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F-box and WD repeat domain containing 7

Cdc4, Argonaute, Ago1, Fbw7, FBXW7
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: CAN, Dicer, V1a, miR, Ubiquitin
Papers using Cdc4 antibodies
Distribution of a glycosylphosphatidylinositol-anchored protein at the apical surface of MDCK cells examined at a resolution of < 100 A using imaging fluorescence resonance energy transfer
Carrington James, In PLoS Biology, 1997
... 2 coding sequences from pMyc-Ago1 and pMyc-Ago2 followed by cloning into the XbaI and EcoRI sites of pEYFP-C1 and pECFP-C1 (BD Biosciences, Palo Alto, California, United ...
Papers on Cdc4
Dicer1 mediated miRNA processing shapes the mRNA profile and function of murine platelets.
Weyrich et al., Salt Lake City, United States. In Blood, Feb 2016
Argonaute 2 (Ago2), a member of the miRNA silencing complex, co-immunoprecipitated with αIIb and β3 mRNAs in wild-type platelets.
Ubiquitin ligase Fbw7 restricts the replication of hepatitis C virus by targeting NS5B for ubiquitination and degradation.
Guo et al., Wuhan, China. In Biochem Biophys Res Commun, Feb 2016
The well known tumor suppressor Fbw7, a component of E3 ubiquitin ligase SCF(Fbw7), targets oncoproteins or cellular regulatory proteins for ubiquitin-mediated degradation through a highly conserved binding site called a Cdc4 phosphodegron (CPD).
FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4.
Sun et al., Ann Arbor, United States. In Mol Cell, Feb 2016
UNASSIGNED: FBXW7 is a haploinsufficient tumor suppressor with loss-of-function mutations occurring in human cancers.
Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction.
Zou et al., Ann Arbor, United States. In Nat Immunol, Jan 2016
EZH2 activated the Notch pathway by suppressing Notch repressors Numb and Fbxw7 via trimethylation of histone H3 at Lys27 and, consequently, stimulated T cell polyfunctional cytokine expression and promoted their survival via Bcl-2 signaling.
tRFs: miRNAs in disguise.
Tsutsumi et al., Mangalore, India. In Gene, Jan 2016
Moreover, we have reviewed the association of tRFs with Argonaute proteins, including their potential to function as miRNAs.
Pediatric-Like Acute Lymphoblastic Leukemia Therapy in Adults With Lymphoblastic Lymphoma: The GRAALL-LYSA LL03 Study.
Dombret et al., Marseille, France. In J Clin Oncol, Jan 2016
Multivariate analysis identified serum lactate dehydrogenase level and the NOTCH1/FBXW7/RAS/PTEN oncogene (a four-gene oncogenetic classifier) status but not positron emission tomography or hematopoietic stem cell transplant as independent prognostic factors for outcome in T-LL.
The expanding world of small RNAs in plants.
Martienssen et al., New York City, United States. In Nat Rev Mol Cell Biol, Dec 2015
We also discuss the diversification of small-RNA-directed silencing pathways through the expansion of RNA-dependent RNA polymerases, DICER proteins and ARGONAUTE proteins.
The piRNA Pathway Guards the Germline Genome Against Transposable Elements.
Webster et al., Pasadena, United States. In Adv Exp Med Biol, Dec 2015
At the core of the piRNA pathway is a ribonucleoprotein complex consisting of a small RNA, called piRNA, and a protein from the PIWI subfamily of Argonaute nucleases.
Piwi-interacting RNAs in cancer: emerging functions and clinical utility.
Martinez et al., Vancouver, Canada. In Mol Cancer, Dec 2015
In contrast to microRNAs, piRNAs interact with PIWI proteins, another member of the Argonaute family, and function primarily in the nucleus.
Genetic Signature of Resistance to White Band Disease in the Caribbean Staghorn Coral Acropora cervicornis.
Vollmer et al., United States. In Plos One, Dec 2015
Genes involved in RNA interference-mediated gene silencing, including Argonaute were up-regulated in resistant corals, whereas heat shock proteins (HSPs) were down-regulated.
A transgenerational role of the germline nuclear RNAi pathway in repressing heat stress-induced transcriptional activation in C. elegans.
Gu et al., United States. In Epigenetics Chromatin, Dec 2015
RESULTS: We performed 12-generation temperature-shift experiments using the wild-type C. elegans and a mutant strain that lacks the germline-specific nuclear Argonaute protein HRDE-1/WAGO-9.
[Alternative Splicing Detection as a Biomarker for Cancer Diagnosis: A Novel Progressive Mechanism of Acute Lymphoblastic Leukemia with Alternative Splicing as a Biomarker Candidate].
Nomura et al., In Rinsho Byori, Sep 2015
Finally, we will discuss our hypothesis that FIRΔexon2 interferes with FBW7, that FIRΔexon2 inhibits PP1 in the EGFR pathway, and that FIR haploinsufficiency is potentially associated with protein expression through transcriptional and post-transcriptional mechanisms.
Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides.
Serebrov et al., Worcester, United States. In Cell, Aug 2015
Argonaute proteins repress gene expression and defend against foreign nucleic acids using short RNAs or DNAs to specify the correct target RNA or DNA sequence.
A Dynamic Search Process Underlies MicroRNA Targeting.
Joo et al., Delft, Netherlands. In Cell, Aug 2015
Here, we used single-molecule FRET to directly visualize how human Argonaute-2 (Ago2) searches for and identifies target sites in RNAs complementary to its miRNA guide.
Current topics of functional links between primary cilia and cell cycle.
Inagaki et al., Nagoya, Japan. In Cilia, 2014
In the elongation step, Nde1, a negative regulator of ciliary length, is revealed to be ubiquitylated and degraded by CDK5-SCF(Fbw7) in a cell cycle-dependent manner.
Evaluation of Fbxw7 expression and its correlation with expression of SREBP-1 in a mouse model of NAFLD.
Liu et al., Xi'an, China. In Mol Med Report, 2012
Fbxw7 was decreased in NAFLD and negatively correlated with SREBP-1, indicating that the Fbxw7-SREBP-1 axis may play a key pathological role in the development of NAFLD.
Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.
Krensky et al., Bethesda, United States. In Blood, 2012
Fbw7 gamma - mediated ubiquitination of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.
The microRNA pathway genes AGO1, HEN1 and HYL1 participate in leaf proximal-distal, venation and stomatal patterning in Arabidopsis.
Ponce et al., Alacant, Spain. In Plant Cell Physiol, 2012
AGO1, HYL1, and HEN1 function in proximal-distal and vascular patterning of leaves.
Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase.
Lu et al., Boston, United States. In Mol Cell, 2012
overexpressing Pin1 reduces Fbw7 abundance and suppresses Fbw7's ability to inhibit proliferation and transformation
Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway.
Sangfelt et al., Stockholm, Sweden. In Nat Commun, 2011
Fbw7-mediated destruction of p100 is a regulatory component restricting the response to NF-kappaB2 pathway stimulation.
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