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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cathepsins, ACID, HAD, Calpain, CAN
Papers using CHN2 antibodies
Glycosaminoglycan-mediated loss of cathepsin K collagenolytic activity in MPS I contributes to osteoclast and growth plate abnormalities.
Jones Malcolm, In PLoS Neglected Tropical Diseases, 2008
... Z-Phe-Arg-NHMec, Z-Leu-Arg-NHMec, Z-Val-Val-Arg-NHMec, Tos-Gly-Pro-Arg-NMec, Tos-Gly-Pro-Lys-NMec, Boc-Ala-Gly-Pro-Arg-NMec, Boc-Val-Leu-Lys-NMec, Boc-Val-Pro-Arg-NMec, Z-Phe-Ala-CHN2, Z-Gly-Pro-Gly-Gly-Pro-Ala and Z-Gly-Pro-Leu-Gly-Pro were obtained from Bachem (St ...
Papers on CHN2
Silver(I)-Catalyzed N-Trifluoroethylation of Anilines and O-Trifluoroethylation of Amides with 2,2,2-Trifluorodiazoethane.
Wang et al., Beijing, China. In Angew Chem Int Ed Engl, Dec 2015
A straightforward N-trifluoroethylation of anilines has been developed based on silver-catalyzed NH insertions with 2,2,2-trifluorodiazoethane (CF3 CHN2 ).
Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility.
Salto-Tellez et al., Belfast, United Kingdom. In Oncotarget, Sep 2015
Merging gene expression and DNA methylation data revealed CHN2 as consistently hypermethylated and downregulated in this disease (Spearman -0.71, p < 0.001).
High-Resolution Array Comparative Genomic Hybridization Utility in Polish Newborns with Isolated Cleft Lip and Palate.
Bocian et al., Warsaw, Poland. In Neonatology, 2014
In addition, 2 novel candidate genes for cleft lip and palate, CHN2 and CDH19, are suggested.
Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.
Ling et al., Malmö, Sweden. In Bmc Med, 2014
RESULTS: We identified differential DNA methylation of 349 CpG sites representing 233 unique genes including TNF, CHI3L1 (also known as YKL-40), CHN2, GIPR, GLRA1, GPX1, AHRR, and BCOR in cases with PDR compared with controls.
Chimerin 2 genetic polymorphisms are associated with non-proliferative diabetic retinopathy in Taiwanese type 2 diabetic patients.
Tsai et al., Taipei, Taiwan. In J Diabetes Complications, 2014
AIM: To investigate whether chimerin 2 (CHN2) genetic polymorphisms were associated with the susceptibility to diabetic retinopathy (DR) in Taiwanese individuals with type 2 diabetes.
Genome characterization of sugarcane yellow leaf virus from China reveals a novel recombinant genotype.
Mirkov et al., Fuzhou, China. In Arch Virol, 2014
Among the nine known SCYLV genotypes existing worldwide, COL, HAW, REU, IND, CHN1, CHN2, BRA, CUB and PER, the last five have been reported in China.
Generation of C(2)F(5)CHN(2) in situ and its first reaction: [3+2] cycloaddition with alkenes.
Mykhailiuk, Ukraine. In Chemistry, 2014
The novel chemical reagent, C2 F5 CHN2 , is generated in situ from C2 F5 CH2 NH2 ⋅HCl and sodium nitrite.
Influence of model grid resolution on NO2 vertical column densities over East Asia.
Ohara et al., In J Air Waste Manag Assoc, 2014
The biases of the NO2 VCDs simulated at a resolution of 20 km against the satellite retrievals were -36% near Beijing (CHN1) and -78% near Shanghai (CHN2) in summer; these errors were found to be comparable to the horizontal resolution-dependent errors, which were 18-25% at CHN1 and 44-58% at CHN2 from 80 km to 40 km.
Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines.
Motsinger-Reif et al., Raleigh, United States. In Pharmacogenomics, 2014
Three of these, MED12L, CHN2 and MGMT, have been previously implicated in cancer pharmacogenomics.
β3-chimaerin, a novel member of the chimaerin Rac-GAP family.
Leskow et al., Buenos Aires, Argentina. In Mol Biol Rep, 2013
Four isoforms have been reported to-date, which are products of CHN1 (α1- and α2-chimaerins) and CHN2 (β1- and β2-chimaerins) genes.
Integrative genomic and transcriptomic analysis identified candidate genes implicated in the pathogenesis of hepatosplenic T-cell lymphoma.
Wlodarska et al., Leuven, Belgium. In Plos One, 2013
enhanced expression of CHN2/β2-chimerin leads to downmodulation of the NFAT pathway and a proliferative response, while upregulation of the CGR-related genes provides growth advantage for neoplastic δγT-cells and underlies their intrinsic chemoresistance.
Analysis of common and coding variants with cardiovascular disease in the Diabetes Heart Study.
Bowden et al., Winston-Salem, United States. In Cardiovasc Diabetol, 2013
From the exome chip, rs3750103 (CHN2, His204Arg/His68Arg) with carotid intima-medial thickness (IMT) (p = 3.9×10(-5)), and rs61937878 (HAL, Val549Met) with infra-renal abdominal aorta CP (AACP) (p = 7.1×10(-5)).
Evaluation of candidate nephropathy susceptibility genes in a genome-wide association study of African American diabetic kidney disease.
Bowden et al., Winston-Salem, United States. In Plos One, 2013
association at other loci was markedly reduced except for CHN2 (chimerin; rs17157914, P(emp)= 0.029).
The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus.
Kolodkin et al., Baltimore, United States. In Cell, 2012
Study demonstrates that Sema3F-dependent inhibition of Rac1 by the Rac-GAP beta2Chn is required for hippocampal infrapyramidal tract pruning.
CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients.
Jia et al., Shanghai, China. In Diabetes, 2011
genetic association studies in a Chinese population with type 2 diabetes: An SNP in CHN2 (rs39059) is associated with diabetic retinopathy in a Chinese population of type 2 diabetic patients.
A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation.
Kazanietz et al., Philadelphia, United States. In J Biol Chem, 2010
the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation
Severe insulin resistance and intrauterine growth deficiency associated with haploinsufficiency for INSR and CHN2: new insights into synergistic pathways involved in growth and metabolism.
Gloyn et al., Oxford, United Kingdom. In Diabetes, 2009
Likely digenic cause of insulin resistance and growth deficiency resulting from the combined heterozygous disruption of INSR and CHN2, implicating CHN2 for the first time as a key element of proximal insulin signaling in vivo.
Beta2-chimaerin binds to EphA receptors and regulates cell migration.
Katoh et al., Kyoto, Japan. In Febs Lett, 2009
results suggest that beta2-chimaerin is activated by EphA receptors and mediates the EphA receptor-dependent regulation of cell migration
Bacterial growth blocked by a synthetic peptide based on the structure of a human proteinase inhibitor.
Grubb et al., Lund, Sweden. In Nature, 1989
Several bacteria produce proteinases, so we tested a tripeptide derivative (Z-LVG-CHN2) for in vitro anti-bacterial activity against a large number of bacterial strains belonging to thirteen different species.
Protein degradation in cell cultures: general considerations on mechanisms and regulation.
Dean, In Fed Proc, 1980
This work has utilized a new group specific inhibitor of thiol proteinases, synthesized by Dr. Elliot Shaw, carbobenzoxycarbonyl-L-phenylalanyl-L-alanine-D-dizaomethane (Z-Phe-Ala-CHN2).
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