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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Centrin, EF-hand protein, 3

centrin 3, CETN3
The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Centrin, ACID, HAD, POLYMERASE, Aurora
Papers on centrin 3
Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes centrin 2 function.
Fisk et al., Liverpool, United Kingdom. In Mol Biol Cell, Dec 2015
We previously identified centrin 2 and centrin 3 (Cetn2 and Cetn3) as substrates of the protein kinase Mps1.
Centrin-2 (Cetn2) mediated regulation of FGF/FGFR gene expression in Xenopus.
Klymkowsky et al., Boulder, United States. In Sci Rep, 2014
Two distinct Cetn subtypes, Cetn2-like and Cetn3-like, have been recognized and implicated in a range of cellular processes.
The Leber congenital amaurosis protein AIPL1 and EB proteins co-localize at the photoreceptor cilium.
van der Spuy et al., London, United Kingdom. In Plos One, 2014
However, both AIPL1 and the EB proteins, EB1 and EB3, co-localized with centrin-3 in the connecting cilium of photoreceptor cells.
Disruption of the retinitis pigmentosa 28 gene Fam161a in mice affects photoreceptor ciliary structure and leads to progressive retinal degeneration.
Langmann et al., Köln, Germany. In Hum Mol Genet, 2014
Co-immunolabeling experiments demonstrated reduced expression and mislocalization of centrin 3 and disturbed targeting of the Fam161a interactors lebercilin and Cep290, which were restricted to the basal body and proximal connecting cilium in Fam161a(GT/GT) retinas.
CETN1 is a cancer testis antigen with expression in prostate and pancreatic cancers.
Mooney et al., Baltimore, United States. In Biomark Res, 2012
Through the mining of publicly available microarray data, we discovered that human CETN1 expression but not CETN2 or CETN3 is restricted to the testis.
The two human centrin homologues have similar but distinct functions at Tetrahymena basal bodies.
Winey et al., Boulder, United States. In Mol Biol Cell, 2012
In this paper, we show that the Tetrahymena centrin 2 (Cen2), a human centrin 3 homologue, has functions similar to Cen1 in basal body orientation, maintenance, and separation.
Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial.
Holick et al., Boston, United States. In Plos One, 2012
Seventeen vitamin D-regulated genes with new candidate vitamin D response elements including TRIM27, CD83, COPB2, YRNA and CETN3 which have been shown to be important for transcriptional regulation, immune function, response to stress and DNA repair were identified.
MagFRET: the first genetically encoded fluorescent Mg2+ sensor.
Merkx et al., Eindhoven, Netherlands. In Plos One, 2012
This sensor is based on the high-affinity Mg(2+) binding domain of human centrin 3 (HsCen3), which undergoes a transition from a molten-globular apo form to a compactly-folded Mg(2+)-bound state.
Whole blood genome-wide gene expression profile in males after prolonged wakefulness and sleep recovery.
Tufik et al., São Paulo, Brazil. In Physiol Genomics, 2012
In silico validation of alterations in the expression of CETN3, DNAJC, and CEACAM genes confirmed previous findings related to the molecular effects of sleep deprivation.
Differential expression of centrosome-associated proteins in human brain tumors: a possible role of hNinein isoform 6 in cell differentiation.
Howng et al., Kao-hsiung, Taiwan. In Biofactors, 2012
Specifically, centrin 2 and centrin 3 expression levels were classified as moderate or abundant in >97% of samples in the meningioma group, 63% of astrocytomas, >83% of metastatic and pituitary tumors.
Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins.
Morrison et al., Galway, Ireland. In J Cell Biol, 2011
However, centrin deficiency made DT40 cells highly sensitive to ultraviolet (UV) irradiation, with Cetn3 deficiency exacerbating the sensitivity of Cetn4/Cetn2 double mutants.
Differential expression of centrosomal proteins at different stages of human glioma.
Hong et al., Kao-hsiung, Taiwan. In Bmc Cancer, 2009
Comparing with normal human brain tissue, most of the mRNAs expression in gliomas for centrosomal structural proteins, including centrin 3, gamma-tubulin, and hNinein isoforms 1, 2, 5 and 6, Aurora A and Aurora B were elevated.
A novel microdeletion syndrome involving 5q14.3-q15: clinical and molecular cytogenetic characterization of three patients.
Rauch et al., Bonn, Germany. In Eur J Hum Genet, 2009
It included five genes: CETN3, AC093510.2,
Reorganization of centrosomal marker proteins coincides with epithelial cell differentiation in the vertebrate lens.
Prescott et al., Dundee, United Kingdom. In Exp Eye Res, 2007
We have investigated the fate of the centrosomal MTOCs during cellular differentiation in the bovine lens using gamma-tubulin, ninein, centrin 2 and centrin 3 as markers.
Calcium and magnesium binding to human centrin 3 and interaction with target peptides.
Craescu et al., Genève, Switzerland. In Biochemistry, 2005
could be classified as a Ca(2+) sensor protein
The cloning and expression characterization of the centrosome protein genes family (centrin genes) in rat testis.
Han et al., Beijing, China. In Sci China C Life Sci, 2002
Centrin-2 and centrin-3 are highly expressed in spermatogonia and their mRNA level decreases markedly when meiosis occurs.
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