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UGCG UDP-glucose ceramide glucosyltransferase

ceramide glucosyltransferase
Top mentioned proteins: ACID, STEP, HAD, CAN, V1a
Papers on ceramide glucosyltransferase
STAT3 promotes CD1d-mediated lipid antigen presentation by regulating a critical gene in glycosphingolipid biosynthesis.
Brutkiewicz et al., Indianapolis, United States. In Immunology, Nov 2015
Consistent with this observation, in APCs where STAT3 was knocked down, dramatically decreased levels of UDP glucose ceramide glucosyltransferase (UGCG), an enzyme involved in the first step of glycosphingolipid biosynthesis, were observed.
Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death.
Galmarini et al., Colmenar Viejo, Spain. In Plos One, 2014
Furthermore, GM95, a mutant derivative from B16 mouse melanoma cells lacking ceramide glucosyltransferase (UGCG) activity and thus the synthesis of glycosylceramides, was also resistant to elisidepsin.
Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing.
Jennemann et al., In Hum Mol Genet, 2013
Tamoxifen (TAM)-induced deletion of the endogenous GlcCer-synthesizing enzyme UDP-glucose:ceramide glucosyltransferase (UGCG) in keratin K14-positive cells resulted in epidermal GlcCer depletion.
Altered phospholipid molecular species and glycolipid composition in brain, liver and fibroblasts of Zellweger syndrome.
Mizuguchi et al., Tokyo, Japan. In Neurosci Lett, 2013
In neuronal F3-Ngn1 cells, ACOX1 and GNPAT silencing up-regulated ceramide galactosyltransferase (UGT8) mRNA expression, and down-regulated UDP-glucose ceramide glucosyltransferase (UGCG).
A small molecule inhibitor of Bcl-2, HA14-1, also inhibits ceramide glucosyltransferase.
Ichikawa et al., Niigata, Japan. In Biochem Biophys Res Commun, 2013
In the course of searching for a ceramide glucosyltransferase inhibitor that catalyzes the first glycosylation step of glycosphingolipid synthesis, we unexpectedly found that HA-14-1 also has the ability to inhibit ceramide glucosyltransferase.
Cell-specific in vivo functions of glycosphingolipids: lessons from genetic deletions of enzymes involved in glycosphingolipid synthesis.
Gröne et al., Heidelberg, Germany. In Prog Lipid Res, 2013
Thus, UDP-glucose:ceramide glucosyltransferase (Ugcg), catalyzing the basic step of the glucosylceramide-based GSL-biosynthesis, was genetically disrupted.
Gangliosides have a functional role during rotavirus cell entry.
Isa et al., Ecatepec, Mexico. In J Virol, 2013
The role of gangliosides in rotavirus cell entry was studied by silencing the expression of two key enzymes involved in their biosynthesis--the UDP-glucose:ceramide glucosyltransferase (UGCG), which transfers a glucose molecule to ceramide to produce glucosylceramide GlcCer, and the lactosyl ceramide-α-2,3-sialyl transferase 5 (GM3-s), which adds the first SA to lactoceramide-producing ganglioside GM3.
The lifetime of UDP-galactose:ceramide galactosyltransferase is controlled by a distinct endoplasmic reticulum-associated degradation (ERAD) regulated by sigma-1 receptor chaperones.
Su et al., Baltimore, United States. In J Biol Chem, 2013
The glycosphingolipid biosynthesis is initiated by monoglycosylation of ceramides, the action of which is catalyzed either by UDP-glucose:ceramide glucosyltransferase or by UDP-galactose:ceramide galactosyltransferase (CGalT).
Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.
Jennemann et al., Heidelberg, Germany. In Plos Biol, 2012
Consequently, mice with inducible forebrain neuron-specific deletion of the UDP-glucose:ceramide glucosyltransferase gene (Ugcg) display obesity, hypothermia, and lower sympathetic activity.
B-cell receptor triggers drug sensitivity of primary CLL cells by controlling glucosylation of ceramides.
Frenzel et al., Köln, Germany. In Blood, 2012
We identified BCR engagement to catalyze the crucial modification of ceramide to glucosylceramide via UDP-glucose ceramide glucosyltransferase (UGCG).
Glycosphingolipids are essential for intestinal endocytic function.
Gröne et al., Heidelberg, Germany. In J Biol Chem, 2012
The enzyme UDP-glucose ceramide glucosyltransferase (Ugcg) catalyzes the initial step of GSL biosynthesis.
Characterization of genes involved in ceramide metabolism in the Pacific oyster (Crassostrea gigas).
Roberts et al., Seattle, United States. In Bmc Res Notes, 2011
RESULTS: Several genes were identified including full-length sequences characterized for serine palmitoyltransferase-1, 3-ketodihydrosphingosine reductase, acid ceramidase, and ceramide glucosyltransferase.
Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses.
Platt et al., Oxford, United Kingdom. In Glycobiology, 2005
An understanding of the molecular mechanism for the inhibition of the key enzyme in GSL biosynthesis, ceramide glucosyltransferase (CGT) by N-alkylated imino sugars, has also lead to compound design for improvements to inhibitory potency, bioavailability, enzyme selectivity, and biological safety.
[Functional glycoconjugates involved in cellular interaction].
Hidari, Shizuoka, Japan. In Yakugaku Zasshi, 2003
We first examined the involvement of the complex sphingolipids in cell-substratum adhesion using GM-95, a mutant cell line deficient in glycosphingolipids (GSLs) due to the lack of ceramide glucosyltransferase activity.
Goa et al., Auckland, New Zealand. In Drugs, 2002
Miglustat is an orally administered ceramide glucosyltransferase inhibitor which prevents the lysosomal accumulation of glucocerebroside that occurs in patients with Gaucher's disease.
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