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CUB domain containing protein 1

CDCP1, Trask, CUB domain-containing protein 1
The protein encoded by this gene is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Src, CD45, CAN, V1a, HAD
Papers on CDCP1
Aminopeptidase N (APN/CD13) as a target molecule for scirrhous gastric cancer.
Kajiyama et al., Tokyo, Japan. In Clin Res Hepatol Gastroenterol, Feb 2016
These analyses showed that the scirrhous gastric cancer cell lines HSC-58 and HSC-44PE heterogeneously expressed CD13, while CD44, CDCP1, EpCAM and ABCG2 were expressed uniformly.
Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer.
Semmes et al., Norfolk, United States. In Oncotarget, Jan 2016
CUB-domain-containing protein 1 (CDCP1) is a trans-membrane protein regulator of cell adhesion with a potent pro-migratory function in tumors.
The effects of age and gender on plasma levels of 63 cytokines.
Kamali-Moghaddam et al., Uppsala, Sweden. In J Immunol Methods, Oct 2015
and 15 of the biomarkers (CCL11, CCL25, CDCP1, CSF-1, CXCL11, CXCL9, FGF-23, Flt3L, HGF, IL-10RB, MCP-3, MCP-4, MMP-10, OPG, VEGF-A) were significantly associated with age.
HIF-2α regulates CDCP1 to promote PKCδ-mediated migration in hepatocellular carcinoma.
Zhang et al., Tianjin, China. In Tumour Biol, Sep 2015
UNASSIGNED: Overexpression of CUB domain-containing protein 1 (CDCP1), a transmembrane glycoprotein and major substrate of Src family kinases (SFKs), always indicates unfavorable outcomes in various cancers.
The role of CDCP1 (CUB domain-containing protein 1) and ADAM12 (a disintegrin and metalloproteinase 12) in ovarian cancer.
Achimas-Cadariu et al., Cluj-Napoca / Kolozsvár, Romania. In J Buon, May 2015
In this view, recent research has been able to highlight promising candidates such as CDCP1 and ADAM12.
Interaction of CDCP1 with HER2 enhances HER2-driven tumorigenesis and promotes trastuzumab resistance in breast cancer.
Alimonti et al., Bellinzona, Switzerland. In Cell Rep, May 2015
Here, we show that CDCP1 and HER2 are frequently co-overexpressed in metastatic breast tumors and associated with poor patient prognosis.
Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance.
Hooper et al., Australia. In Oncogene, May 2015
We demonstrate that the transmembrane glycoprotein CUB-domain-containing protein 1 (CDCP1) has important and inhibitable roles in these processes.
The tyrosine phosphatase SHP2 associates with CUB domain-containing protein-1 (CDCP1), regulating its expression at the cell surface in a phosphorylation-dependent manner.
Gesbert et al., Orsay, France. In Plos One, 2014
CUB domain-containing protein-1 (CDCP1) is a transmembrane glycoprotein that is phosphorylated by SRC family kinases (SFK) before recruiting and activating PKCδ.
ADAM9 enhances CDCP1 protein expression by suppressing miR-218 for lung tumor metastasis.
Sher et al., Taiwan. In Sci Rep, 2014
We previously demonstrated that ADAM9 enhanced the expression of the pro-migratory protein CDCP1 to promote lung metastasis; however, the regulatory process remains unknown.
Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling.
Minter et al., Gaithersburg, United States. In Mol Cancer, 2014
An anti-CUB domain containing protein 1 (CDCP1) antibody was tested for tumour growth inhibition in a patient-derived xenograft model, generated from a stage-IV non-small cell lung carcinoma, with and without cisplatin.
Predicting resistance by selection of signaling pathways.
Viteri et al., Barcelona, Spain. In Transl Lung Cancer Res, 2014
Furthermore, stromal hepatocyte growth factor (HGF) confers EGFR tyrosine kinase inhibitor (TKI) resistance and induces interreceptor crosstalk with integrin-b4, Eph2, CUB domain-containing protein-1 (CDCP1), AXL and JAK1.
Proteomic analysis of microvesicles released by the human prostate cancer cell line PC-3.
Llorente et al., Oslo, Norway. In Mol Cell Proteomics, 2012
Secreted CDCP1 can be a useful genetic marker for the diagnosis of metastatic prostate cancer.
The cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migration.
Hooper et al., Australia. In J Biol Chem, 2012
a novel role for CDCP1 in EGF/EGFR-induced cell migration and indicate that targeting of CDCP1 may be a rational approach to inhibit progression of cancers driven by EGFR signaling
The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility.
Soltoff et al., Boston, United States. In Oncogene, 2012
Data show that the signaling events that accompany the CDCP1 tyrosine phosphorylation observed in cell lines and lung tumors may explain how the CDCP1/SFK complex regulates motility and adhesion.
Cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734.
Hooper et al., South Brisbane, Australia. In J Biol Chem, 2012
analysis of cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734
Roles of CUB domain-containing protein 1 signaling in cancer invasion and metastasis.
Sakai et al., Tokyo, Japan. In Cancer Sci, 2011
CUB domain-containing protein 1 (CDCP1) is a substrate of Src family kinases and has been shown to regulate anoikis resistance, migration and matrix degradation during tumor invasion and metastasis in a tyrosine phosphorylation-dependent manner. Review.
The cell surface glycoprotein CDCP1 in cancer--insights, opportunities, and challenges.
Hooper et al., Australia. In Iubmb Life, 2009
In the last few years dysregulated expression of the cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) has been associated with several cancers and this cell surface molecule has been recognized both as a tumor marker and as a potential target to disrupt progression of cancer.
The C2 domain of PKCdelta is a phosphotyrosine binding domain.
Soltoff et al., Boston, United States. In Cell, 2005
We provide evidence that this domain mediates PKCdelta interaction with a Src binding glycoprotein, CDCP1.
Vomeronasal Receptors and Signal Transduction in the Vomeronasal Organ of Mammals
Tirindelli et al., Boca Raton, United States. In Unknown Journal, 0001
In Didelphimorphia, Lagomorpha, and Rodentia, the VNO chemosensory epithelium presents two separate neuronal layers (apical and basal) characterized by the expression of different G protein subunits and receptors (Young & Trask 2007).
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