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Centromere protein B, 80kDa

CENP-B, Centromere Protein B
This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: Gli, Phosphogluconate Dehydrogenase, CENP-C, CAN, HAD
Papers using CENP-B antibodies
CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis
Zachos George et al., In The Journal of Cell Biology, 2000
... Monoclonal antibodies against Chk1 (G-4), Myc (9E10), and Survivin (D-8) and polyclonal antibodies against CENP-B and pH3 were obtained from Santa Cruz Biotechnology, Inc ...
Papers on CENP-B
Comparison of the clinical utility of the Elia CTD Screen to indirect immunofluorescence on Hep-2 cells.
Reicht et al., In Clin Chem Lab Med, Jan 2016
ECS had a better detection rate for anti-dsDNA, -SSA/Ro, -SSB/La, -U1RNP and -Jo-1 antibodies, whereas IIF was superior in the detection of anti-CENP-B antibodies as well as anti-histone, -nucleosome and -Pl-12 antibodies, which are not included in the ECS antigen panel.
Interpretation of an Extended Autoantibody Profile in a Well-Characterized Australian Systemic Sclerosis (Scleroderma) Cohort Using Principal Components Analysis.
Walker et al., Adelaide, Australia. In Arthritis Rheumatol, Dec 2015
METHODS: Serum from 505 Australian SSc patients were analyzed with a commercial line immunoassay (EuroLine; Euroimmun) for autoantibodies to centromere proteins CENP-A and CENP-B, RNA polymerase III (RNAP III; epitopes 11 and 155), the 90-kd nucleolar protein NOR-90, fibrillarin, Th/To, PM/Scl-75, PM/Scl-100, Ku, topoisomerase I (topo I), tripartite motif-containing protein 21/Ro 52, and platelet-derived growth factor receptor.
Alteration/Deficiency in Activation 3 (ADA3) Protein, a Cell Cycle Regulator, Associates with the Centromere through CENP-B and Regulates Chromosome Segregation.
Band et al., Omaha, United States. In J Biol Chem, Dec 2015
Both an in vivo proximity ligation assay and immunofluorescence studies confirmed the association of ADA3 with CENP-B protein, a highly conserved centromeric protein that binds to the 17-bp DNA sequences on α-satellite DNA.
Suppression of Meiotic Recombination by CENP-B Homologs in Schizosaccharomyces pombe.
Cam et al., Boston, United States. In Genetics, Nov 2015
Here, we show that the rates of HR across Tf2s are similar to a genome average but substantially increase in mutants deficient for the CENP-B homologs.
Organization and evolution of Gorilla centromeric DNA from old strategies to new approaches.
Ventura et al., Bari, Italy. In Sci Rep, 2014
Finally, the discovery of a new 189 bp monomer type in gorilla centromeres unravels clues to the role of the centromere protein B, paving the way to solve the significance of the centromere DNA's essential repetitive nature in association with its function and the peculiar evolution of the α-satellite sequence.
Swapping CENP-A at the centromere.
Straight et al., Stanford, United States. In Nat Cell Biol, 2013
Gene replacement in human cells and fission yeast has now been used to show how CENP-A biochemically encodes centromere identity, as well as reveal an unexpected role for CENP-B in centromere function.
A two-step mechanism for epigenetic specification of centromere identity and function.
Cleveland et al., San Diego, United States. In Nat Cell Biol, 2013
Subsequently, nucleation of kinetochore assembly onto CATD-containing chromatin is shown to require either the amino- or carboxy-terminal tail of CENP-A for recruitment of inner kinetochore proteins, including stabilizing CENP-B binding to human centromeres or direct recruitment of CENP-C, respectively.
Diagnostic accuracy and predictive value of extended autoantibody profile in systemic sclerosis.
