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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

3'-phosphoadenosine 5'-phosphosulfate synthase 1

Cdc7, SK1, SKI
Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, ACID, HAD, Src
Papers using Cdc7 antibodies
Human foamy virus capsid formation requires an interaction domain in the N terminus of Gag
Young John A. T, In PLoS Pathogens, 2000
... The cells were then labeled with FITC-anti-CD8 (clone SK1; BD Biosciences,,
Papers on Cdc7
From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-chlorophenyl)thiazol-2-ylamino)phenol (SKI-II).
Flynn et al., In J Med Chem, Feb 2016
UNASSIGNED: The sphingosine kinase (SK) inhibitor, SKI-II, has been employed extensively in biological investigations of the role of SK1 and SK2 in disease and has demonstrated impressive anticancer activity in vitro and in vivo.
Deletion of Mbtps1 (PCSK8, S1P, SKI-1) in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age.
Brotto et al., Kansas City, United States. In J Biol Chem, Jan 2016
UNASSIGNED: Conditional deletion of Mbtps1 (cKO) protease in bone osteocytes leads to an age-related increase in mass (12%) and in contractile force (30%) in adult slow twitch soleus muscles (SOL) with no effect on fast twitch extensor digitorum longus muscles (EDL).
Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma.
Kuo et al., Kao-hsiung, Taiwan. In J Agric Food Chem, Jan 2016
We also reveal that curcumin suppressed phthalate-induced migration, invasion, and CSC-like cell maintenance through inhibition of the aryl hydrocarbon receptor/ERK/SK1/S1P3 signaling pathway.
Mechanism of folding and activation of subtilisin kexin isozyme-1(SKI-1)/site-1 protease (S1P).
Kunz et al., Lausanne, Switzerland. In J Biol Chem, Jan 2016
UNASSIGNED: The proprotein convertase subtilisin kexin isozyme-1(SKI-1)/site-1 protease (S1P) is implicated in lipid homeostasis, the unfolded protein response, and lysosome biogenesis.
Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering anti-viral responses.
Carr et al., Adelaide, Australia. In J Gen Virol, Dec 2015
UNASSIGNED: Sphingosine kinase (SK) 1 is a host kinase that enhances some viral infections.
Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation.
Pyne et al., Bologna, Italy. In Adv Biol Regul, Oct 2015
UNASSIGNED: Sphingosine kinase (there are two isoforms, SK1 and SK2) catalyses the formation of sphingosine 1-phosphate (S1P), a bioactive lipid that can be released from cells to activate a family of G protein-coupled receptors, termed S1P1-5.
1p36 deletion syndrome: an update.
Scott et al., Houston, United States. In Appl Clin Genet, 2014
In particular, we highlight evidence implicating MMP23B, GABRD, SKI, PRDM16, KCNAB2, RERE, UBE4B, CASZ1, PDPN, SPEN, ECE1, HSPG2, and LUZP1 in various 1p36 deletion phenotypes.
Sphingosine kinase 1 as an anticancer therapeutic target.
Zhao et al., Xi'an, China. In Drug Des Devel Ther, 2014
Elevated sphingosine kinase 1 (SK1) levels is predictive of a poor prognosis, and SK1 overexpression may confer resistance to chemotherapeutics.
An Updated Review on the Genetics of Primary Open Angle Glaucoma.
Chalam et al., Riyadh, Saudi Arabia. In Int J Mol Sci, 2014
Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) at different loci including CAV1/CAV2, TMCO1, CDKN2B-AS1, CDC7-TGFBR3, SIX1/SIX6, GAS7 and ATOH7 to be associated with POAG and its related quantitative traits (endophenotypes).
Human Mendelian diseases related to abnormalities of the RNA exosome or its cofactors.
Badens et al., Marseille, France. In Intractable Rare Dis Res, 2014
SD/THE is caused by a defect of the SKI complex (TTC37 and SKIV2L), the cytoplasmic co-factor of the RNA exosome for mRNA degradation.
A new player SETs in myeloid malignancy.
Aifantis et al., In Nat Genet, 2013
The identified mutations frequently target the SKI-homologous domain, although the exact pathogenic mechanisms remain unknown.
Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm.
Dietz et al., Baltimore, United States. In Nat Genet, 2012
We identified causative variation in ten individuals with SGS in the proto-oncogene SKI, a known repressor of TGF-β activity.
Role of small conductance calcium-activated potassium channels expressed in PVN in regulating sympathetic nerve activity and arterial blood pressure in rats.
Chen et al., Nantong, China. In Am J Physiol Regul Integr Comp Physiol, 2012
Small conductance Ca(2+)-activated K(+) (SK) channels expressed in the hypothalamic paraventricular nucleus play an important role in the regulation of sympathetic outflow and cardiovascular function.
Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers.
Li et al., Shanghai, China. In Cancer Sci, 2012
study showed expression patterns of SULT1E1 and PAPSS in breast and endometrial tissues; the estrogen sulfation enzymes were comparatively higher in the tumorous tissues than adjacent normal tissues; overexpression of SULT1E1 and PAPSS1 retarded MCF-7 cells growth in vivo and in vitro by arresting cell cycles and inducing apoptosis
The biology and therapeutic targeting of the proprotein convertases.
Prat et al., Montréal, Canada. In Nat Rev Drug Discov, 2012
Seven of these (proprotein convertase 1 (PC1), PC2, furin, PC4, PC5, paired basic amino acid cleaving enzyme 4 (PACE4) and PC7) activate cellular and pathogenic precursor proteins by cleavage at single or paired basic residues, whereas subtilisin kexin isozyme 1 (SKI-1) and proprotein convertase subtilisin kexin 9 (PCSK9) regulate cholesterol and/or lipid homeostasis via cleavage at non-basic residues or through induced degradation of receptors.
Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation.
Huang et al., Los Angeles, United States. In J Biol Chem, 2012
A mutant SKI defective in transformation fails to increase p53 ubiquitination and is unable to increase MDM2 levels and to increase mono-sumoylation of Ubc9
Mechanism of cancer cell death induced by depletion of an essential replication regulator.
Masai et al., Tokyo, Japan. In Plos One, 2011
cell death process induced by Cdc7 depletion
Sphingosine kinase 1 deficiency exacerbates LPS-induced neuroinflammation.
Wadgaonkar et al., New York City, United States. In Plos One, 2011
results suggest that SphK1 activation is involved in the regulation of LPS induced brain injury
Dbf4-dependent CDC7 kinase links DNA replication to the segregation of homologous chromosomes in meiosis I.
Zachariae et al., Dresden, Germany. In Cell, 2008
Dbf4-dependent Cdc7 kinase (DDK) regulates monopolin localization together with the polo-kinase Cdc5 bound to Spo13, probably through phosphorylation of the monopolin subunit Lrs4
Hsk1-Dfp1 is required for heterochromatin-mediated cohesion at centromeres.
Forsburg et al., Los Angeles, United States. In Nat Cell Biol, 2003
Here we demonstrate that Schizosaccharomyces pombe Hsk1 (CDC7), a conserved Dbf4-dependent protein kinase (DDK) that regulates replication initiation, interacts with and phosphorylates the heterochromatin protein 1 (HP1) equivalent Swi6 (ref.
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