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DNA-damage-inducible transcript 3

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: GRP78, PrP, EBP, V1a, CAN
Papers using CHOP antibodies
Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction
Wu Yu-Jen et al., In Marine Drugs, 2011
... calreticulin(CALR), protein disulfide isomerase (PDI), Bax, Bcl-xL and Bcl-2, PERK, phospho-PERK (p-PERK), phospho-elF2α (p-elF2α) and CHOP were from Cell Signaling Technology (Danvers, MA, USA) ...
Thematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity
Bar-Tana Jacob et al., In Diabetes, 2007
... Anti- STAT3, FoxO1, P-FoxO1(T24)/P-FoxO3a(T32), rabbit C/EBPβ/LAP, and CHOP antibodies were from Cell Signaling Technology ...
High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice.
Ferreira Sergio T., In PLoS ONE, 2007
... siRNA to gadd153/CHOP and non silencing control siRNA were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Novel role of protein disulfide isomerase in the regulation of NADPH oxidase activity: pathophysiological implications in vascular diseases.
Kowaltowski Alicia J., In PLoS ONE, 2007
... Antibodies were obtained as follows: PDI and KDEL from Assay Designs/Stressgen (Ann Arbor, MI); CHOP/GADD153 from Thermo Scientific (Golden, CO); Akt, phospho-Akt, ...
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells
Rozenfeld R et al., In Cell Death & Disease, 2007
... , anti-phospho-PERK, mouse monoclonal anti-CHOP (Cell Signaling Technology, Danvers, MA, USA), ...
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Papers on CHOP
c-Jun N-terminal Kinase-Dependent Endoplasmic Reticulum Stress Pathway is Critically Involved in Arjunic Acid Induced Apoptosis in Non-Small Cell Lung Cancer Cells.
Kim et al., Suwŏn, South Korea. In Phytother Res, Feb 2016
Furthermore, arjunic acid upregulated the expression of endoplasmic reticulum (ER) stress proteins such as IRE1 α, ATF4, p-eIF2α, and C/EBP homologous protein (CHOP) in A549 and H460 cells.
Sulforaphane prevents rat cardiomyocytes from hypoxia/reoxygenation injury in vitro via activating SIRT1 and subsequently inhibiting ER stress.
Chen et al., Guangzhou, China. In Acta Pharmacol Sin, Feb 2016
Meanwhile, SFN significantly alleviated the damage of ΔΨm and decreased the expression of ER stress-related apoptosis proteins (GRP78, CHOP and caspase-12), elevating the expression of SIRT1 and Bcl-2/Bax ratio in the cardiomyocytes.
Traditional Chinese medicine targeting apoptotic mechanisms for esophageal cancer therapy.
Li et al., Shijiazhuang, China. In Acta Pharmacol Sin, Jan 2016
By using different monomers and composite prescriptions of TCM, it is possible to modulate the ratio of Bcl-2/Bax, regulate the expression of caspase proteases and mitochondrial transmembrane potential, increase the expression of Fas and p53, down-regulate NF-κB pathway and the expression of CHOP and survivin, and block cell cycle progression.
Novel targeted therapeutics for mantle cell lymphoma - What's on the horizon?
Ribrag et al., Villejuif, France. In Expert Rev Hematol, Jan 2016
Incorporation of rituximab to CHOP regimen, the adoption of high dose cytarabine with frontline autologous stem cell transplantation in young patients, maintenance rituximab or bortezomib based chemotherapy in elderly patients, improved the disease outcome.
Using the pathology report in initial treatment decisions for diffuse large B-cell lymphoma: time for a precision medicine approach.
Friedberg, Rochester, United States. In Hematology Am Soc Hematol Educ Program, Jan 2016
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non Hodgkin lymphoma in the Western world, and is potentially curable with standard R-CHOP chemoimmunotherapy.
IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation.
Qi et al., Ithaca, United States. In Nat Cell Biol, Dec 2015
Although enterocyte-specific Sel1L-knockout mice (Sel1L(ΔIEC)) are viable and seem normal, they are highly susceptible to experimental colitis and inflammation-associated dysbiosis, in an IRE1α-dependent but CHOP-independent manner.
Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis.
Sun et al., Guangzhou, China. In Plos One, Dec 2015
Furthermore, sodium butyrate treatment markedly enhanced the expression of endoplasmic reticulum stress-associated proteins, including BIP, CHOP, PDI, and IRE-1a.
Interleukin-22 Alleviated Palmitate-Induced Endoplasmic Reticulum Stress in INS-1 Cells through Activation of Autophagy.
Zhang et al., Guangzhou, China. In Plos One, Dec 2015
The protein expression of glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), microtubule-associated protein light chain 3B (LC3B) and Bcl-2-interacting myosin-like coiled-coil protein (Beclin-1) were evaluated by western blot.
BMP-1 participates in the selection and dominance of buffalo follicles by regulating the proliferation and apoptosis of granulosa cells.
Shi et al., Nanning, China. In Theriogenology, Dec 2015
Adding BMP1 recombinant protein to the culture medium of the GCs increased the expression of the key cell cycle regulators such as cyclin D1 and cyclin D2 and downregulated the expression of cell apoptosis pathway genes such as Cytochrome C, Fas, FasL, and Chop, both at the mRNA and at the protein levels.
Prognostic Significance of Diffuse Large B-Cell Lymphoma Cell of Origin Determined by Digital Gene Expression in Formalin-Fixed Paraffin-Embedded Tissue Biopsies.
Gascoyne et al., Vancouver, Canada. In J Clin Oncol, Oct 2015
The assay was then applied to pretreatment formalin-fixed paraffin-embedded tissue (FFPET) biopsies from 344 patients with de novo diffuse large B-cell lymphoma (DLBCL) uniformly treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) at the British Columbia Cancer Agency.
Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry.
Weigert et al., München, Germany. In Lancet Oncol, Sep 2015
METHODS: We did DNA deep sequencing to retrospectively analyse the mutation status of 74 genes in 151 follicular lymphoma biopsy specimens that were obtained from patients within 1 year before beginning immunochemotherapy consisting of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP).
Diffuse large B-cell lymphoma classification system that associates normal B-cell subset phenotypes with prognosis.
Johnsen et al., Odense, Denmark. In J Clin Oncol, May 2015
The impact of BAGS-assigned subtyping was analyzed using five clinical cohorts (treated with cyclophosphamide, doxorubicin, vincristine, and prednisone [CHOP], n = 270; treated with rituximab plus CHOP [R-CHOP], n = 869) gathered across geographic regions, time eras, and sampling methods.
Bortezomib-based therapy for newly diagnosed mantle-cell lymphoma.
LYM-3002 Investigators et al., Aş Şanamayn, Syria. In N Engl J Med, Apr 2015
We investigated whether substituting bortezomib for vincristine in frontline therapy with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) could improve outcomes in patients with newly diagnosed mantle-cell lymphoma.
Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review.
Hassa et al., Zürich, Switzerland. In Mol Cancer, 2014
More than half of DLBLC patients can be cured with standard R-CHOP regimens, however approximately 30 to 40 % of patients will develop relapsed/refractory disease that remains a major cause of morbidity and mortality due to the limited therapeutic options.Recent advances in gene expression profiling have led to the identification of at least three distinct molecular subtypes of DLBCL: a germinal center B cell-like subtype, an activated B cell-like subtype, and a primary mediastinal B-cell lymphoma subtype.
Non-Hodgkin lymphoma diagnosed by a percutaneous trans-hepatic needle biopsy of portal vein tumor emboli.
Takahashi et al., In Rinsho Ketsueki, 2014
A complete response was achieved after six courses of R-CHOP and it was confirmed by splenectomy.
ERK1/2-dependent bestrophin-3 expression prevents ER-stress-induced cell death in renal epithelial cells by reducing CHOP.
Thévenod et al., Witten, Germany. In Biochim Biophys Acta, 2012
ERK1/2-dependent Best-3 activation regulates cell fate decisions during endoplasmic reticulum stress by suppressing CHOP induction and death.
Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells.
Ko et al., T'ai-chung-shih, Taiwan. In Toxicol Appl Pharmacol, 2012
lipocalin 2 is a new GADD153 target gene that mediates endoplasmic reticulum stress-induced apoptosis in lung cancer cells
Reactive oxygen species-triggered trophoblast apoptosis is initiated by endoplasmic reticulum stress via activation of caspase-12, CHOP, and the JNK pathway in Toxoplasma gondii infection in mice.
Shen et al., Hefei, China. In Infect Immun, 2012
It was concluded that apoptosis in placental trophoblasts was initiated predominantly by ROS-mediated ERS via activation of caspase-12, CHOP, and the JNK pathway in acute T. gondii infection.
Endoplasmic reticulum stress in retinal vascular degeneration: protective role of resveratrol.
Zheng et al., Wuhan, China. In Invest Ophthalmol Vis Sci, 2012
High dosage of resveratrol pretreatment inhibited the injury-induced up-regulation of eIF2alpha-CHOP and IRE1alpha-XBP1 pathways.
Free cysteine modulates the conformation of human C/EBP homologous protein.
Jia et al., Kingston, Canada. In Plos One, 2011
These results suggested a potential regulatory function of L-cysteine which may lead to changes in global conformation of CHOP in response to the cellular redox state and/or endoplasmic reticulum stress.
More papers using CHOP antibodies
Neuronal conduction of excitation without action potentials based on ceramide production
Hoheisel Jörg D., In PLoS ONE, 2006
... immunoglobulins (IgG), antibodies to PTEN, to (Ser380)phospho-PTEN, to GSK-3β, to (Ser9)phospho GSK-3β, and antibodies to CHOP were from Cell Signaling (Beverly, MA) ...
Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta-cells
Sun Zilin et al., In International Journal of Molecular Sciences, 2004
... anti-GAPDH, phosphor-eIF2α, eIF2α, caspase 3 and insulin antibodies were purchased from Cell signaling technology, rabbit anti-CHOP (GADD153) antibody were from Santa Cruz Biotechnology.
Hepatitis C virus non-structural proteins in the probable membranous compartment function in viral genome replication.
Jhaveri Ravi, In PLoS ONE, 2002
... (p-PERK), and CHOP were purchased from Cell Signaling Technology (Beverly, USA) ...
Protection of retinal epithelial cells against oxidative injury by endoplasmic reticulum stress preconditioning is mediated by ERK1/2 activation
Wu Jang-Yen et al., In Journal of Biomedical Science, 2002
... Mouse anti-actin, rabbit anti-Bax, rabbit anti–Bcl-2, rabbit anti-GRP78, rabbit anti-CHOP/GADD153 antibodies, and secondary mouse and rabbit antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity
Murakami Koji et al., In Journal of Lipid Research, 2001
... Antibodies against PERK, eIF2, phospho-eIF2, and CHOP were purchased from Cell Signaling Technology (Beverly, MA) ...
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor
Tabas Ira et al., In The Journal of Cell Biology, 1997
... The mouse monoclonal antibodies against GADD 153 (CHOP) and tubulin were purchased from Santa Cruz Biotechnology, Inc ...
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
Ron David et al., In The Journal of Cell Biology, 1997
... CHOP coding region, to enhanced green fluorescent protein (GFP) (CLONTECH Laboratories, Inc.) and termination ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
Pereira T S et al., In Cell Death & Disease, 1994
... cleaved forms; 1:200, IMG-273, IMGENEX, San Diego, CA, USA), anti-Bip (1:500, #3177, Cell Signaling Technology), anti-CHOP (1:200, sc-575, Santa Cruz Biotechnology), anti- ...
Castanospermine inhibits alpha-glucosidase activities and alters glycogen distribution in animals.
Chammas Roger, In PLoS ONE, 1984
... western blotting, anti-KDEL for GRP78 and GRP94 was purchased from Stressgen, (Ann Arbor, MI), polyclonal anti-CHOP/GADD153 was purchased from Santa Cruz Biotechnology (Santa Cruz, CA), and ...
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