Bizzaro et al., Pordenone, Italy. In Autoimmun Rev, 2012
The sensitivity and the specificity of this assay were as follows: 30.5% and 97.3% for ACA (anti-CENP-B), 29.5% and 96% for ACA (anti-CENP-A), 20% and 99.3% for ATA, 5.7% and 99.3% for anti-RNAP III (RP-155), 5.2% and 100% for anti-RNP III (RP-11), 6.7% and 98% for anti-PMScl (PMScl-100), 10.9% and 93.3% for anti-PMScl (PMscl-75), 3.3% and 98.7% for anti-Th/To, 0.48% and 100% for AFA, 4.8% and 96.7% for anti-hUF/NOR-90, 4.7% and 96% for anti-Ku, 0.95% and 100% for anti-Platelet-Derived Growth Factor Receptor, and 18.1% and 50% for anti-Ro-52, respectively.
CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR.
Martienssen et al., New York City, United States. In Nature, 2011
Centromere-binding protein B (CENP-B) is a widely conserved DNA binding factor associated with heterochromatin and centromeric satellite repeats.
Anti-CENP-B antibodies are associated with prolonged survival in breast cancer.
Atalay et al., Ankara, Turkey. In Future Oncol, 2010
Anti-CENP-B autoantibodies in breast cancer patients prolong disease-free and overall survival.
Nuclear autoantigen CENP-B transactivation of the epidermal growth factor receptor via chemokine receptor 3 in vascular smooth muscle cells.
Raymond et al., Montréal, Canada. In Arthritis Rheum, 2009
CENP-B binding stimulated the cross-talk between CCR3 and epidermal growth factor receptor (EGFR) in human pulmonary artery smooth muscle cells.
Distribution of centromeric proteins and PARP-1 during mitosis and apoptosis.
Scovassi et al., Pavia, Italy. In Ann N Y Acad Sci, 2009
Study analyzed the distribution of PARP-1 and its interaction with CENP-B, -E, and -F during mitosis and apoptosis.
Centromeres: long intergenic spaces with adaptive features.
Dawe et al., Athens, United States. In Funct Integr Genomics, 2009
Tandem repeat arrays present in centromeres may have an origin in meiotic drive or other selfish patterns of evolution, as is the case for the CENP-B box and CENP-B protein in human.
Predictive value of antinuclear autoantibodies: the lessons of the systemic sclerosis autoantibodies.
Senécal et al., Montréal, Canada. In Autoimmun Rev, 2008
In this brief review, we answer these questions by excerpting data from the literature focused on the 4 major SSc specific autoantibodies (aAbs) to nuclear autoantigens (ANAs): anti-centromere (anti-CENP-B), anti-Th/To, anti-topoisomerase I (anti-topo I) and anti-RNA polymerase III (anti-RNAPIII).
Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B.
Diekmann et al., Jena, Germany. In J Biophotonics, 2008
Acceptor-bleaching FRET indicates that CENP-T directly associates with CENP-A and CENP-B.
Host genome surveillance for retrotransposons by transposon-derived proteins.
Grewal et al., Bethesda, United States. In Nature, 2008
Here we describe a genome surveillance mechanism for retrotransposons by transposase-derived centromeric protein CENP-B homologues of the fission yeast Schizosaccharomyces pombe.
CENP-B controls centromere formation depending on the chromatin context.
Masumoto et al., Nagoya, Japan. In Cell, 2008
Propose that CENP-B plays a dual role in centromere formation, ensuring de novo formation on DNA lacking a functional centromere but preventing the formation of excess centromeres on chromosomes.
Building the centromere: from foundation proteins to 3D organization.
Choo et al., Melbourne, Australia. In Trends Cell Biol, 2004
The sixth protein, CENP-B, although not essential in higher eukaryotes, has homologues in fission yeast that bind pericentric DNA and are essential for heterochromatin formation.
The role of CENP-B and alpha-satellite DNA: de novo assembly and epigenetic maintenance of human centromeres.
Ohzeki et al., Bethesda, United States. In Chromosome Res, 2003
The importance of alphoid DNA and CENP-B binding sites (CENP-B boxes), typical of normal human centromere DNA configurations, has been demonstrated through their requirement in de novo centromere assembly and Human Artificial Chromosome (HAC) assays.
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