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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cell division cycle 25 homolog C

cdc25, Cdc25C, p190, phosphotyrosine phosphatase, ras-GRF1
This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CDC2, p53, V1a, CAN
Papers using cdc25 antibodies
Role of myeloid cells in vascular endothelial growth factor-independent tumor angiogenesis.
Thi Thu Nguyen Hang, In PLoS ONE, 2009
... Control antibodies for flow cytometric analysis were: PE-conjugated rat IgG (Emfret/P190-2), FITC-conjugated rat IgG (Emfret/P190-1), rabbit IgG (Cedarlane/CLRB00) and FITC-conjugated rat IgM ...
Influence of zinc deficiency on Akt-Mdm2-p53 and Akt-p21 signaling axes in normal and malignant human prostate cells.
El-Rifai Wael, In PLoS ONE, 2008
... (SC-509), Rb (SC-50), p21 (SC-817), p27 (SC-528), E2F1 (SC-193), CDK1 (SC-8395), Cyclin B1 (SC-595), and CDC25C (SC-13138) antibodies, together with all secondary antibodies (anti-mouse, anti-goat and anti-rabbit immunoglobulin G) were purchased from Santa Cruz Biotechnology, Inc ...
Adipocytes impair leukemia treatment in mice
Heisterkamp Nora et al., In Oncoimmunology, 2008
... Growth of B2 and 8093 mouse Bcr/Abl P190 transgenic pro-/pre-B acute lymphoblastic leukemia ...
Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis
Pollack Jonathan R. et al., In Oncogene, 2004
... Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice ...
Regulation of the G2/M transition by p53
Adrian Thomas E et al., In Molecular Cancer, 2000
... The monoclonal mouse cyclin A, B, cdc25A, and GAPDH antibodies, and the polyclonal rabbit cdc25C antibody were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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Papers on cdc25
Redundant Regulation of Cdk1 Tyrosine Dephosphorylation in Saccharomyces cerevisiae.
Rudner et al., Ottawa, Canada. In Genetics, Jan 2016
The kinase Wee1, and the phosphatase Cdc25, regulate the mitotic activity of Cdk1 by the reversible phosphorylation of a conserved tyrosine residue.
Kaempferol activates G2-checkpoint of the cell cycle resulting in G2-arrest and mitochondria-dependent apoptosis in human acute leukemia Jurkat T cells.
Kim et al., Taegu, South Korea. In J Microbiol Biotechnol, Jan 2016
Exposure of J/Neo cells to kaempeferol caused cytotoxicity, activation of ATM/ATR-Chk1/Chk2 pathway, activating phosphorylation of p53 (Ser-15), inhibitory phosphorylation of Cdc25C (Ser-216), and inactivation of cyclin-dependent kinase 1 (Cdk1), and resultant G2-arrest of the cell cycle.
Multiple functions of the Eya phosphotyrosine phosphatase.
Rebay, Chicago, United States. In Mol Cell Biol, Jan 2016
UNASSIGNED: Eyes absent (Eya), a protein conserved from plants to humans, and best characterized as a transcriptional coactivator, is also the prototype for a novel class of eukaryotic aspartyl protein tyrosine phosphatases.
Coexistence of p190 BCR/ABL Transcript and CALR 52-bp Deletion in Chronic Myeloid Leukemia Blast Crisis: A Case Report.
Saki et al., Ahvāz, Iran. In Mediterr J Hematol Infect Dis, Dec 2015
To our knowledge, this is the first case of a patient initially diagnosed as p190 BCR-ABL transcript positive CML in blast crisis characterized by a 52-bp deletion in CALR gene.
Exon-centric regulation of ATM expression is population-dependent and amenable to antisense modification by pseudoexon targeting.
Vorechovsky et al., Southampton, United Kingdom. In Sci Rep, Dec 2015
The U2AF-regulated exon usage in the ATM signalling pathway was centred on the MRN/ATM-CHEK2-CDC25-cdc2/cyclin-B axis and preferentially involved transcripts implicated in cancer-associated gene fusions and chromosomal translocations.
Rare but authentic Philadelphia-positive acute myeloblastic leukemia: two case reports and a literature review of characteristics, treatment and outcome.
Reman et al., Caen, France. In Hematol Oncol Stem Cell Ther, Mar 2015
One patient had a complex karyotype including 7 monosomy (-7) and p190 BCR-ABL fusion transcript.
Cell cycle and cell fate in the developing nervous system: the role of CDC25B phosphatase.
Pituello et al., Toulouse, France. In Cell Tissue Res, 2015
Here, we summarize recent data describing how cell cycle dynamics affect the switch between proliferation and differentiation, with an emphasis on the roles played by the cell cycle regulators, the CDC25 phosphatases.
Mefloquine inhibits chondrocytic proliferation by arresting cell cycle in G2/M phase.
