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Baculoviral IAP repeat containing 3

cIAP2, cIAP1, API2
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: XIAP, PrP, bcl-2, CAN, NF-kappaB
Papers using cIAP2 antibodies
Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis.
Mayer Claudine, In PLoS ONE, 2009
... Antibodies against survivin, c-IAP1, and c-IAP2 were from Santa Cruz Biotechnology, Inc ...
The IKK2/NF-{kappa}B pathway suppresses MYC-induced lymphomagenesis
Siegmund D et al., In Cell Death & Disease, 2008
... and MS-581-P) was from Neomarkers (Fremont, CA, USA), anti-p100 (05-361) from Millipore (Temecula, CA, USA), anti-cIAP2 (51-9000062) was from BD (Heidelberg, Germany), and anti-NIK (4994), anti-rabbitHRP (7074) and anti-pIκBα (S32, 2859L) were from Cell Signaling Technologies (Danvers, MA, USA) ...
Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins
Streuli Charles H et al., In Breast Cancer Research : BCR, 2007
... The following primary antibodies were used: cIAP2 and Desmoplakin (Abcam, Cambridge, UK); monoclonal XIAP ...
Derivation of embryonic stem cell lines.
Green Douglas R., In PLoS Biology, 1992
... Myc-tagged murine c-IAP1 was obtained by subcloning into pCMV-Tag5 (Clontech).
Papers on cIAP2
MiR-145 promotes TNF-α-induced apoptosis by facilitating the formation of RIP1-FADDcaspase-8 complex in triple-negative breast cancer.
Xie et al., Wenzhou, China. In Tumour Biol, Feb 2016
The cellular inhibitor of apoptosis (cIAP1), which is the inhibitor of apoptosis protein, was found to be a target of miR-145 in MDA-MB-231 cells.
Expression of microRNA-452 via adenoviral vector inhibits non-small cell lung cancer cells proliferation and metastasis.
Jiang et al., Shenyang, China. In Tumour Biol, Jan 2016
Our data also shows that miR-452 down-regulates the expression of Bmi-1 as well as pro-survival or anti-apoptosis regulators Survivin, cIAP-1, and cIAP-2.
Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells.
Lau et al., Shantou, China. In Oncotarget, Jan 2016
Moreover, there was an induction of proapoptotic protein BAX, release of cytochrome c (CYCS) from mitochondria, activation of caspase-3/9 (CASP3/9); as well as decreased expression of cell cycle checkpoint proteins (TP53, p21, and p27) and several inhibitors of apoptosis proteins (IAPs) [including cIAP-1/2 (BIRC2/3), XIAP (BIRC4), and survivin (BIRC5)].
Regulation of antiapoptotic and cytoprotective pathways in colonic epithelial cells in ulcerative colitis.
Seidelin, Copenhagen, Denmark. In Scand J Gastroenterol, Dec 2015
The main results are that Fas mediated apoptosis is inhibited during flares of ulcerative colitis, probably by an upregulation of cellular inhibitor of apoptosis protein 2 (cIAP2) and cellular FLICE-like inhibitory protein.
Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: A review.
Shimosegawa et al., Sendai, Japan. In World J Gastroenterol, Aug 2015
Among these alterations, t(11;18)(q21;q21) is more frequently observed in H. pylori-negative gastric MALT lymphomas, and such translocation results in the synthesis of fusion protein API2-MALT1, which causes canonical and noncanonical NF-κB activation.
Targeting signaling factors for degradation, an emerging mechanism for TRAF functions.
Sun et al., Shanghai, China. In Immunol Rev, Jul 2015
TRAF2 and TRAF3 form a complex with the E3 ubiquitin ligase cIAP (cIAP1 or cIAP2), in which TRAF3 serves as the NIK-binding adapter.
FL118, a novel camptothecin analogue, overcomes irinotecan and topotecan resistance in human tumor xenograft models.
Li et al., Buffalo, United States. In Am J Transl Res, 2014
Consistent with our previous studies on irinotecan, FL118 exhibited ≥25 fold more effectiveness than topotecan at inhibiting cancer cell growth and colony formation; we further showed that although topotecan can inhibit the expression of survivin, Mcl-1, XIAP or cIAP2, its effectiveness is about 10-100 fold weaker than FL118.
