Long-term proliferation of human embryonic stem cell-derived neuroepithelial cells using defined adherent culture conditions.more suppliers
In PLoS ONE, 2005
... -β-actin (Santa Cruz Biotechnology), -Nestin, -γ-H2AX (clone JBW301), -GFAP, -Sox2, -Musashi-1 (Millipore), -RAD51 (EMD Biosciences), -pT68-CHK2 (Cell Signaling), and -ATR (2B5), and ...
Multigene testing of moderate-risk genes: be mindful of the missense.
Salt Lake City, United States. In J Med Genet, Feb 2016
METHODS: We evaluated rare missense substitutions identified from a mutation screen of ATM, CHEK2, MRE11A, RAD50, NBN, RAD51, RINT1, XRCC2 and BARD1 in 1297 cases of early-onset breast cancer and 1121 controls via scores from Align-Grantham Variation Grantham Deviation (GVGD), combined annotation dependent depletion (CADD), multivariate analysis of protein polymorphism (MAPP) and PolyPhen-2.
CHK2 stability is regulated by the E3 ubiquitin ligase SIAH2.
Córdoba, Spain. In Oncogene, Feb 2016
UNASSIGNED: The serine threonine checkpoint kinase 2 (CHK2) is a critical protein involved in the DNA damage-response pathway, which is activated by phosphorylation inducing cellular response such as DNA repair, cell-cycle regulation or apoptosis.
SOG1: a master regulator of the DNA damage response in plants.
Kyoto, Japan. In Genes Genet Syst, Feb 2016
Arabidopsis thaliana has orthologs of several DDR factors that are present in animals; however, some of the important animal regulators, such as the tumor suppressor p53 and the DDR kinases CHK1 and CHK2, have not been found in plants.
Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis.
Tel Aviv-Yafo, Israel. In Bmc Genomics, Dec 2015
CONCLUSIONS: Our findings provide the first high-resolution genome-wide view of chromosomal changes in hemangioblastoma and identify 23 candidate genes: EGFR, PRDM16, PTPN11, HOXD11, HOXD13, FLT3, PTCH, FGFR1, FOXP1, GPC3, HOXC13, HOXC11, MKL1, CHEK2, IRF4, GPHN, IKZF1, RB1, HOXA9, and micro RNA, such as hsa-mir-196a-2 for hemangioblastoma pathogenesis.
DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.
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Manchester, United Kingdom. In N Engl J Med, Nov 2015
Next-generation sequencing identified homozygous deletions, deleterious mutations, or both in DNA-repair genes--including BRCA1/2, ATM, Fanconi's anemia genes, and CHEK2--in 16 of 49 patients who could be evaluated (33%).