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Cdc10 MBF transcription factor complex subunit Cdc10

cdc10, SEPT7, Cdc10p
This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: CAN, SEP2, Swi6, Actin, ACID
Papers on cdc10
Roles of septins in prospore membrane morphogenesis and spore wall assembly in S. cerevisiae.
McMurray et al., Denver, United States. In Mol Biol Cell, Jan 2016
Strikingly, extra copies of septin CDC10 rescue sporulation and LEP localization in cells lacking Sma1, a phospholipase d-associated protein dispensable for initiation of PSM assembly and PSM curvature but required for PSM extension.
Fission Yeast Cell Cycle Synchronization Methods.
Moreno et al., Salamanca, Spain. In Methods Mol Biol, Dec 2015
The most widely used approaches are cdc10-129 for G1; hydroxyurea (HU) for early S-phase; cdc25-22 for G2, and nda3-KM311 for mitosis.
Association of the expression levels in the longissimus muscle and a SNP in the CDC10 gene with marbling in Japanese Black beef cattle.
Yamada et al., Hohhot, China. In Meat Sci, Oct 2015
The septin 7 (CDC10) gene, involved in cellular proliferation, has been previously shown to be expressed at different levels in the longissimus muscle (LM) between low-marbled and high-marbled steer groups by differential-display PCR.
Sep(t)arate or not – how some cells take septin-independent routes through cytokinesis.
Gaestel et al., Hannover, Germany. In J Cell Sci, Jun 2015
In this Commentary, we present recent observations that specific cell divisions can proceed in the absence of the core mammalian septin SEPT7 and its Drosophila homolog Peanut (Pnut) and that thus challenge the view that septins have an essential role in cytokinesis.
Association of the expression levels in the skeletal muscle and a SNP in the CDC10 gene with growth-related traits in Japanese Black beef cattle.
Yamada et al., Niigata, Japan. In Anim Genet, Apr 2015
The septin 7 (CDC10) gene, involved in cellular proliferation, is located within a genomic region of a quantitative trait locus for growth-related traits.
SW1PerS: Sliding windows and 1-persistence scoring; discovering periodicity in gene expression time series data.
Harer et al., Durham, United States. In Bmc Bioinformatics, 2014
These genes are BOP3, CDC10, YIL108W, YER034W, MLP1, PAC2 and RTT101.
[Affinity chromatography and proteomic screening as the effective method for S100A4 new protein targets discovery].
Koshelev, In Mol Biol (mosk), 2014
With the same' method we had identify some new S100A4 target proteins such as cytoskeleton proteins Sept2, Sept7, Sept11 and this interaction would can to highlight as S100A4 would regulate cell motility.
The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology.
Kotlyarov et al., Hannover, Germany. In Mol Cell Biol, 2012
performed large-scale interaction screens to understand the neuronal functions of the ERK3/MK5 pathway and identified septin7 (Sept7) as a novel interacting partner of ERK3
Localization of septin proteins in the mouse cochlea.
Ito et al., Kyoto, Japan. In Hear Res, 2012
Report SEPT4/5/7 expression in mouse cochlea and roles in auditory function.
Promiscuous interactions of human septins: the GTP binding domain of SEPT7 forms filaments within the crystal.
Garratt et al., São Carlos, Brazil. In Febs Lett, 2012
the purification, crystallization and structure for the GTP-binding domain of human septin 7
Septin9 is involved in septin filament formation and cellular stability.
Füchtbauer et al., Århus, Denmark. In Biol Chem, 2011
In Sept9 knockout cells, long septin filaments stained for Sept7 disappeared. Instead, staining was found in short, often curved filaments and rings. Furthermore, Sept7 was no longer localized to the mitotic spindle
Structural and biochemical properties of Sept7, a unique septin required for filament formation.
Wittinghofer et al., Dortmund, Germany. In Biol Chem, 2011
Sept7 occupies the ends of hexameric building blocks which assemble into non-polarised filaments.
Septin genomics: a road less travelled.
Hall et al., Belfast, United Kingdom. In Biol Chem, 2011
What was known as SEPT13 is now defined as one of many SEPT7 related pseudogenes.
Structural insight into filament formation by mammalian septins.
Wittinghofer et al., Dortmund, Germany. In Nature, 2007
crystal structures of the human SEPT2 G domain and the heterotrimeric human SEPT2-SEPT6-SEPT7 complex
Nuclear access and action of notch in vivo.
Adachi et al., New York City, United States. In Cell, 1998
In addition, our results suggest that signal transduction by Notch depends on the ability of the intracellular domain, particularly the portion containing the CDC10 repeats, to reach the nucleus and to participate in the transcriptional activation of downstream target genes.
Interaction between Wingless and Notch signaling pathways mediated by dishevelled.
Perrimon et al., Boston, United States. In Science, 1996
A direct physical interaction between Dishevelled and the Notch carboxyl terminus, distal to the cdc10/ankyrin repeats, suggests a mechanism for this interaction.
p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeast.
Nurse et al., London, United Kingdom. In Cell, 1995
The fission yeast gene cdc18 is required for DNA replication and is transcriptionally activated by the cdc10/res1/res2 control acting at START in late G1.
Analysis of phenotypic abnormalities and cell fate changes caused by dominant activated and dominant negative forms of the Notch receptor in Drosophila development.
Artavanis-Tsakonas et al., New Haven, United States. In C R Acad Sci Iii, 1993
The Notch protein contains a large extracellular domain of 36 EGF-like repeats as well as 3 Notch/lin-12 repeats and an intracellular domain with 6 cdc10/ankyrin repeats, motifs which are highly conserved in several vertebrate Notch homologues [1-7].
Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+.
Yanagida et al., Kyoto, Japan. In Cell, 1993
Mitosis and cytokinesis occur in the presence of hydroxyurea or in the double mutant cdc10-cut5 (the cdc10 mutation alone blocks progression from G1 to S). Gene cloning shows that cut5+ is identical to the fission yeast rad4+ gene, which is similar to human XRCC1.
Control over the onset of DNA synthesis in fission yeast.
Nurse et al., London, United Kingdom. In Philos Trans R Soc Lond B Biol Sci, 1988
Two gene functions cdc2 and cdc10 must be executed for the cell to traverse 'start' and proceed from G1 into S-phase.
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