Dong et al., Shanghai, China. In Int J Clin Exp Pathol, 2014
Western blot analysis was used to examine the expression levels of cyclin B1/cdc2, cdc25c, p21WAF1/CIP1 and p53.
Protein tyrosine phosphatases as potential therapeutic targets.
Zhang et al., Indianapolis, United States. In Acta Pharmacol Sin, 2014
This review summarizes recent findings on several highly recognized PTP family drug targets, including PTP1B, Src homology phosphotyrosyl phosphatase 2(SHP2), lymphoid-specific tyrosine phosphatase (LYP), CD45, Fas associated phosphatase-1 (FAP-1), striatal enriched tyrosine phosphatases (STEP), mitogen-activated protein kinase/dual-specificity phosphatase 1 (MKP-1), phosphatases of regenerating liver-1 (PRL), low molecular weight PTPs (LMWPTP), and CDC25.
Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia--the possibility to target several kinases through inhibition of the various CDC25 isoforms.
Bruserud et al., Bergen, Norway. In Molecules, 2013
The cell division cycle 25 (CDC25) phosphatases include CDC25A, CDC25B and CDC25C.
ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres.
Tarsounas et al., Oxford, United Kingdom. In Embo J, 2012
Dysfunctional telomeres promote ATM/ATR-dependent degradation of CDC25C phosphatase to block mitotic entry, thereby preventing telomere dysfunction-driven genomic instability.
Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens.
Yap et al., Brisbane, Australia. In Nat Cell Biol, 2012
Centralspindlin also inhibits the junctional localization of p190 B RhoGAP, which can inactivate Rho.
Transient neonatal diabetes mellitus gene Zac1 impairs insulin secretion in mice through Rasgrf1.
Spengler et al., München, Germany. In Mol Cell Biol, 2012
identified the guanine nucleotide exchange factor Rasgrf1 as a direct Zac1/Plagl1 target gene in beta cells
Protection of CDC25 phosphatases against oxidative stress in breast cancer cells: evaluation of the implication of the thioredoxin system.
Bagrel et al., Metz, France. In Free Radic Res, 2012
data suggest that the maintenance of CDC25 activity does not fully rely on the thioredoxin reductase system in breast cancer cells, even in the presence of a major oxidative stress
Embryonic onset of late replication requires Cdc25 down-regulation.
O'Farrell et al., San Francisco, United States. In Genes Dev, 2012
findings suggest that high Cdc25 and Cdk1 contribute to the speed of the rapid, pre-midblastula transition (MBT) S phases and that down-regulation of these activities plays a broader role in MBT-associated changes than was previously suspected
[Prokaryotic expression and purification of human GST-Cdc25C fusion protein and preliminary detection of its function].
Du et al., Beijing, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012
cloning and functional analysis of Cdc25C
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts.
Alitalo et al., Helsinki, Finland. In Nat Cell Biol, 2008
In contrast, in contacting cells Ang1 induced Tie2 translocation to cell-cell contacts and the formation of homotypic Tie2-Tie2 trans-associated complexes that included the vascular endothelial phosphotyrosine phosphatase, leading to inhibition of paracellular permeability.
CDC25 phosphatases in cancer cells: key players? Good targets?
Ducommun et al., Toulouse, France. In Nat Rev Cancer, 2007
Cell division cycle 25 (CDC25) phosphatases regulate key transitions between cell cycle phases during normal cell division, and in the event of DNA damage they are key targets of the checkpoint machinery that ensures genetic stability.
Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition.
Kuang et al., Houston, United States. In Cell, 2007
In A2780 cells, ERK1/2 interacts with Cdc25C in interphase and phosphorylates Cdc25C in mitosis. Inhibition of ERK activation partially inhibits T48 phosphorylation, Cdc25C activation, and mitotic induction.
Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.
Croce et al., Columbus, United States. In Cancer Cell, 2007
In Lzts1(-/-) mouse embryo fibroblasts (MEFs), Cdc25C degradation was increased during M phase, resulting in decreased Cdk1 activity.
More papers using cdc25 antibodies
p190RhoGAP is the convergence point of adhesion signals from α5β1 integrin and syndecan-4
Humphries Martin J. et al., In The Journal of Cell Biology, 1999
... transferrin receptor (Invitrogen); a rat monoclonal antibody against TCP-1α (Assay Designs); and a rabbit polyclonal antibody against p190-B (Cell Signaling Technology) were used according ...
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
Park Hye-Jin et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1990
... Anti-Cdc25c (Cell Signaling Technology Inc., Danvers, MA), ...
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
Belkhiri Abbes, In PLoS ONE, 1989
... Akt, p-Akt and β-actin were purchased from Cell Signaling Technology (Beverly, MA); Cyclin B1, Cdc25B, Cdc25c, Ki-67, and the secondary antibodies, which were horseradishperoxidase-conjugated, were purchased from Santa Cruz Biotechnology, Inc ...
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