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Cyclin-dependent kinase 2

CDK2, Cyclin-Dependent Kinase 2
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, p21, CDK4, p27, V1a
Papers using CDK2 antibodies
Combination chemotherapy of nafamostat mesilate with gemcitabine for pancreatic cancer targeting NF-kappaB activation.
Chandra Dhyan, In PLoS ONE, 2008
... Antibodies against p21, Cdk4 (mouse monoclonal), p27, cyclin D1, cyclin E, Cdk2 (rabbit polyclonal), and horseradish peroxidase-conjugated secondary antibodies were procured from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infections.
Bresnahan Wade, In PLoS Pathogens, 2005
... aphidicolin (Sigma-Aldrich, final concentration: 5 µg/ml), hydroxyurea (Sigma-Aldrich, 1 mM), roscovitine (Millipore-Calbiochem, 5–50 µM), CVT313 (purchased as CDK2 inhibitor III from Millipore-Calbiochem, 10–50 µM), SU9516 (Santa Cruz Biotechnology, Santa Cruz, CA, USA, ...
Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events.
Lichterfeld Mathias, In PLoS ONE, 2002
... total JNK, CDK4, cyclin D2, cyclin D1, CDK6 and CDK2 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA).
Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
Harbour J. William et al., In Oncogene, 1999
... Louis, MO, USA), p38 inhibitor (SB 203580, Millipore, Billerica, MA, USA), Cdk2 inhibitor (Roscovitine, Sigma Aldrich), Cdk4 inhibitor (EMD, Darmstadt, ...
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
Gallyas Ferenc, In PLoS ONE, 1997
... CDK2 (sc-163, Santa Cruz Biotechnology, INC), PKAc(C-20, Santa Cruz ...
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Papers on CDK2
A two kinase-gene signature model using CDK2 and PAK4 expression predicts poor outcome in non-small cell lung cancers.
Bao et al., In Neoplasma, Feb 2016
In this study, with publicly available microarray data of non-small cell lung cancers (NSCLC), we identified two kinase genes cyclin-dependent kinase 2 (CDK2) and p21 protein (Cdc42/Rac)-activated kinase 4 (PAK4) significantly associated with poor outcome.
Phosphorylated retinoblastoma protein is a potential predictive marker of irinotecan efficacy for colorectal cancer.
Sakai et al., Kyoto, Japan. In Int J Oncol, Feb 2016
Intriguingly, the knockdown of both CDK4 and CDK6, but not CDK2, allowed RB to become the most hypophosphorylated form and converted the SN38-sensitive cells to a resistant state.
Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin α2/β5/FAK signaling pathway.
Cheng et al., Shanghai, China. In Oncotarget, Feb 2016
Here, we show that Bufalin can inhibit cervical cancer cell proliferation, block cell cycle in G2/M phase, induce cellular apoptosis and reduce cell metastasis through stimulation of p21waf/cip1, p27cip/kip, Bax and E-cadherin, and suppression of cyclin A, cyclin B1, CDK2, Bcl-2, Bcl-xl, MMP9 and SNAIL1.
Axon guidance molecule Semaphorin3A is a novel tumor suppressor in head and neck squamous cell carcinoma.
Song et al., Nanjing, China. In Oncotarget, Feb 2016
Both genetic and recombinant SEMA3A protein inhibited cell proliferation and colony formation and induced apoptosis, accompanied by decreased cyclin E, cyclin D, CDK2, CDK4 and CDK6 and increased P21, P27, activated caspase-5 and caspase-7.
Cyclin-dependent kinase-mediated phosphorylation of breast cancer metastasis suppressor 1 (BRMS1) affects cell migration.
Šarčević et al., Australia. In Cell Cycle, Feb 2016
In the present study, we show that BRMS1 is a novel substrate of Cyclin-Dependent Kinase 2 (CDK2) that is phosphorylated on serine 237 (S237).
Overexpression of Cell Cycle Proteins of Peripheral Lymphocytes in Patients with Alzheimer's Disease.
Kim et al., Seoul, South Korea. In Psychiatry Investig, Jan 2016
The cell cycle proteins CDK2, CDK4, CDK6, cyclin B, and cyclin D were measured in peripheral lymphocytes.
Linker histones in hormonal gene regulation.
Beato et al., Spain. In Biochim Biophys Acta, Nov 2015
A complex sequence of enzymatic events, including phosphorylation by CDK2, PARylation by PARP1 and the ATP-dependent activity of NURF, are required for H1 displacement and gene de-repression, as a prerequisite for further nucleosome remodeling.
Roscovitine in cancer and other diseases.
Valius et al., Genève, Switzerland. In Ann Transl Med, Jun 2015
It is a broad-range purine inhibitor, which inhibits CDK1, CDK2, CDK5 and CDK7, but is a poor inhibitor for CDK4 and CDK6.
The history and future of targeting cyclin-dependent kinases in cancer therapy.
