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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Visual system homeobox 2

Chx10, Vsx2, RET1
This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CAN, Pax6, Sox2, POLYMERASE, Otx2
Papers using Chx10 antibodies
Cell-autonomous action of zebrafish spt-1 mutation in specific mesodermal precursors
Harris William A et al., In Neural Development, 1989
... vsx2, and a transgenic line expressing GFP under ...
Papers on Chx10
Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications.
Thomas et al., Singapore, Singapore. In Rna Biol, Feb 2016
Using the Trypanosoma brucei TUTase, RET1, we identify TUTase inhibitors and lay the groundwork for the use of this new target class as a therapeutic opportunity for the under-served disease area of African Trypanosomiasis.
Neuronal labeling patterns in the spinal cord of adult transgenic Zebrafish.
Drapeau et al., Montréal, Canada. In Dev Neurobiol, Oct 2015
We used well-known transgenic lines in which expression of green fluorescent protein (GFP) is driven by promoters to hb9 and isl1 in motoneurons, alx/chx10 and evx1 interneurons, ngn1 in sensory neurons and olig2 in oligodendrocytes, as well as antibodies for neurons (HuC/D, NF and SV2) and glia (GFAP).
Transcription factor PRDM8 is required for rod bipolar and type 2 OFF-cone bipolar cell survival and amacrine subtype identity.
McInnes et al., Bristol, United Kingdom. In Proc Natl Acad Sci U S A, Jul 2015
To determine whether Prdm8 is essential to BP cell development or physiology, we targeted the gene in mice.
Analysis of opo cis-regulatory landscape uncovers Vsx2 requirement in early eye morphogenesis.
Martinez-Morales et al., Sevilla, Spain. In Nat Commun, 2014
Among the different conserved enhancers identified, we isolate a single retina-specific element (H6_10137) and show that its activity depends on binding sites for the retinal determinant Vsx2.
Genetic Evidence for the Role of the Vacuole in Supplying Secretory Organelles with Ca2+ in Hansenula polymorpha.
Agaphonov et al., Moscow, Russia. In Plos One, 2014
Here we observed that in the yeast Hansenula polymorpha Ca2+ deficiency in the secretory pathway caused by Pmr1 inactivation is exacerbated by (i) the ret1-27 mutation affecting COPI-mediated vesicular transport, (ii) inactivation of the vacuolar Ca2+ ATPase Pmc1 and (iii) inactivation of Vps35, which is a component of the retromer complex responsible for protein transport between the vacuole and secretory organelles.
VSX2 and ASCL1 Are Indicators of Neurogenic Competence in Human Retinal Progenitor Cultures.
Gamm et al., Madison, United States. In Plos One, 2014
Visual System Homeobox 2 (VSX2) labels all multipotent retinal progenitor cells (RPCs) and is known to play important roles in retinal development.
The genetic architecture of microphthalmia, anophthalmia and coloboma.
FitzPatrick et al., Edinburgh, United Kingdom. In Eur J Med Genet, 2014
In severe bilateral cases (anophthalmia or severe microphthalmia) the genetic cause is now identifiable in approximately 80 percent of cases, with de novo heterozygous loss-of-function mutations in SOX2 or OTX2 being the most common.
Mitochondrial RNA editing in trypanosomes: small RNAs in control.
Aphasizheva et al., Boston, United States. In Biochimie, 2014
Mitochondrial mRNA editing in trypanosomes is a posttranscriptional processing pathway thereby uridine residues (Us) are inserted into, or deleted from, messenger RNA precursors.
Regulatory role for a conserved motif adjacent to the homeodomain of Hox10 proteins.
Mallo et al., Portugal. In Development, 2012
analysis of the regulatory role of a conserved motif adjacent to the homeodomain of Hox10 proteins
Restoration of retinal development in Vsx2 deficient mice by reduction of Gdf11 levels.
Calof et al., Irvine, United States. In Adv Exp Med Biol, 2011
Reducing GDF11 levels might promote restoration of retinal development in the microophthalmic Vsx2 mutant mouse.
Eye development genes and known syndromes.
Slavotinek, San Francisco, United States. In Mol Genet Metab, 2011
In addition, we briefly discuss the ocular and extraocular phenotypes associated with several other important eye developmental genes, including GDF6, VSX2, RAX, SHH, SIX6 and PAX6.
Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy.
Matsumoto et al., Yokohama, Japan. In Am J Hum Genet, 2011
Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy
Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy.
Bernard et al., Montréal, Canada. In Am J Hum Genet, 2011
Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy
Uridine insertion/deletion editing in trypanosomes: a playground for RNA-guided information transfer.
Aphasizheva et al., Irvine, United States. In Wiley Interdiscip Rev Rna, 2011
RNA editing is a collective term referring to enzymatic processes that change RNA sequence apart from splicing, 5' capping or 3' extension.
VSX2 mutations in autosomal recessive microphthalmia.
Semina et al., Milwaukee, United States. In Mol Vis, 2010
Mutations in VSX2 represent an important cause of autosomal recessive microphthalmia in consanguineous pedigrees.
Anophthalmia and microphthalmia.
Fitzpatrick et al., Edinburgh, United Kingdom. In Orphanet J Rare Dis, 2006
Both anophthalmia and microphthalmia may occur in isolation or as part of a syndrome, as in one-third of cases.
Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord.
Goldman et al., New York City, United States. In Nat Biotechnol, 2004
The hTERT-immortalized cells divided in basic fibroblast growth factor (bFGF) expressed high telomerase activity, and gave rise to phenotypically restricted subpopulations of either glia or neurons.
Human microphthalmia associated with mutations in the retinal homeobox gene CHX10.
McInnes et al., Farmington, United States. In Nat Genet, 2000
We previously found that mice with ocular retardation (the or-J allele), a microphthalmia phenotype, have a null mutation in the retinal homeobox gene Chx10 (refs 7,8).
Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation.
McInnes et al., Ann Arbor, United States. In Nat Genet, 1996
Ocular retardation (or) is a murine eye mutation causing microphthalmia, a thin hypocellular retina and optic nerve aplasia.
Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum.
Cosson et al., Basel, Switzerland. In Cell, 1995
Whereas retrieval was unaffected in most sec mutants tested (sec7, sec12, sec13, sec16, sec17, sec18, sec19, sec22, and sec23), a defect in retrieval was observed in previously characterized coatomer mutants (sec21-1, sec27-1), as well as in newly isolated retrieval mutants (sec21-2, ret1-1).
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