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Chromodomain protein, Y-like

CDYL, CDYL1, chromodomain protein, Y-like, CDY-like
Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, G9a, CAN, CDY1, V1a
Papers on CDYL
Coordinated regulation of dendrite arborization by epigenetic factors CDYL and EZH2.
Liang et al., Beijing, China. In J Neurosci, 2014
Here, using gain- and loss-of-function approaches, we defined the chromodomain protein and transcription corepressor chromodomain Y-like (CDYL) protein as a negative regulator of dendrite morphogenesis in rat/mouse hippocampal neurons both in vitro and in vivo.
Cdyl, a new partner of the inactive X chromosome and potential reader of H3K27me3 and H3K9me2.
Heard et al., Paris, France. In Mol Cell Biol, 2013
Here we identify Cdyl, a chromodomain-containing transcriptional corepressor, as a new chromatin-associated protein partner of the inactive X chromosome (Xi).
Molecular determinants of cancer cell sensitivity and resistance towards the sesquiterpene farnesol.
Efferth et al., Mainz, Germany. In Pharmazie, 2013
Among the candidates were genes involved in apoptosis (STAB2, NUMBL), regulation of transcription (CDYL, FOXA2) and diverse other functional groups (INE1, CTRL, MRS2, NEB, LMO7, C9orf3, EHBP1).
Short-Form CDYLb but not long-form CDYLa functions cooperatively with histone methyltransferase G9a in hepatocellular carcinomas.
Yu et al., Changchun, China. In Genes Chromosomes Cancer, 2013
Recently, G9a was reported to form a complex with the H3K9 methylation effector protein CDYL, but little is known about the expression of CDYL in HCC patients.
Generation and neuronal differentiation of induced pluripotent stem cells in Cdyl-/- mice.
Li et al., Guangzhou, China. In Neuroreport, 2013
Chromodomain on Y-like (CDYL) is a chromodomain protein that has sequence homology to members of the enoyl CoA hydratase family.
Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27.
Liang et al., Beijing, China. In J Biol Chem, 2012
CDYL functions as a molecular bridge between PRC2 and the repressive chromatin mark H3K27me3, forming a positive feedback loop to facilitate the establishment and propagation of H3K27me3 modifications along the chromatin
H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing.
Lorincz et al., Vancouver, Canada. In Epigenetics Chromatin, 2010
Furthermore, using novel ERV reporter constructs targeted to a specific genomic site, we demonstrate that, relative to Setdb1, knockdown of the remaining known H3K9me3 readers expressed in mESCs, including Cdyl, Cdyl2, Cbx2, Cbx7, Mpp8, Uhrf1 and Jarid1a-c, leads to only modest proviral reactivation.
Homing of transplanted bone marrow cells in livers of Schistosoma mansoni-infected mice.
El Fandy et al., Al Jīzah, Egypt. In Apmis, 2010
Tracing of male donor-derived cells in female recipient mice livers was carried out by the detection of Y chromosome expression by fluorescent in situ hybridization (FISH) and also of chromodomain Y-linked (CDYL) protein by indirect immunofluorescence (IF).
Identification of non-histone substrates for JMJD2A-C histone demethylases.
Mukherji et al., Kansas City, United States. In Biochem Biophys Res Commun, 2010
A candidate substrate-based approach demonstrated that in addition to its known substrate, trimethylated histone H3-lysine-9, JMJD2A-C demethylate trimethylated lysine containing peptides from WIZ, CDYL1, CSB and G9a proteins, all constituents of transcription repression complexes.
Multimerization and H3K9me3 binding are required for CDYL1b heterochromatin association.
Fischle et al., Göttingen, Germany. In J Biol Chem, 2010
Results imply that multimeric binding to H3K9me3 by CDYL1b homomeric complexes is essential for efficient chromatin targeting.
CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.
Shi et al., Boston, United States. In Mol Cell, 2009
Chromodomain on Y-like (CDYL) is identified as a REST corepressor that physically bridges REST and the histone methylase G9a to repress transcription.
Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs.
Khorasanizadeh et al., Charlottesville, United States. In J Biol Chem, 2008
The human genome encodes three CDY family proteins, CDY, CDYL, and CDYL2.
Protein lysine methyltransferase G9a acts on non-histone targets.
Jeltsch et al., Bremen, Germany. In Nat Chem Biol, 2008
Using the specificity profile, we identified new non-histone protein targets of G9a, including CDYL1, WIZ, ACINUS and G9a (automethylation), as well as peptides derived from CSB.
Molecular characterization of the bovine chromodomain Y-like genes.
Liu et al., Reno, United States. In Anim Genet, 2008
bCDYL mapped by radiation hybrid mapping to bovine chromosome (BTA) 24, transcripts were found mainly in spermatids
Cdyl: a new transcriptional co-repressor.
Khochbin et al., Grenoble, France. In Embo Rep, 2003
Cdyl may participate in the global chromatin remodelling that occurs in spermatogenesis.
Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome.
Page et al., Cambridge, United States. In Nat Genet, 1999
The CDY genes have been localized to the human Y chromosome, and we report here that they are derivatives of a conventional single-copy gene, CDYL (CDY-like), located on human chromosome 13 and mouse chromosome 6.
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