Knudsen et al., Dallas, United States. In Nat Rev Drug Discov, Feb 2015
Moreover, perturbations in chromosomal stability and aspects of S phase and G2/M control mediated by CDK2 and CDK1 are pivotal tumorigenic events.
Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2.
Wang et al., Dalian, China. In Int J Mol Sci, 2014
Cyclin-dependent kinase 2 (CDK2) is a crucial regulator of the eukaryotic cell cycle.
EBV-driven B-cell lymphoproliferative disorders: from biology, classification and differential diagnosis to clinical management.
Young et al., Houston, United States. In Exp Mol Med, 2014
LMP-1 also induces BCL-2 to escape from apoptosis and gives a signal for cell cycle progression by enhancing cyclin-dependent kinase 2 and phosphorylation of retinoblastoma (Rb) protein and by inhibiting p16 and p27.
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
O'Neill et al., Oxford, United Kingdom. In Nat Cell Biol, 2014
CDK2 phosphorylates BRCA2 (pS3291-BRCA2) to limit stabilizing contacts with polymerized RAD51; however, how replication stress modulates CDK2 activity and whether loss of pS3291-BRCA2 regulation results in genomic instability of tumours are not known.
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
Wei et al., Boston, United States. In Nature, 2014
Mechanistically, phosphorylation of S477 and T479 at the Akt extreme carboxy terminus by cyclin-dependent kinase 2 (Cdk2)/cyclin A or mTORC2, under distinct physiological conditions, promotes Akt activation through facilitating, or functionally compensating for, S473 phosphorylation.
The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit.
Meyer et al., Stanford, United States. In Cell, 2013
Here, we introduce a live-cell sensor for CDK2 activity and unexpectedly found that proliferating cells bifurcate into two populations as they exit mitosis.
Inhibition of human cytomegalovirus immediate-early gene expression by cyclin A2-dependent kinase activity.
Wiebusch et al., Berlin, Germany. In J Virol, 2012
Human cytomegalovirus IE1/2 expression was downregulated by cyclin A2, CDK1 and CDK2.
The CDK subunit CKS2 counteracts CKS1 to control cyclin A/CDK2 activity in maintaining replicative fidelity and neurodevelopment.
Yu et al., London, United Kingdom. In Dev Cell, 2012
resulting unrestricted cyclin A/CDK2 activity is accompanied by shortening of the cell cycle, increased replication fork velocity, and DNA damage
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.
Fisher et al., New York City, United States. In Plos Genet, 2012
By a chemical-genetic approach study identified Nbs1 as a target of Cdk2, and mapped the phosphorylation to a conserved CDK consensus recognition site.
Overexpression of cyclin E/CDK2 complexes overcomes FGF-induced cell cycle arrest in the presence of hypophosphorylated Rb proteins.
Basilico et al., New York City, United States. In Cell Cycle, 2012
Overexpressed cyclin E/CDK2 molecules were stably associated with p107 and p130 in FGF-treated cells in the context of E2F repressive complexes.
Successive phosphorylation of p27(KIP1) protein at serine-10 and C terminus crucially controls its potency to inactivate Cdk2.
Okayama et al., Tokyo, Japan. In J Biol Chem, 2012
phosphorylation of p27(KIP1) protein at serine-10 and C terminus crucially controls its potency to inactivate Cdk2
Control of Drosophila endocycles by E2F and CRL4(CDT2).
Edgar et al., Heidelberg, Germany. In Nature, 2012
DNA replication in endocycling Drosophila cells is triggered by cyclin E/cyclin dependent kinase 2 (CYCE/CDK2), but this kinase must be inactivated during each G-phase to allow the assembly of pre-Replication Complexes (preRCs) for the next S-phase.
More papers using CDK2 antibodies
Cyclin D1 triggers autonomous growth of breast cancer cells by governing cell cycle exit
Black Jennifer D. et al., In The Journal of Cell Biology, 1995
... –cyclin D (pan), –cyclin E, -pRb, -p107, -p130, -PKCδ, and -PKCε, and polyclonal goat anti-p15 and -cdk2 antibodies were obtained from Santa Cruz Biotechnology, Inc ...
R: a language for data analysis and graphics.
Durbin Richard et al., In Genome Biology, 1995
... ] by parsing the webpage CDK, CDK1, or CDK2 to obtain uniprot IDs and then looking these ...
P27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21
Iwamori Masao et al., In International Journal of Molecular Sciences, 1993
... The anti-Cyclin E and CDK2 were purchased from Epitomics (USA) ...
Quantitation of pyrimidine dimers by immunoslot blot following sublethal UV-irradiation of human cells.
Bielinsky Anja-Katrin, In PLoS ONE, 1986
... Rabbit phospho-p53 (Ser15) and phospho-Cdk2 (Thr160) antibodies were from Cell Signaling Technology (Danvers, MA) ...
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