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Chymase 1, mast cell

chymase, mast cell protease
This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MAST, tryptase, Angiotensin II, CAN, IgE
Papers on chymase
Janicki et al., Columbia, United States. In Ijc Metab Endocr, Apr 2016
BACKGROUND: Cardiac mast cell (MC) proteases, chymase and tryptase, increase proliferation and collagen synthesis in cultured cardiac fibroblasts.
Revisiting the role of the mast cell in asthma.
Bjermer et al., Lund, Sweden. In Curr Opin Pulm Med, Jan 2016
RECENT FINDINGS: The heterogeneity of human mast cells has been recognized: MCTC expressing both tryptase and chymase and MCT expressing tryptase only.
Phenotypic variability in human skin mast cells.
Zuberbier et al., Berlin, Germany. In Exp Dermatol, Jan 2016
Pathophysiologically relevant key features were quantified and correlated: transcripts of c-kit, FcεRIα, FcεRIβ, FcεRIγ, histidine decarboxylase, tryptase, and chymase; surface expression of c-Kit, FcεRIα; activity of tryptase, and chymase; histamine content and release triggered by FcεRI and Ca(2+) ionophore.
Mast cell chymase in experimentally induced psoriasis.
Harvima et al., Kuopio, Finland. In J Dermatol, Jan 2016
UNASSIGNED: Mast cell chymase can have a pro-inflammatory or an immunosuppressive function in psoriasis, but the outcome may depend on the level of chymase activity.
Sputum mast cell subtypes relate to eosinophilia and corticosteroid response in asthma.
Gibson et al., Newcastle, Australia. In Eur Respir J, Jan 2016
Sputum mast cell subtypes were determined by molecular phenotyping based on expression of mast cell biomarkers (tryptase (TPSAB1), chymase (CMA1) and carboxypeptidase A3 (CPA3)).
Increased asthma and adipose tissue inflammatory gene expression with obesity and Inuit migration to a western country.
Gibson et al., Copenhagen, Denmark. In Respir Med, Jan 2016
Adipose tissue biopsies were homogenised, RNA extracted, and PCR was performed to determine the relative gene expression of mast cell (tryptase, chymase, CPA3) and inflammatory markers (IL-6, IL-1β, and CD163).
Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Disease.
Khalil et al., Boston, United States. In J Pharmacol Exp Ther, Dec 2015
Increased lower-extremity hydrostatic venous pressure is thought to induce hypoxia-inducible factors and other MMP inducers/activators such as extracellular matrix metalloproteinase inducer, prostanoids, chymase, and hormones, leading to increased MMP expression/activity, ECM degradation, VSM relaxation, and venous dilation.
Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy.
Wang et al., Cincinnati, United States. In Immunity, Nov 2015
Herein, we have reported the identification of multifunctional IL-9-producing mucosal mast cells (MMC9s) that can secrete prodigious amounts of IL-9 and IL-13 in response to IL-33, and mast cell protease-1 (MCPt-1) in response to antigen and IgE complex crosslinking, respectively.
Emerging small-molecule compounds for treatment of atopic dermatitis: a review.
Vávrová, Hradec Králové, Czech Republic. In Expert Opin Ther Pat, Nov 2015
These substances include compounds targeting the skin barrier (filaggrin production promoters, filaggrin breakdown products and compounds improving stratum corneum lipid barrier including pseudoceramides), anti-inflammatory compounds (PDE4/7 inhibitors, CRTH2 inhibitors, chemokine receptor antagonists, inhibitors of chymase and other) and compounds specifically targeting itch (TRP agonists, opioid ligands, serotonin 7 and histamine 4 antagonists).
The mast cell as a pluripotent HDL-modifying effector in atherogenesis: from in vitro to in vivo significance.
Kovanen et al., Helsinki, Finland. In Curr Opin Lipidol, Oct 2015
Upon activation, mast cells degranulate and expel 2 major neutral proteases, chymase and tryptase, and the vasoactive compound histamine, all of which are bound to the heparin-proteoglycan matrix of the granules.
Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data.
Djukanović et al., Geretsried, Germany. In Lancet, Mar 2015
BNA and TDA identified six novel clinicopathobiological clusters of underlying disease mechanisms, with elevated mast cell mediators tryptase (p<0·0001), chymase (p=0·02), and carboxypeptidase A3 (p=0·02) in severe asthma.
The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis.
Jamur et al., Ribeirão Preto, Brazil. In Biomed Res Int, 2014
The major constituents of mast cell secretory granules are the mast cell specific proteases chymase, tryptase, and carboxypeptidase A3.
Role of chymase in diabetic nephropathy.
Boim et al., São Paulo, Brazil. In Exp Biol Med (maywood), 2012
The results indicate an important role for chymase in inducing fibrosis through TGF-beta1 activation, parallel with Ang II effects.
TGF-β type II receptor/MCP-5 axis: at the crossroad between joint and growth plate development.
Spagnoli et al., Chapel Hill, United States. In Dev Cell, 2012
The transforming growth factor (TGF)beta type II receptor/MCP-5 axis is an essential crossroad for joint development and endochondral growth.
Association of mast cell-derived VEGF and proteases in Dengue shock syndrome.
Watanabe et al., Tokyo, Japan. In Plos Negl Trop Dis, 2011
As mast cells are an important source of VEGF, tryptase, and chymase, these findings suggest that mast cell activation and mast cell-derived mediators participate in the development of Dengue hemorrhagic fever.
Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue.
Ferrario et al., Winston-Salem, United States. In Plos One, 2010
a dominant role of cardiac chymase in the formation of Ang II from Ang-(1-12)
Immunoglobulin E and mast cell proteases are potential risk factors of human pre-diabetes and diabetes mellitus.
Shi et al., Huzhou, China. In Plos One, 2010
Both IgE and chymase associate with diabetes status.
The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease.
Nishiyama et al., New Orleans, United States. In Pharmacol Rev, 2007
In addition to the classic RAS pathways, prorenin receptors and chymase are also involved in local Ang II formation in the kidney.
IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities.
Bulfone-Paus et al., Germany. In Nat Med, 2007
By showing that intracellular IL-15 acts as a specific negative transcriptional regulator of a mouse MC chymase (mast cell protease-2), we provide evidence that defined MC protease activity is transcriptionally regulated by an intracellularly retained cytokine.
Association between genetic variants of mast-cell chymase and eczema.
Morimoto et al., Suita, Japan. In Lancet, 1996
IgE and mast-cell chymase (MCC-a serine protease secreted by skin mast cells) have a key role in atopic or allergic inflammation of the skin.
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