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Cell division cycle 25 homolog A

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, cdc25, CDK2, CAN, Chk1
Papers using Cdc25A antibodies
Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process.
Blagosklonny Mikhail V., In PLoS ONE, 2002
... Cdc25A cDNA was inserted into pIREShyg2 vector (Clontech Laboratories, Palo Alto, CA) ...
Papers on Cdc25A
Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway.
Wang et al., Guangzhou, China. In Cancer Med, Jan 2016
The activation of CHK1/CDC25A/CDK2 pathway was also demonstrated in Mus81-inhibited HepG2 cells and xenograft mouse tumors under EPI treatment.
Gene expression profiling of lung adenocarcinoma in Xuanwei, China.
Zhang et al., Kunming, China. In Eur J Cancer Prev, Jan 2016
The tendency of changes in the expression of 12 selected DEGs (five downregulated genes, PIK3R1, RARB, HGF, MAPK11, and SESN1, and seven upregulated genes, PAK1, E2F1, CCNE1, EGF, CDC25A, PTTG1, and UHRF1) in RTq-PCR was consistent with the expression profiling data.
Identification of key genes in hepatocellular carcinoma and validation of the candidate gene, cdc25a, using gene set enrichment analysis, meta‑analysis and cross‑species comparison.
Cao et al., Nanning, China. In Mol Med Report, Jan 2016
Reverse transcription‑quantitative polymerase chain reaction and western blotting were performed to determine the mRNA and protein expression levels of cdc25a, one of the identified candidate genes, in human, rat and tree shrew samples.
Focused library with a core structure extracted from natural products and modified: application to phosphatase inhibitors and several biochemical findings.
Sodeoka et al., Wako, Japan. In Acc Chem Res, Jun 2015
The resulting compounds showed dramatically improved cell membrane permeability and inhibitory selectivity and included VHR (vaccinia VH1-related)-selective RE12 and CDC25A/B (cell division cycle 25A/B)-selective RE44.
De novo resistance biomarkers to anti-HER2 therapies in HER2-positive breast cancer.
Calleja-Hernández et al., Granada, Spain. In Pharmacogenomics, 2014
Biomarkers like p95HER2, CCND1 and CDC25A have demonstrated clinical relevance and prognostic value in HER2-positive BC patients.
Downregulation of cell cycle-related proteins in ovarian cancer line and cell cycle arrest induced by microRNA.
Ling et al., Yongchuan, China. In Int J Clin Exp Med, 2014
miR-449b caused the expression of CDK6 and CDC25A to decrease.
miRNA signature identification of retinoblastoma and the correlations between differentially expressed miRNAs during retinoblastoma progression.
Mei et al., Wuhan, China. In Mol Vis, 2014
In addition, hsa-miR-25, hsa-miR-18a, and hsa-miR-20a shared the common target BCL2L11; hsa-let-7b and hsa-miR-125b targeted the genes CDC25A, CDK6, and LIN28A.
Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia--the possibility to target several kinases through inhibition of the various CDC25 isoforms.
Bruserud et al., Bergen, Norway. In Molecules, 2013
The cell division cycle 25 (CDC25) phosphatases include CDC25A, CDC25B and CDC25C.
Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity.
Dong et al., Changsha, China. In Carcinogenesis, 2012
Moreover, the regulatory effect of miRNA in radiosensitivity can be enhanced when interacting with various key molecules, including H2AX, BRCA1, ATM, DNA-PK, RAD51, Chk1, Cdc25A, p53, PLK1, HIF-1 and VEGF, which are involved in these processes.
Rock2 regulates Cdc25A through ubiquitin proteasome system in hepatocellular carcinoma cells.
Shao et al., Nanchang, China. In Exp Cell Res, 2012
A new role for Rock2 in modulation of Cdc25A ubiquitination has been revealed, indicating a novel mechanism of Cdc25A regulation and a potential function for Rock2 in the development of hepatocellular carcinoma.
Accelerated elimination of ultraviolet-induced DNA damage through apoptosis in CDC25A-deficient skin.
Hansen et al., Omaha, United States. In Carcinogenesis, 2012
deletion of Cdc25a increased apoptosis and accelerated the elimination of DNA damage following UV
The role of Cdc25A in the regulation of cell proliferation and apoptosis.
Huang et al., Shreveport, United States. In Anticancer Agents Med Chem, 2012
Cell division cycle 25 A (Cdc25A), a dual-specificity protein phosphatase, is one of the most crucial cell cycle regulators, which removes the inhibitory phosphorylation in cyclin-dependent kinases (CDKs), such as CDK2, CDK4, and CDK6, and positively regulates the activities of CDKs that lead to cell cycle progression.
Oocytes progress beyond prophase in the presence of DNA damage.
Carroll et al., London, United Kingdom. In Curr Biol, 2012
In the DNA damage response, instead of inhibiting cyclin B-CDK1 through destruction of Cdc25A phosphatase, oocytes utilize an inhibitory phosphorylation of Cdc25B.
Lin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer.
Zhang et al., Philadelphia, United States. In J Biol Chem, 2012
Lin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer.
Cdc25A promotes cell survival by stimulating NF-κB activity through IκB-α phosphorylation and destabilization.
Kim et al., Ch'unch'ŏn, South Korea. In Biochem Biophys Res Commun, 2012
Cdc25A has an important physiological role in NF-kappaB activity regulation and it may be an important survival mechanism of cancer cells.
High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A.
Aaronson et al., New York City, United States. In Cancer Cell, 2011
High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/beta-catenin target gene, CDC25A.
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.
Dixit et al., San Francisco, United States. In Nat Cell Biol, 2010
As a major regulator of Cdc25A, Dub3 is an example of a transforming ubiquitin hydrolase that subverts a key component of the cell cycle machinery, promoting oncogenic transformation.
Cdc25A and Dub3 in a high-stakes balancing act.
Harper et al., Boston, United States. In Nat Cell Biol, 2010
The deubiquitylating enzyme Dub3 is found to have oncogenic potential by stabilizing the Cdc25A protein phosphatase, a crucial regulator of cell-cycle progression.
Inhibitors of Cdc25 phosphatases as anticancer agents: a patent review.
Novellino et al., Napoli, Italy. In Expert Opin Ther Pat, 2010
IMPORTANCE OF THE FIELD: The cell division cycle 25 (Cdc25) family of proteins are highly conserved dual specificity phosphatases that regulate cyclin-dependent kinases, the main gatekeepers of the eukaryotic cell division cycle.
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.
Helin et al., Milano, Italy. In Nat Cell Biol, 2009
A key target of the checkpoints is the CDC25A (cell division cycle 25 homologue A) phosphatase, which is essential for the activation of cyclin-dependent kinases and cell-cycle progression.
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