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Centromere protein Q

CENP-Q, C6orf139
CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: MLF1IP, CENP-P, Gli, NRIF3, Mis6
Papers on CENP-Q
Mammalian Polo-like kinase 1 (Plk1) promotes proper chromosome segregation by phosphorylating and delocalizing the PBIP1·CENP-Q complex from kinetochores.
Lee et al., Seoul, South Korea. In J Biol Chem, Apr 2015
Plk1 is self-recruited to prekinetochores/kinetochores by phosphorylating and binding to the Thr-78 motif of a kinetochore scaffold protein, PBIP1 (also called CENP-U/50), which forms a stable complex with another kinetochore component, CENP-Q.
Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways.
McAinsh et al., Coventry, United Kingdom. In J Cell Sci, 2015
Here, we show that CENP-Q - a subunit of the CENP-O complex (comprising CENP-O, CENP-P, CENP-Q and CENP-U) that targets polo-like kinase (Plk1) to kinetochores - is also required for the recruitment of CENP-E to kinetochores.
The CENP-O complex requirement varies among different cell types.
Fukagawa et al., Mishima, Japan. In Chromosome Res, 2014
CENP-U (CENP-50) is a component of the CENP-O complex, which includes CENP-O, CENP-P, CENP-Q, CENP-R, and CENP-U and is constitutively localized at kinetochores throughout the cell cycle in vertebrates.
A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A.
Westermann et al., Vienna, Austria. In J Cell Biol, 2014
We show that the conserved kinetochore subunits Ame1(CENP-U) and Okp1(CENP-Q) form a DNA-binding complex that associates with the microtubule-binding KMN network via a short Mtw1 recruitment motif in the N terminus of Ame1.
Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly.
Allshire et al., Edinburgh, United Kingdom. In Open Biol, 2013
Eic1 also associates with Fta7(CENP-Q/Okp1), Cnl2(Nkp2) and Mal2(CENP-O/Mcm21), components of the constitutive CCAN/Mis6/Ctf19 complex.
New centromere autoantigens identified in systemic sclerosis using centromere protein microarrays.
Wu et al., Beijing, China. In J Rheumatol, 2013
Of them, 5 [CENP-P, CENP-Q, CENP-M (isoform I), CENP-J, and CENP-T] are novel, among which CENP-P and CENP-Q showed high sensitivities in ACA-positive SSc sera of 34.3% and 28.6%, respectively.
Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex.
Diekmann et al., Jena, Germany. In Plos One, 2011
Surprisingly, we then find that during late S-phase, following the kinetochore-binding step, both CENP-Q and -U but not -R undergo oligomerization.
The ABCs of CENPs.
Fukagawa et al., Mishima, Japan. In Chromosoma, 2011
Onto centromeric CENP-A chromatin is assembled the so-called constitutive centromere-associated network (CCAN) of 16 proteins distributed in several functional groups as follows: CENP-C, CENP-H/CENP-I/CENP-K/, CENP-L/CENP-M/CENP-N, CENP-O/CENP-P/CENP-Q/CENP-R/CENP-U(50), CENP-T/CENP-W, and CENP-S/CENP-X.
Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores.
Lee et al., Bethesda, United States. In J Biol Chem, 2011
Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores.
Molecular control of kinetochore-microtubule dynamics and chromosome oscillations.
Meraldi et al., Zürich, Switzerland. In Nat Cell Biol, 2010
We also show that the abundance of the CENP-A NAC/CAD subunits CENP-H and CENP-I dynamically change on individual sister kinetochores in vivo, because they preferentially bind the sister kinetochore attached to growing microtubules, and that one other subunit, CENP-Q, binds microtubules in vitro.
The human CENP-A centromeric nucleosome-associated complex.
Cleveland et al., San Diego, United States. In Nat Cell Biol, 2006
Seven new CENP-A-nucleosome distal (CAD) centromere components (CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) are identified as assembling on the CENP-A NAC.
Identification of novel genes associated with the response to 5-FU treatment in gastric cancer cell lines using a cDNA microarray.
Kim et al., Taejŏn, South Korea. In Cancer Lett, 2004
Of these genes, the expression levels of ZFP100, 4F2hc, FLJ11021, CSTF3, PPP1R14A, DDB2, C6orf139, CDKN1A, HOXC11 and FLJ38860 were confirmed by semi-quantitative RT-PCR.
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