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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Caudal type homeobox 2

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: CD20, Cdx1, HAD, CK7, CAN
Papers using CDX2 antibodies
The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine.
El-Rifai Wael, In PLoS ONE, 2007
... Generation of K14-Cdx2 transgenic mice ...
Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium
Lai Maode et al., In Molecular Cancer, 2006
... The monoclonal antibody of carcinoembryonic antigen (CEA) and polyclonal antibody of caudal-related homeodomain transcription 2 (CDX2) were purchased from Cell Signaling (Danvers, MA, USA) ...
Characterization of connexin31.1-deficient mice reveals impaired placental development
Asashima Makoto et al., In In Vitro Cellular & Developmental Biology. Animal, 2006
... The primary antibodies used are as follows: anti-Cdx2 antibody (Biogenex, San Ramon, CA; 1:100), ...
Perturbation of the tight junction permeability barrier by occludin loop peptides activates beta-catenin/TCF/LEF-mediated transcription.
Andre Frederic, In PLoS ONE, 2000
... Anti-Cdx1 and Cdx2 polyclonal antibodies were from cell signaling (Cell Signaling Technology, Inc ...
Papers on CDX2
The utility of CDX2, GATA3, and DOG1 in the diagnosis of testicular neoplasms: an immunohistochemical study of 109 cases.
Idrees et al., Indianapolis, United States. In Hum Pathol, Feb 2016
We identified 109 testicular tumors, including pure and mixed germ cell tumors and sex cord-stromal tumors, and conducted immunohistochemical staining for CDX2, DOG1, and GATA3 to address the potential utility of these readily available and commonly used markers in the evaluation of testicular tumors.
CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer.
Clarke et al., Ramat Gan, Israel. In N Engl J Med, Feb 2016
Results The transcription factor CDX2 ranked first in our screening test.
Immunohistochemistry of ductal adenocarcinoma of the prostate and adenocarcinomas of non-prostatic origin: a comparative study.
Egevad et al., Stockholm, Sweden. In Apmis, Feb 2016
Slides were stained for estrogen, progesterone and androgen receptor, prolactin, PSA, prostein, PSMA, PSAP, CDX2, lysozyme, villin, monoclonal CEA, CK7, CK20, HMWCK, p63, p504s, c-Myc, EGFR, Ki-67, p16, p21, p27, p53, PTEN, ERG, and PAX-8.
Sulfasalazine, a therapeutic agent for ulcerative colitis, inhibits the growth of CD44v9(+) cancer stem cells in ulcerative colitis-related cancer.
Kitagawa et al., Tokyo, Japan. In Clin Res Hepatol Gastroenterol, Feb 2016
In vitro assay revealed that sulfasalazine promoted the expression of epithelial differentiation markers (E-cadherin and CDX2) and inhibited the proliferation of CD44(+) cancer cells.
Intraductal Papillary Mucinous Neoplasms Often Contain Epithelium From Multiple Subtypes and/or Are Unclassifiable.
Longacre et al., Stanford, United States. In Am J Surg Pathol, Jan 2016
Immunohistochemistry for CDX2, MUC2, and MUC5AC was performed on cases where the histologic subtype could not be determined on routine hematoxylin and eosin (H&E) sections.
Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.
Greber et al., Münster, Germany. In Cell Stem Cell, Jan 2016
We found that WNT inhibition serves to restrict expression of anti-cardiac regulators MSX1 and CDX2/1.
Small Cell Carcinoma of the Urinary Bladder: KIT and PDGFRA Gene Mutations.
Kozacioğlu et al., İzmir, Turkey. In Rare Tumors, Jan 2016
The tumor cells were negative for CK7, CK20, CD3, CD20, LCA, CDX2, uroplakin, thyroid transcription factor 1, PSA and p63.
Expression profile of FGF receptors in preimplantation ovine embryos and the effect of FGF2 and PD173074.