Combinatorial cancer immunotherapy strategies with proapoptotic small-molecule IAP antagonists.
Lacasse et al., Ottawa, Canada. In Int J Dev Biol, 2014
Small molecule antagonists that target specific IAP oncoproteins, primarily cIAP1 and cIAP2, but potentially also XIAP and Livin, modulate distinct immune signal transduction pathways that can lead to an increased sensitivity of tumors cells to cytokine-mediated apoptosis.
Ginger and its constituents: role in prevention and treatment of gastrointestinal cancer.
Tyagi et al., Houston, United States. In Gastroenterol Res Pract, 2014
The anticancer activity of ginger is attributed to its ability to modulate several signaling molecules like NF-κB, STAT3, MAPK, PI3K, ERK1/2, Akt, TNF-α, COX-2, cyclin D1, cdk, MMP-9, survivin, cIAP-1, XIAP, Bcl-2, caspases, and other cell growth regulatory proteins.
Tubeimoside-1 (TBMS1) inhibits lung cancer cell growth and induces cells apoptosis through activation of MAPK-JNK pathway.
Zhou et al., Tianjin, China. In Int J Clin Exp Pathol, 2014
Furthermore, results from Western blotting and real-time PCR indicated that decreased the cell proliferation and cell growth-associated protein levels, such as p21, p15 and cyclin B1, TBMS1 up-regulated proapoptotic bax and cleavage of procaspase-3, down-regulated antiapoptotic Mcl-1 and cIAP-1, but did not change expression of PARP and procaspase-8.
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.
Kordula et al., Richmond, United States. In Nat Immunol, 2014
Newly synthesized IRF1 acquired Lys63 (K63)-linked polyubiquitination mediated by the apoptosis inhibitor cIAP2 that was enhanced by the bioactive lipid S1P.
BIRC2 amplification in squamous cell carcinomas of the uterine cervix.
Simon et al., Hamburg, Germany. In Virchows Arch, 2012
BIRC2 is amplified in a subset of squamous cell carcinoma of the uterine cervix.
Src, Akt, NF-κB, BCL-2 and c-IAP1 may be involved in an anti-apoptotic effect in patients with BCR-ABL positive and BCR-ABL negative acute lymphoblastic leukemia.
Lezama et al., Mexico. In Leuk Res, 2012
Src, Akt, NF-kappaB, BCL-2 and c-IAP1 may be involved in an anti-apoptotic effect in patients with BCR-ABL positive and BCR-ABL negative acute lymphoblastic leukemia.
Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis.
Kumar et al., Ottawa, Canada. In J Biol Chem, 2012
resistance to Vpr-induced apoptosis is specifically mediated by cIAP1/2 genes independent of Bcl-xL and Mcl-1, which play a key role in maintaining cell viability.
An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1.
Duckett et al., Ann Arbor, United States. In Biochem J, 2012
found that, despite extensive backcrossing into a C57BL/6 background, c-IAP1(-/-) animals are also deficient in caspase 11
Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.
Vucic et al., San Francisco, United States. In Sci Signal, 2012
c-IAP1 and c-IAP2 were required for canonical activation of NF-B and MAPK by members of the TNFR family.
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.
Tschopp et al., Lausanne, Switzerland. In Immunity, 2012
To determine whether IL-1β activation is regulated by inhibitor of apoptosis (IAP) proteins, we treated macrophages with an IAP-antagonist "Smac mimetic" compound or genetically deleted the genes that encode the three IAP family members cIAP1, cIAP2, and XIAP.
Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome.
Saleh et al., Montréal, Canada. In Immunity, 2012
Deficiency in cIAP1 (encoded by Birc2) or cIAP2 (Birc3) impaired caspase-1 activation after spontaneous or agonist-induced inflammasome assembly.
Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
Fairbrother et al., San Francisco, United States. In Science, 2011
Here biochemical and structural studies reveal that the unliganded, multidomain cIAP1 sequesters the RING domain within a compact, monomeric structure that prevents RING dimerization.
Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation.
McAllister-Lucas et al., Ann Arbor, United States. In Science, 2011
study shows API2-MALT1 fusion oncoprotein induces proteolytic cleavage of NF-kappaB-inducing kinase (NIK); resulting deregulated NIK activity is associated with constitutive noncanonical NF-kappaB signaling, enhanced B cell adhesion and apoptosis resistance
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