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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Centrosomal protein 55kDa

Cep55, c10orf3, Centrosomal protein 55, CT111, centrosomal protein 55kDa
Top mentioned proteins: CAN, TSG101, STEP, Plk1, Akt
Papers on Cep55
Upregulation of centrosomal protein 55 is associated with unfavorable prognosis and tumor invasion in epithelial ovarian carcinoma.
Zhang et al., Guangzhou, China. In Tumour Biol, Dec 2015
UNASSIGNED: Centrosomal protein 55 (CEP55) is a cell cycle regulator implicated in development of certain cancers.
Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.
Wiggans et al., Saint Paul, United States. In Plos Genet, Nov 2015
Two novel loci, NEK9 and REC114, were associated with recombination rate in both sexes, whereas three loci, MSH4, SMC3 and CEP55, affected recombination rate in females only.
Identification of biomarkers with a tumor stage-dependent expression and exploration of the mechanism involved in laryngeal squamous cell carcinoma.
Jang et al., Shenyang, China. In Oncol Rep, Nov 2015
In the co-expressed network, BUB1, TTK, E2F1 and CEP55 were prominent, with E2F1 being predicted as a TSG and CEP55 as an oncogene.
Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells.
Lee et al., Seoul, South Korea. In Proc Natl Acad Sci U S A, Nov 2015
To gain insights into the structural organization of TEX14 at the midbody, we have determined the crystal structures of the EABR [endosomal sorting complex required for transport (ESCRT) and ALIX-binding region] of CEP55 bound to the TEX14 peptide (or its chimeric peptides) and performed functional characterization of the CEP55-TEX14 interaction by multiexperiment analyses.
Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish.
Khanna et al., Brisbane, Australia. In Faseb J, May 2015
CEP55 was initially described as a centrosome- and midbody-associated protein and a key mediator of cytokinesis.
Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis.
Khanna et al., Brisbane, Australia. In Oncogene, May 2015
UNASSIGNED: CEP55 was initially identified as a pivotal component of abscission, the final stage of cytokinesis, serving to regulate the physical separation of two daughter cells.
Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.
Gingras et al., Toronto, Canada. In Mol Cell Proteomics, Apr 2015
Interestingly, myotubularin-related protein 3 and myotubularin-related protein 4 do not exert their effects through lipid regulation at the midbody, but regulate abscission during early mitosis, by interacting with the mitotic kinase polo-like kinase 1, and with centrosomal protein of 55 kDa (CEP55), an important regulator of abscission.
Cep55 regulates spindle organization and cell cycle progression in meiotic oocyte.
Sun et al., Zhengzhou, China. In Sci Rep, 2014
Cep55 is a relatively novel member of the centrosomal protein family.
CEP proteins: the knights of centrosome dynasty.
Purohit et al., Vellore, India. In Protoplasma, 2013
Moreover, CEP27, CEP55, CEP70, CEP110, CEP120, CEP135, CEP192, CEP250, CEP290, and CEP350 also seem promising for future drug discovery approaches.
Knowing when to cut and run: mechanisms that control cytokinetic abscission.
Martin-Serrano et al., London, United Kingdom. In Trends Cell Biol, 2013
Here, we review recent evidence suggesting that proper abscission timing is coordinated by cytoskeletal rearrangements and recruitment of regulators of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery such as CEP55 and MIT-domain-containing protein 1 (MITD1) to the abscission site.
BRCA2 localization to the midbody by filamin A regulates cep55 signaling and completion of cytokinesis.
Couch et al., Rochester, United States. In Dev Cell, 2012
At the midbody, BRCA2 influences the recruitment of endosomal sorting complex required for transport (ESCRT)-associated proteins, Alix and Tsg101, and formation of CEP55-Alix and CEP55-Tsg101 complexes during abscission.
Centrosomal protein 55 (Cep55) stability is negatively regulated by p53 protein through Polo-like kinase 1 (Plk1).
Ouyang et al., Taiwan. In J Biol Chem, 2012
the existence of a p53-Plk1-Cep55 axis in which p53 negatively regulates expression of Cep55, through Plk1 which, in turn, is a positive regulator of Cep55 protein stability.
FLJ10540 is associated with tumor progression in nasopharyngeal carcinomas and contributes to nasopharyngeal cell proliferation, and metastasis via osteopontin/CD44 pathway.
Hwang et al., Kao-hsiung, Taiwan. In J Transl Med, 2011
FLJ10540 may be critical regulator of disease progression in nasopharygeal carcinoma, and the underlying mechanism may involve in the osteopontin/CD44 pathway.
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity.
Doxsey et al., Worcester, United States. In Nat Cell Biol, 2011
MB(d) loss accompanies stem-cell differentiation, and involves autophagic degradation mediated by binding of the autophagic receptor NBR1 to the midbody protein CEP55.
Germ cell intercellular bridges.
Matzuk et al., Houston, United States. In Cold Spring Harb Perspect Biol, 2011
TEX14 acts to impede the terminal steps of abscission by competing for essential component CEP55, blocking its interaction in nongerm cells with ALIX and TSG101.
Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission.
Barr et al., Liverpool, United Kingdom. In J Cell Biol, 2010
Data show that Plk1 activity negatively regulates Cep55 to ensure orderly abscission factor recruitment and ensures that this occurs only once cell contraction has completed.
Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma.
Teh et al., London, United Kingdom. In Oral Oncol, 2010
Data provide strong evidence that CEP55 and HELLS may be used in conjunction with FOXM1 as a biomarker set for early cancer detection and indicators of malignant conversion and progression.
Cytokinesis and cancer: Polo loves ROCK'n' Rho(A).
Xu et al., Beijing, China. In J Genet Genomics, 2010
We review current understandings of the interplay between Plk1, RhoA proteins and other proteins (e.g., NudC, MKLP2, PRC1, CEP55) involved in cytokinesis, with particular emphasis of its clinical implications in cancer.
Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55.
Hurley et al., Bethesda, United States. In Science, 2008
crystal structure of the ESCRT and ALIX-binding region (EABR) of CEP55 bound to an ALIX peptide at a resolution of 2.0 angstroms; structure shows that EABR forms an aberrant dimeric parallel coiled coil
Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery.
Martin-Serrano et al., London, United Kingdom. In Science, 2007
study shows that two proteins involved in HIV-1 budding-Tsg101, a subunit of the endosomal sorting complex required for transport I (ESCRT-I), & Alix, an ESCRT-associated protein-were recruited to the midbody during cytokinesis by interaction with Cep55
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