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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cadherin 13, H-cadherin

CDH13, T-cadherin, H-cadherin, T-cad
This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: p16, E-cadherin, adiponectin, APC, CAN
Papers on CDH13
Environmental correlation analysis for genes associated with protection against malaria.
MalariaGEN Consortium et al., Kilifi, Kenya. In Mol Biol Evol, Feb 2016
By contrast, two of the random SNPs that had highly significant correlations (P < 0.01) were in genes previously linked to malaria resistance, namely, CDH13, encoding cadherin 13, and HS3ST3B1, encoding heparan sulphate 3-O-sulfotransferase 3B1.
Polygenic associations of neurodevelopmental genes in suicide attempt.
Wasserman et al., Stockholm, Sweden. In Mol Psychiatry, Jan 2016
Among the 590 SA polygenes implicated here, there were several developmentally important functions (cell adhesion/migration, small GTPase and receptor tyrosine kinase signaling), and 16 of the SA polygenes have previously been studied in SB (BDNF, CDH10, CDH12, CDH13, CDH9, CREB1, DLK1, DLK2, EFEMP1, FOXN3, IL2, LSAMP, NCAM1, nerve growth factor (NGF), NTRK2 and TBC1D1).
Adiponectin downregulation is associated with volume overload-induced myocyte dysfunction in rats.
Zhong et al., Auburn, United States. In Acta Pharmacol Sin, Dec 2015
The protein expression of adiponectin, adiponectin receptors (AdipoR1/R2 and T-cadherin) and AMPK activity were measured using Western blot analyses.
Guidance Receptors in the Nervous and Cardiovascular Systems.
Tkachuk et al., Moscow, Russia. In Biochemistry (mosc), Oct 2015
Apart from these receptors and their ligands, urokinase and its receptor (uPAR) and T-cadherin are also classified as guidance molecules.
Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation.
Xu et al., Hong Kong, Hong Kong. In Cell Metab, Sep 2015
Mechanistically, adiponectin was recruited to the cell surface of M2 macrophages via its binding partner T-cadherin and promoted the cell proliferation by activation of Akt, consequently leading to beige cell activation.
Differential Associations between CDH13 Genotypes, Adiponectin Levels, and Circulating Levels of Cellular Adhesive Molecules.
Ko et al., Taipei, Taiwan. In Mediators Inflamm, 2014
CDH13 gene variants with lower adiponectin levels are paradoxically associated with a more favorable metabolic profile.
Adiponectin in asthma: implications for phenotyping.
Bianco et al., Napoli, Italy. In Curr Protein Pept Sci, 2014
Recently, different studies demonstrated the involvement of adiponectin in asthma since its levels and the expression of AdipoR1, AdipoR2 and T-cadherin are modulated in asthma patients and in asthma mouse models.
Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis.
Black et al., Atlanta, United States. In Plos One, 2014
Chlamydia induced EMT in vitro and in vivo, marked by the suppression of normal epithelial cell markers especially E-cadherin but up-regulation of mesenchymal markers of pathological EMT, including T-cadherin, MMP9, and fibronectin.
Adiponectin signaling in the liver.
Marliss et al., Chapel Hill, United States. In Rev Endocr Metab Disord, 2014
This article reviews the adiponectin signaling pathway in the liver through T-cadherin, AdipoR1, AdipoR2, AMPK, ceramidase activity, APPL1 and the recently discovered Suppressor Of Glucose from Autophagy (SOGA).
Cardiometabolic effects of adiponectin.
Walsh et al., Boston, United States. In Best Pract Res Clin Endocrinol Metab, 2014
T-cadherin, a GPI-anchored adiponectin-binding protein, was recently identified as critical for the cardiac-protective and revascularization actions of adiponectin.
Adiponectin: a manifold therapeutic target for metabolic syndrome, diabetes, and coronary disease?
Tenenbaum et al., Tel Aviv-Yafo, Israel. In Cardiovasc Diabetol, 2013
T-cadherin, a membrane-associated adiponectin-binding protein lacking intracellular domain seems to be a main mediator of the antiatherogenic adiponectin actions.
Direct identification of ligand-receptor interactions on living cells and tissues.
Wollscheid et al., Zürich, Switzerland. In Nat Biotechnol, 2012
Using TRICEPS to label intact mature vaccinia viruses, we identified the cell surface proteins AXL, M6PR, DAG1, CSPG4 and CDH13 as binding factors on human cells.
T-Cadherin is an auxiliary negative regulator of EGFR pathway activity in cutaneous squamous cell carcinoma: impact on cell motility.
Resink et al., Basel, Switzerland. In J Invest Dermatol, 2012
It was shown that the main consequence of T-cad silencing in squamous cell carcinoma is facilitation of ligand-dependent EGFR activation. T-cadherin modulates the EGFR pathway activity by influencing membrane compartmentalization of EGFR.
VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex.
Bergers et al., San Francisco, United States. In Cancer Cell, 2012
Consequently, VEGF blockade restores and increases MET activity in GBM cells in a hypoxia-independent manner, while inducing a program reminiscent of epithelial-to-mesenchymal transition highlighted by a T-cadherin to N-cadherin switch and enhanced mesenchymal features.
Decreased expression of T-cadherin is associated with gastric cancer prognosis.
Huo et al., Changsha, China. In Hepatogastroenterology, 2012
HER-2/neu and TOPIIa are over expressed in gastric tumors and may promote disease progression.
T-cadherin attenuates insulin-dependent signalling, eNOS activation, and angiogenesis in vascular endothelial cells.
Resink et al., Basel, Switzerland. In Cardiovasc Res, 2012
T-cad expression modulates signalling and functional responses of the vascular endothelium to insulin.
CDH13 gene coding T-cadherin influences variations in plasma adiponectin levels in the Japanese population.
Morisaki et al., Ōsaka, Japan. In Hum Mutat, 2012
Identification of a strong statistically associated SNP (rs4783244) with adiponectin levels in the first intron of CDH13 (T-cadherin) gene in a 30-kb haplotype block covering the promoter region to first intron.
[Aberrant methylation of T-cadherin gene in human esophageal carcinoma cells].
Wu et al., Wenzhou, China. In Zhonghua Yi Xue Za Zhi, 2011
Aberrant methylation in promoter region is an important mechanism of T-cadherin gene inactivation in esophageal carcinoma cells. 5-Aza-CdR can increase expression of T-cadherin by a reversal of hypermethylation and inhibit cell proliferation and invasion.
DNA methylation markers and early recurrence in stage I lung cancer.
Herman et al., Baltimore, United States. In N Engl J Med, 2008
Methylation of the promoter region of CDH13 in patients with stage I NSCLC treated with curative intent by means of surgery is associated with early recurrence.
Multiple loci identified in a genome-wide association study of prostate cancer.
Chanock et al., Bethesda, United States. In Nat Genet, 2008
Susceptibility genes CPNE3, IL16 and CDH13 with moderate effects associated with susceptibility to prostate cancer.
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