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ArfGAP with dual PH domains 2

centaurin-alpha2, CENTA2, HSA272195, cent-B
phosphatidylinositide-binding protein [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: NF1, SUZ12, centaurin-alpha1, Alpha-1, V1a
Papers on centaurin-alpha2
Identification of genes potentially involved in the increased risk of malignancy in NF1-microdeleted patients.
Bi├Ęche et al., Paris, France. In Mol Med, 2011
More interestingly, two genes were significantly downregulated (RNF135 and CENTA2) in tumor Schwann cells from MPNST biopsies and in MPNST cell lines.
Expression analysis of genes lying in the NF1 microdeletion interval points to four candidate modifiers for neurofibroma formation.
Kaufmann et al., Ulm, Germany. In Neurogenetics, 2009
Expression analysis of 13 genes of the microdeletion region in dermal neurofibromas and other tissues revealed four candidates for the modification of neurofibroma formation: CENTA2, RAB11FIP4, C17orf79, and UTP6.
PI-3-kinase-dependent membrane recruitment of centaurin-alpha2 is essential for its effect on ARF6-mediated actin cytoskeleton reorganisation.
Yun et al., Bristol, United Kingdom. In J Cell Sci, 2007
GTPase activating proteins (GAPs) of the centaurin family regulate the actin cytoskeleton and vesicle trafficking through inactivation of the ADP-ribosylation factor (ARF) family of small GTP-binding proteins.
Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity.
Reiser et al., Magdeburg, Germany. In J Neurochem, 2006
We further detected that centaurin-alpha2, a protein that is highly homologous to p42IP4/centaurin-alpha1 and expressed ubiquitously, also binds to NRDc.
Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval.
Riva et al., Milano, Italy. In Ann Hum Genet, 2005
Following in silico analysis of the deleted region, we found two genes known to be expressed in adult heart, the Joined to JAZF1 (SUZ12) and the Centaurin-alpha 2 (CENTA2) genes, and seven other genes with poorly defined patterns of expression and function.
Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins.
Reiser et al., Magdeburg, Germany. In J Neurochem, 2004
The human gene for centaurin alpha 2 is located on chromosome 17, position 17q11.2, near the neurofibromatosis 1 (NF1) locus and concentrated at the plasma membrane.
Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse.
Kehrer-Sawatzki et al., Martinsried, Germany. In Genes Chromosomes Cancer, 2003
Moreover, we completed the genomic organization and cDNA structure of all functional genes, CYTOR4, FLJ12735, FLJ22729, CENTA2, MGC13061, NF1, OMG, EVI2B, EVI2A, KIAA1821, MGC11316, HCA66, KIAA0160, and WI-12393, from this region.
Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle.
Holman et al., Bath, United Kingdom. In Eur J Cell Biol, 2002
Results describe the cloning, expression and characterisation of centaurin-alpha2 from a rat adipocyte cDNA library.
Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions.
Kehrer-Sawatzki et al., Martinsried, Germany. In Am J Hum Genet, 2001
Since patients with the NF1 large-deletion syndrome have a significantly increased risk of neurofibroma development and mental retardation, hemizygosity for genes from the deleted region around the neurofibromin locus (CYTOR4, FLJ12735, FLJ22729, HSA272195 (centaurin-alpha2), NF1, OMGP, EVI2A, EVI2B, WI-9521, HSA272196, HCA66, KIAA0160, and WI-12393) may contribute to the severe phenotype of these patients.
Autoantibodies detectable in the sera of silicosis patients. The relationship between the anti-topoisomerase I antibody response and HLA-DQB1*0402 allele in Japanese silicosis patients.
Hydoh et al., Kurashiki, Japan. In Sci Total Environ, 2001
Antibodies directed to RNP, ssDNA, dsDNA and cent-B were not detected among the anti-topo I positive patients.
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