Phosphatidylserine in the brain: metabolism and function.
Bethesda, United States. In Prog Lipid Res, 2014
PS is synthesized from phosphatidylcholine or phosphatidylethanolamine by exchanging the base head group with serine, and this reaction is catalyzed by phosphatidylserine synthase 1 and phosphatidylserine synthase 2 located in the endoplasmic reticulum.
Cytokinesis and cancer: Polo loves ROCK'n' Rho(A).
Beijing, China. In J Genet Genomics, 2010
More specifically, Plk1 phosphorylates the centralspindlin complex Cyk4 and MKLP1/CHO1, thus recruiting RhoA guanine nucleotide-exchange factor (GEF) Ect2 through its phosphopeptide-binding BRCT domains.
Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc depletion.
New Brunswick, United States. In Biochim Biophys Acta, 2007
Alterations in phosphatidylinositol and phosphatidylethanolamine can be ascribed to an increase in PIS1-encoded phosphatidylinositol synthase activity and to decreases in the activities of CDP-diacylglycerol pathway enzymes including the CHO1-encoded phosphatidylserine synthase, respectively.
Cell cycle regulation of central spindle assembly.
Vienna, Austria. In Nature, 2004
Central spindle assembly requires the centralspindlin complex composed of the Caenorhabditis elegans ZEN-4 (mammalian orthologue MKLP1) kinesin-like protein and the Rho family GAP CYK-4 (MgcRacGAP).