Nasr-Esfahani et al., Eşfahān, Iran. In Growth Factors, Oct 2015
Assessment of expression profiles of lineage-associated markers revealed that FGF2 (500 ng/ml) supplementation: (i) significantly increased expression of putative hypoblast marker (GATA4), (ii) significantly decreased expression of putative epiblast (EPI) marker (NANOG) and (iii) did not change TE markers (CDX2 and IFNT) and pluripotency makers (OCT4, SOX2 and REX1).
Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype.
Yasui et al., Hiroshima, Japan. In Cancer Sci, Aug 2015
Ectopic CDX2 expression plays a key function in the GC intestinal phenotype.
Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy.
Sang et al., Nanjing, China. In An Bras Dermatol, May 2015
They were stained positive for villin, CDX-2, CKpan (AE1/ AE3), CEA, CK8/18, CK19, CK7, EMA, Ki-67 (50%), and negative for S-100, CK20, CD34, GCDFP-15 and TTF-1.
Metastatic carcinoma of unknown primary: diagnostic approach using immunohistochemistry.
Hornick et al., Boston, United States. In Adv Anat Pathol, May 2015
This review discusses the approach to the diagnosis of CUP using immunohistochemistry and outlines some of the most useful markers with a particular focus on the utility of lineage-restricted transcription factors, including CDX2, NKX3-1, PAX8, SATB2, TTF-1, and SF1.
Rectal mucosal endometriosis primarily misinterpreted as adenocarcinoma: a case report and review of literature.
Jiang et al., Guangzhou, China. In Int J Clin Exp Pathol, 2014
CK20 and CDX2 highlighted residual glands.
NANOG and CDX2 pattern distinct subtypes of human mesoderm during exit from pluripotency.
Pedersen et al., Cambridge, United Kingdom. In Cell Stem Cell, 2014
The mechanism of these cell fate decisions involved mutual repression of NANOG and CDX2.
Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of vater.
Biankin et al., Sydney, Australia. In J Clin Oncol, 2013
PATIENTS AND METHODS: We assessed the potential clinical utility of histomolecular phenotypes defined using a combination of histopathology and protein expression (CDX2 and MUC1) in 208 patients from three independent cohorts who underwent surgical resection for adenocarcinoma of the ampulla of Vater.
Transcriptional networks driving enhancer function in the CFTR gene.
Harris et al., Chicago, United States. In Biochem J, 2012
Data suggest that CDX2 is critical for maintenance of high levels of CFTR (cystic fibrosis transmembrane conductance regulator) expression in enterocytes; data also suggest that CFTR expression is controlled by multiple cis-regulatory factors.
Histomorphologic and molecular features of pouch and peripouch adenocarcinoma: a comparison with ulcerative colitis-associated adenocarcinoma.
Liu et al., Cleveland, United States. In Am J Surg Pathol, 2012
Pouch/peripouch and UC-associated adenocarcinoma had a comparable positive rate for CK7, CK20, and CDX2 by immunohistochemistry.
Delay of polarization event increases the number of Cdx2-positive blastomeres in mouse embryo.
Szczepanska et al., Warsaw, Poland. In Dev Biol, 2012
Results suggest that the main factor responsible for upregulation of Cdx2 expression in outer blastomeres is their polarity.
Expression and significance of homeodomain protein Cdx2 in gastric carcinoma and precancerous lesions.
Wang et al., Hefei, China. In World J Gastroenterol, 2012
Cdx2 is useful for predicting the prognosis of gastric carcinoma.
siRNA targeting of Cdx2 inhibits growth of human gastric cancer MGC-803 cells.
Xiao et al., Nanning, China. In World J Gastroenterol, 2012
Cdx2 was involved in regulating pro-gression of human gastric cancer cells MGC-803.
BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages.
Pedersen et al., Cambridge, United Kingdom. In Cell Stem Cell, 2011
BRA was necessary for and preceded CDX2 expression.
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