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Ceramide kinase

ceramide kinase, CERK
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: ACID, V1a, CAN, Cer, HAD
Papers on ceramide kinase
Caged ceramide 1-phosphate (C1P) analogs: Novel tools for studying C1P biology.
Ordoñez et al., Bilbao, Spain. In Chem Phys Lipids, Jan 2016
Ceramide 1-phosphate (C1P) is a bioactive sphingolipid metabolite that is produced in cells by the action of ceramide kinase (CerK) acting upon ceramide, and is also found in the circulation.
Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells.
Gomez-Muñoz et al., Bilbao, Spain. In Biochem Pharmacol, Jan 2016
Pancreatic cancer cells engineered to overexpress ceramide kinase (CerK), the enzyme responsible for C1P biosynthesis in mammalian cells, showed enhanced spontaneous cell migration that was potently blocked by treatment with the selective CerK inhibitor NVP-231, or by treatment with specific CerK siRNA.
Evidence for ACD5 ceramide kinase activity involvement in Arabidopsis response to cold stress.
Guillas et al., Paris, France. In Plant Cell Environ, Dec 2015
Ceramide kinase activity, gene expression and growth phenotype were determined in unstressed and cold-stressed wild type (WT) and Arabidopsis ceramide kinase mutant acd5.
Integrated targeted sphingolipidomics and transcriptomics reveal abnormal sphingolipid metabolism as a novel mechanism of the hepatotoxicity and nephrotoxicity of triptolide.
Zhang et al., Beijing, China. In J Ethnopharmacol, Aug 2015
Several enzymes, including kdsr, CerS2, CerS4, CerS5 and CerS6 in the liver and Cerk in the kidney were probably responsible for the TP-induced toxic effect, identifying them as possible novel therapeutic targets.
The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death.
Huwiler et al., Bern, Switzerland. In Br J Pharmacol, 2014
BACKGROUND AND PURPOSE: Ceramide kinase (CerK) catalyzes the generation of ceramide-1-phosphate which may regulate various cellular functions, including inflammatory reactions and cell growth.
Ceramide kinase promotes tumor cell survival and mammary tumor recurrence.
Chodosh et al., Philadelphia, United States. In Cancer Res, 2014
We now report that ceramide kinase (Cerk) is required for mammary tumor recurrence following HER2/neu pathway inhibition and is spontaneously upregulated during tumor recurrence in multiple genetically engineered mouse models for breast cancer.
Ceramide and its metabolites modulate time-dependently the activity of the Na⁺/K⁺ ATPase in HepG2 cells.
Dakroub et al., Beirut, Lebanon. In Int J Biochem Cell Biol, 2014
This stimulation was maintained in the simultaneous presence of an inhibitor of ceramidase (CAY 10466) but disappeared when ceramide kinase was inhibited, suggesting a role of ceramide-1-phosphate (cer-1-P) in the observed effect.
Loss of ceramide kinase in Arabidopsis impairs defenses and promotes ceramide accumulation and mitochondrial H2O2 bursts.
Yao et al., Guangzhou, China. In Plant Cell, 2014
Arabidopsis thaliana plants that lack ceramide kinase, encoded by ACCELERATED CELL DEATH5 (ACD5), display spontaneous programmed cell death late in development and accumulate substrates of ACD5.
Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts.
Chalfant et al., Richmond, United States. In J Lipid Res, 2014
Specifically, fibroblasts isolated from mice with the known anabolic enzyme for C1P, ceramide kinase (CERK), ablated (CERK(-/-) mice) and their wild-type littermates (CERK(+/+)) were subjected to in vitro wound-healing assays.
Ceramide kinase contributes to proliferation but not to prostaglandin E2 formation in renal mesangial cells and fibroblasts.
Huwiler et al., Bern, Switzerland. In Cell Physiol Biochem, 2013
BACKGROUND/AIMS: Ceramide kinase (CerK) catalyzes the generation of the sphingolipid ceramide-1-phosphate (C1P) which regulates various cellular functions including cell growth and death, and inflammation.
Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids.
Patel et al., New York City, United States. In Nature, 2013
C1P produced by ceramide kinase is an activator of group IVA cytosolic phospholipase A2α (cPLA2α), the rate-limiting releaser of arachidonic acid used for pro-inflammatory eicosanoid production, which contributes to disease pathogenesis in asthma or airway hyper-responsiveness, cancer, atherosclerosis and thrombosis.
New insights on the role of ceramide 1-phosphate in inflammation.
Trueba et al., Bilbao, Spain. In Biochim Biophys Acta, 2013
The present review highlights novel aspects on the regulation of inflammation by sphingolipids, with special emphasis to the role played by ceramide 1-phosphate and ceramide kinase, the enzyme responsible for its biosynthesis, in inflammatory responses.
The role of ceramide-1-phosphate in biological functions.
Chalfant et al., Richmond, United States. In Handb Exp Pharmacol, 2012
In mammalian cells, cermide-1-phosphate (C1P) is produced via the ATP-dependent mechanism of converting ceramide to C1P by the enzyme, ceramide kinase (CERK).
Ceramide kinase regulates TNFα-stimulated NADPH oxidase activity and eicosanoid biosynthesis in neuroblastoma cells.
Kuhn et al., Fairbanks, United States. In Cell Signal, 2012
TNF-alpha exposure of human SH-SY5Y neuroblastoma caused a profound increase in CERK activity.
Ceramide kinase deficiency improves diet-induced obesity and insulin resistance.
Igarashi et al., Japan. In Febs Lett, 2012
role of ceramide kinase in obesity and insulin resistance
Alteration of ceramide 1-O-functionalization as a promising approach for cancer therapy.
Andrieu-Abadie et al., Toulouse, France. In Anticancer Agents Med Chem, 2012
The effects of enzyme inhibitors of sphingomyelin synthase, ceramide kinase and glucosylceramide synthase on cancer cell proliferation, sensitivity to chemotherapeutics, induction of apoptosis or growth of xenografts are presented.
Ceramide kinase regulates the production of tumor necrosis factor α (TNFα) via inhibition of TNFα-converting enzyme.
Chalfant et al., Richmond, United States. In J Biol Chem, 2012
Results indicate that C1P produced by CERK has a negative effect on the processing/secretion of TNFalpha via modulation of TACE activity.
Role of cytosolic phospholipase A(2)α in cell rounding and cytotoxicity induced by ceramide-1-phosphate via ceramide kinase.
Murayama et al., Chiba, Japan. In Arch Biochem Biophys, 2011
Expression of hCERK enhanced ceramide-1-phosphate formation and release of arachidonic acid in Ca(2+) ionophore-stimulated cells.
Ceramide kinase: the first decade.
Bornancin, Basel, Switzerland. In Cell Signal, 2011
It has been some 20 years since the initial discovery of ceramide 1-phosphate (C1P) and nearly a decade since ceramide kinase (CERK) was cloned.
A differential role for ceramide kinase in antigen/FcɛRI-mediated mast cell activation and function.
Fidock et al., Kent, United States. In Clin Exp Allergy, 2011
We have identified a differential role for ceramide kinase in mast-cell activation
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