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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Checkpoint with forkhead and ring finger domains

Top mentioned proteins: Ubiquitin, CAN, POLYMERASE, HAD, p16
Papers using CHFR antibodies
Aberrant methylation of the CHFR gene is frequently detected in non-invasive colorectal cancer.
Abraham Edathara, In PLoS ONE, 2005
... Both the wild-type and mutant CHFR cDNA fragments were also subcloned into an LXIN retrovirus vector (Clontech), the pcDNA 3.1+ plasmid ...
Papers on CHFR
CHFR hypermethylation, a frequent event in acute myeloid leukemia, is independently associated with an adverse outcome.
Ma et al., Beijing, China. In Genes Chromosomes Cancer, Feb 2016
The CpG island of the promoter region of the checkpoint with fork-head associated and ring finger gene (CHFR), a mitotic checkpoint gene with tumor-suppressor functions, is hypermethylated in various human cancers.
High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing.
Sepulveda et al., New York City, United States. In Mod Pathol, Feb 2016
Overall, 13 genes had significantly increased CpG methylation in gastric cancer vs non-metaplastic mucosa (BRINP1, CDH11, CHFR, EPHA5, EPHA7, FGF2, FLI1, GALR1, HS3ST2, PDGFRA, SEZ6L, SGCE, and SNRPN).
Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma.
Ushijima et al., Tokyo, Japan. In Mol Carcinog, Feb 2016
The cell cycle was deregulated by mutations of CDKN2A (9%), deletions of CDKN2A and RB1 (32%), and by aberrant methylation of CDKN2A and CHFR (9%).
Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality.
Hoheisel et al., Heidelberg, Germany. In N Biotechnol, Jan 2016
We observed significant variation in the expression of the E3 ubiquitin-protein ligase (CHFR) as well as the glutamate receptor interacting protein 2 (GRIP2), for example, always with more than one of the scFvs binding to these targets.
CHFR is important for the survival of male premeiotic germ cells.
Yu et al., Hangzhou, China. In Cell Cycle, Dec 2015
CHFR was recently shown to participate in DNA damage response, but it remains to be established if CHFR is required for male fertility.
Identification of epistatic interactions through genome-wide association studies in sporadic medullary and juvenile papillary thyroid carcinomas.
Borrego et al., Sevilla, Spain. In Bmc Med Genomics, 2014
RESULTS: We have identified two significant epistatic gene interactions in sMTC (CHFR-AC016582.2
Carcinogenic mechanisms of endometrial cancer: involvement of genetics and epigenetics.
Aoki et al., Tokyo, Japan. In J Obstet Gynaecol Res, 2014
Possible carcinogenic mechanisms include imbalance between endometrial proliferation by unopposed estrogen and the mismatch repair (MMR) system; hypermethylation of the MMR gene hMLH1; mutation of PTEN, β-catenin and K-ras genes in type I endometrial cancer and of HER-2/neu and p53 genes in type II endometrial cancer; hypermethylation of SPRY2, RASSF1A, RSK4, CHFR and CDH1; and methylation of tumor suppressor microRNAs, including miR-124, miR-126, miR-137, miR-491, miR-129-2 and miR-152.
Emerging evidence for CHFR as a cancer biomarker: from tumor biology to precision medicine.
van Engeland et al., Amsterdam, Netherlands. In Cancer Metastasis Rev, 2014
In this review, we summarize the evidence for a promising cancer biomarker: checkpoint with forkhead and ring finger domains (CHFR).
RNA interference targeting CHFR enhances taxol chemosensitivity in endometrial cancer cells.
Shen et al., Guangzhou, China. In Oncol Rep, 2012
suppression of CHFR induced a significant increase of the mitotic index and much lower numbers of cells at the G2/M phase in both cells treated with taxol, indicating mitotic checkpoint impairment
CHFR: a key checkpoint component implicated in a wide range of cancers.
Yeong et al., Singapore, Singapore. In Cell Mol Life Sci, 2012
CHFR is thought to contribute towards regulating mitotic entry and possible explanations for contradictory observations published on the functions and regulation of CHFR are presented. [review]
CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation.
Tokino et al., Sapporo, Japan. In J Biol Chem, 2012
The interaction between CHFR and PARP-1 plays an important role in cell cycle regulation and cancer therapeutic strategies.
SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking CHFR mediated ubiquitination and degradation of its major components.
Seong et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
CHFR interacts with BRG1, SNF5, and BAF60a of the SWI/SNF-like BAF complex and ubiquitinates them to target for degradation through a proteasome-mediated pathway; SRG3 stabilizes these components by blocking their interaction with CHFR.
[Aberrant promoter hypermethylation of CHFR in nasopharyngeal carcinoma].
Zhang et al., Nanning, China. In Lin Chuang Er Bi Yan Hou Ke Za Zhi, 2011
CHFR is epigenetically inactivated by promoter methylation in nasopharyngeal carcinoma.
Protected from the inside: endogenous histone deacetylase inhibitors and the road to cancer.
Gulino et al., Roma, Italy. In Biochim Biophys Acta, 2011
Recent evidence has demonstrated that the tumor suppressors HIC1 and DBC1 induce direct repression of Sirt1 function, whereas Chfr and REN(KCTD11/KASH family) downregulate HDAC1, by inducing its ubiquitin-dependent degradation.
Epigenetic drivers of genetic alterations.
Suzuki et al., Sapporo, Japan. In Adv Genet, 2009
Epigenetic inactivation of MGMT is often associated with G:C-to-A:T mutations in K-ras and p53, while epigenetic inactivation of BRCA1, WRN, FANCF, and CHFR impairs the machinery involved in maintaining genomic integrity.
Chfr is linked to tumour metastasis through the downregulation of HDAC1.
Seol et al., Seoul, South Korea. In Nat Cell Biol, 2009
Chfr functions as a tumour suppressor by regulating HDAC1.
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins.
West et al., London, United Kingdom. In Nature, 2008
interaction of poly(ADP-ribose) with a PBZ motif in two representative human proteins, APLF (aprataxin PNK-like factor) and CHFR (checkpoint protein with FHA and RING domains)
Chfr is required for tumor suppression and Aurora A regulation.
Chen et al., Rochester, United States. In Nat Genet, 2005
Downregulation of Chfr contributes to tumorigenesis by controlling the expression levels of Aurora A.
Chfr defines a mitotic stress checkpoint that delays entry into metaphase.
Halazonetis et al., Philadelphia, United States. In Nature, 2000
Here we describe the chfr gene, which is inactivated owing to lack of expression or by mutation in four out of eight human cancer cell lines examined.
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