changes in the carboxyl-terminal region of ClC-5.
The mitochondrial citrate carrier: metabolic role and regulation of its activity and expression.
Siculella et al., Lecce, Italy. In Iubmb Life, 2009
The citrate carrier (CiC), a nuclear-encoded protein located in the mitochondrial inner membrane, is a member of the mitochondrial carrier family.
Historia magistra vitae (Cic. De or. 2.36). The Prime Objective of Radiosurgery in Acoustic Neurinomas.
Strigari et al., Roma, Italy. In Neuroradiol J, 2006
The central question of stereotaxic radiosurgery in acoustic neurinomas is how to pinpoint its main objective: is it a better alternative to neurosurgery or an option when surgery is unfeasible?
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