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CDP-diacylglycerol synthase

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CdS, PI3K, ACID, CAN, HAD
Papers on CDS2
Distinct properties of the two isoforms of CDP-diacylglycerol synthase.
Epand et al., Hamilton, Canada. In Biochemistry, 2015
Here we show in vitro that the two isoforms of human CDS, CDS1 and CDS2, show different acyl chain specificities for its lipid substrate.
The genetic basis of plasmid tropism between Chlamydia trachomatis and Chlamydia muridarum.
Clarke et al., Southampton, United Kingdom. In Pathog Dis, 2014
The differences between the pSW2 and pNigg allowed identification of the recombination breakpoints and showed that pGFP::SW2 had exchanged a ~ 1 kbp region with pNigg covering CDS 2. The recombinant plasmid (pSW2NiggCDS2) is maintained under antibiotic selection when transformed into plasmid-cured C. muridarum.
Extraplastidial cytidinediphosphate diacylglycerol synthase activity is required for vegetative development in Arabidopsis thaliana.
Frentzen et al., Aachen, Germany. In Plant J, 2013
Here we have focused on the extraplastidial CDS isoforms, encoded by CDS1 and CDS2 which are constitutively expressed contrary to CDS3.
MMAPPR: mutation mapping analysis pipeline for pooled RNA-seq.
Yost et al., Salt Lake City, United States. In Genome Res, 2013
We tested MMAPPR on two known mutant lines in zebrafish, nkx2.5 and tbx1, and used it to map two novel ENU-induced cardiovascular mutants, with mutations found in the ctr9 and cds2 genes.
The identification of novel targets of miR-16 and characterization of their biological functions in cancer cells.
Chen et al., Tianjin, China. In Mol Cancer, 2012
Furthermore, we experimentally validated three of these candidates, MAP7 (microtubule-associated protein 7), PRDM4 (PR domain containing 4) and CDS2 (CDP-diacylglycerol synthase 2), as direct targets of miR-16.
CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis.
Weinstein et al., Bethesda, United States. In Blood, 2012
Loss of CDS2, 1 of 2 vertebrate CDS enzymes, results in vascular-specific defects in zebrafish in vivo and failure of VEGFA-induced angiogenesis in endothelial cells in vitro.
Underexpression of miR-224 in methotrexate resistant human colon cancer cells.
Ciudad et al., Barcelona, Spain. In Biochem Pharmacol, 2012
Among them CDS2, DCP2, HSPC159, MYST3 and SLC4A4 were validated at the mRNA level by qRT-PCR.
Regular and problematic leisure-time Internet use in the community: results from a German population-based survey.
Müller et al., Mainz, Germany. In Cyberpsychol Behav Soc Netw, 2011
In a representative survey of the German population, we queried 1,401 women and 1,111 men between the ages of 14 and 94 years by specific questions and standardized questionnaires on depression, anxiety (HADS), and depersonalization (CDS-2).
Base rates for depersonalization according to the 2-item version of the Cambridge Depersonalization Scale (CDS-2) and its associations with depression/anxiety in the general population.
Beutel et al., Mainz, Germany. In J Affect Disord, 2011
BACKGROUND: Recently, the two item version of the Cambridge Depersonalization Scale (CDS-2) has been validated in a clinical sample and has demonstrated that it is a useful tool for the detection of clinically significant depersonalization (DP).
Two closely related genes of Arabidopsis encode plastidial cytidinediphosphate diacylglycerol synthases essential for photoautotrophic growth.
Frentzen et al., Aachen, Germany. In Plant Physiol, 2010
Alternative translation initiation or alternative splicing of CDS2 and CDS4 transcripts can result in up to 10 isoforms.
[Screening for depersonalization-derealization with two items of the cambridge depersonalization scale].
Beutel et al., Mainz, Germany. In Psychother Psychosom Med Psychol, 2010
This short version (CDS-2) was tested in a sample of 38 patients with clinical significant DP-DR and 49 patients without or only mild DP-DR.
Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control.
Kang et al., Taipei, Taiwan. In Neoplasia, 2010
Disruption of cardiolipin biosynthesis by phosphatidylglycero-phosphate synthase (PGS) or CDP-diacylglycerol synthase 2 (CDS-2) short hairpin RNA (shRNA) transfection eliminated the MMC-induced translocation of mitochondrial p53.
Regulation of cardiolipin biosynthesis by fatty acid transport protein-1 IN HEK 293 cells.
Hatch et al., Winnipeg, Canada. In Biochim Biophys Acta, 2009
[1,3-(3)H]Glycerol uptake was unaltered whereas activity of cytidine-5'-diphosphate-1,2-diacyl-sn-glycerol synthetase (CDS) and CDS-2 mRNA expression were reduced in FATP-1 expressing cells compared to control.
Abscisic acid has a key role in modulating diverse plant-pathogen interactions.
Lamb et al., Norwich, United Kingdom. In Plant Physiol, 2009
We isolated an activation-tagged Arabidopsis (Arabidopsis thaliana) line, constitutive disease susceptibility2-1D (cds2-1D), that showed enhanced bacterial growth when challenged with various Pseudomonas syringae strains.
Caudal dysplasia syndrome and sirenomelia: are they part of a spectrum?
Azouz et al., Miami, United States. In Fetal Pediatr Pathol, 2008
Of 9 children with CDS 2 (22.2%) had bilateral renal agenesis versus 66% of sirenomelics.
Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.
Platzer et al., Jena, Germany. In Genome Biol, 2006
the apparent occurrence of an unusual TG 3' splice site in intron 8 is discussed
Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2.
Halford et al., London, United Kingdom. In Gene, 2005
Cds2 showed a ubiquitous pattern of expression and was mapped to chromosome 2G1.
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