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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cholesterol 25-hydroxylase

cholesterol 25-hydroxylase
Top mentioned proteins: V1a, apolipoprotein E, CAN, CTX, EBI2
Papers on cholesterol 25-hydroxylase
Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.
Steinmann et al., Hannover, Germany. In Hepatology, Sep 2015
Recent studies have reported that cholesterol 25-hydroxylase (CH25H) is expressed as an interferon-stimulated gene and mediates antiviral activities against different enveloped viruses through the production of 25-hydroxycholesterol (25HC).
Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection.
Zhong et al., Shanghai, China. In J Virol, Jul 2015
In this study, we showed that 25HC and its synthesizing enzyme cholesterol 25-hydroxylase (CH25H) efficiently inhibit HCV infection at a postentry stage.
Five-aza-2'-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells.
Tohyama et al., Okayama, Japan. In Sci Rep, 2014
Hence, we performed a genome-wide DNA methylation assay and focused on cholesterol 25-hydroxylase (CH25H) among the genes whose expression was up-regulated and whose promoter region was hypomethylated after decitabine (DAC) treatment in vitro.
Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon.
Cyster et al., San Francisco, United States. In Science, 2014
Here, we report that activated mouse macrophages lacking the IFN-stimulated gene cholesterol 25-hydroxylase (Ch25h) and that are unable to produce the oxysterol 25-hydroxycholesterol (25-HC) overproduce inflammatory interleukin-1 (IL-1) family cytokines.
Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages.
Sailer et al., Basel, Switzerland. In Biochem Biophys Res Commun, 2014
First, we show that primary human macrophages express EBI2 and the enzymes needed for ligand production such as cholesterol 25-hydroxylase (CH25H), sterol 27-hydroxylase (CYP27A1), and oxysterol 7α-hydroxylase (CYP7B1).
Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature.
Kotelevtsev et al., Moscow, Russia. In Bmc Geriatr, 2013
MECHANISM: Infection and inflammation selectively induce the expression of cholesterol 25-hydroxylase (CH25H).
On the role of 25-hydroxycholesterol synthesis by glioblastoma cell lines. Implications for chemotactic monocyte recruitment.
Sattler et al., Graz, Austria. In Exp Cell Res, 2013
Here, we investigated expression and transcriptional regulation of cholesterol 25-hydroxylase (CH25H) in human U87MG and GM133 glioblastoma cell lines.
How are STAT1 and cholesterol metabolism associated in antiviral responses?
Imaizumi et al., Hirosaki, Japan. In Jakstat, 2013
STAT1 was shown to be the most essential transcriptional factor involved in the induction of cholesterol 25-hydroxylase (Ch25h), the enzyme required to produce 25HC, indicating the importance of STAT1 in oxysterol-mediated innate immunity.
On the formation and possible biological role of 25-hydroxycholesterol.
Diczfalusy, Huddinge, Sweden. In Biochimie, 2013
The dioxygenase enzyme cholesterol 25-hydroxylase has been shown to generate 25-hydroxycholesterol, but in cholesterol 25-hydroxylase knockout mice there are still significant levels of 25-hydroxycholesterol in several tissues.
25-Hydroxycholesterol regulates cholesterol homeostasis in the murine CATH.a neuronal cell line.
Sattler et al., Graz, Austria. In Neurosci Lett, 2013
A single i.p. injection of lipopolysaccharide resulted in robust induction of cholesterol 25-hydroxylase mRNA and protein levels in brains of treated mice.
Disruption of Rorα1 and cholesterol 25-hydroxylase expression attenuates phagocytosis in male Rorαsg/sg mice.
Muscat et al., Brisbane, Australia. In Endocrinology, 2013
Notably, we identified decreased expression of the mRNA encoding cholesterol 25-hydroxylase (Ch25h), an enzyme that converts cholesterol to 25-hydroxycholesterol (25HC), an oxysterol with emerging roles in immunity.
ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol-induced lipid body formation.
Aderem et al., Seattle, United States. In J Exp Med, 2012
Indeed, we found that deletion of this TF results in increased lipid body accumulation, and that ATF3 directly regulates transcription of the gene encoding cholesterol 25-hydroxylase.
Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease.
Ichinose et al., Wakayama, Japan. In Respirology, 2012
BACKGROUND AND OBJECTIVE: 25-Hydroxycholesterol (25-HC) is produced from cholesterol by the enzyme cholesterol 25-hydroxylase and is associated with atherosclerosis of vessels.
Genomics and proteomics of vertebrate cholesterol ester lipase (LIPA) and cholesterol 25-hydroxylase (CH25H).
Cox et al., In 3 Biotech, 2011
and cholesterol 25-hydroxylase (CH25H; EC play essential role in cholesterol metabolism in the body by hydrolysing cholesteryl esters and triglycerides within lysosomes (LIPA) and catalysing the formation of 25-hydroxycholesterol from cholesterol (CH25H) which acts to repress cholesterol biosynthesis.
Oxysterols direct immune cell migration via EBI2.
Sailer et al., Saudi Arabia. In Nature, 2011
A critical enzyme required for the generation of 7α,25-OHC is cholesterol 25-hydroxylase (CH25H).
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