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CD99 molecule

CD99, MIC2, D-4
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: vimentin, CD34, S-100, HAD, fibrillin-1
Papers using CD99 antibodies
A case of primary small cell carcinoma of the breast
Bergkvist Leif et al., In Pathology Research International, 2006
... c-erbB-2 oncoprotein (Dako, HER-2), mammoglobin (Dako, clone 304-1A5, 1 : 1), CD56 (Zymed Laboratories, clone 123C3, 1 : 100), CD99 (Dako, clone 12E7, 1 : 100), NSE ...
Approaches to augmenting the immunogenicity of melanoma gangliosides: from whole melanoma cells to ganglioside-KLH conjugate vaccines
de Dávila María Teresa G. et al., In Clinical and Developmental Immunology, 1994
... Carpinteria, CA, USA) raised to neuroblastoma cells, while cases of ESFT were examined using an anti-CD99 antibody (Dako Cytomation) ...
Papers on CD99
Localized signals that regulate transendothelial migration.
Muller, United States. In Curr Opin Immunol, Feb 2016
The adhesion molecules, PECAM (CD31) and CD99 that regulate two major steps in TEM, do so by regulating specific signals.
Utility of CD99 Paranuclear Expression in the Differential Diagnosis of Merkel Cell Carcinoma.
Lino-Silva et al., Mexico. In Int J Surg Pathol, Feb 2016
BACKGROUND: Recent reviews have referred to the paranuclear dot-like staining pattern of CD99 in several neoplasms, including solid pseudopapillary tumors in the pancreas, colonic adenocarcinomas, and colonic adenomas as well as in Merkel cell carcinoma (MCC).
Cutting Edge: CD99 Is a Novel Therapeutic Target for Control of T Cell-Mediated Central Nervous System Autoimmune Disease.
Muller et al., Chicago, United States. In J Immunol, Feb 2016
We report that CD99 is critical for lymphocyte transmigration without affecting adhesion in a human blood-brain barrier model.
Comparison of Primary Spinal Central and Peripheral Primitive Neuroectodermal Tumors in Clinical and Imaging Characteristics and Long-term Outcome.
Xu et al., Beijing, China. In World Neurosurg, Jan 2016
The diagnosis was cPNETs in 6 patients for negative CD99 expression and pPNETs in 19 patients for positive CD99 expression.
Solitary fibrous tumor of the breast: report of a case with emphasis on diagnostic role of STAT6 immunostaining.
Palazzo et al., Catania, Italy. In Pathol Res Pract, Jan 2016
The diagnosis was confirmed in the excised specimen, which exhibited a tumor with an immunohistochemical profile consistent with SFT, including diffuse expression of CD34, CD99 and bcl2.
Microcystic/Reticular Schwannoma of the Mandible First Case Report and Review of the Literature.
Wu et al., Shanghai, China. In Medicine (baltimore), Nov 2015
Tumor cells were also positive for CD34, CD99, and NSE, but negative for CK, EMA, CK5/6, P63, Calponin, CD10, SMA, Desmin, GFAP, NF, Syn, and CgA.
Synovial sarcoma of the heart: A case report and literature review.
Kannan et al., Chennai, India. In J Cancer Res Ther, Jul 2015
Immunohistochemistry was positive for S-100, B-cell lymphoma-2, MIC-2 and calretinin.
Infant pleuropulmonary blastoma: report of a rare case and review of literature.
Wang et al., Beijing, China. In Int J Clin Exp Pathol, 2014
Immunohistochemistry was performed for further detection: vimentin (+), S-100 protein (+), CK (AE1/AE3), EMA and TTF-1 in residual epithelial components (+), NSE (focal +), SMA (mesenchymal cells, focal +), CD99 (weak +), Bcl-2 (weak +), desmin (-), myoglobin (-), calretinin (-), calponin (-), FLI (-), MyoD-1 (-), and CD34 (-).
Ewing's sarcoma of the cervix, a diagnostic dilemma: a case report and review of the literature.
Yalamanchili et al., United States. In J Med Case Reports, 2014
However, additional positive immunostaining for CD99 was strongly suggestive of Ewing's sarcoma.
Primary sclerosing epithelioid fibrosarcoma of kidney with variant histomorphologic features: report of 2 cases and review of the literature.
Aki et al., Ankara, Turkey. In Diagn Pathol, 2014
They were negative for S-100 protein, CD34, and desmin, whereas CD99 were positive in one lesion.
Proteomics-based strategy to delineate the molecular mechanisms of RhoGDI2-induced metastasis and drug resistance in gastric cancer.
Yoo et al., Chinju, South Korea. In J Proteome Res, 2012
We delineate the mechanism by which RhoGDI2 promotes gastric cancer cell invasion and chemoresistance. In total, 47 differential protein spots were identified; 33 were upregulated, and 14 were downregulated by RhoGDI2 overexpression.
RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration.
Theodorescu et al., Charlottesville, United States. In J Clin Invest, 2012
RhoGDI2 suppresses lung metastasis in mouse models by reducing the expression of isoforms V1 and V3 of the proteoglycan versican. RhoGDI2 suppressed metastasis by altering inflammation in the tumor microenvironment.
The interrelationships between Src, Cav-1 and RhoGD12 in transitional cell carcinoma of the bladder.
Edwards et al., Glasgow, United Kingdom. In Br J Cancer, 2012
activation of the Src family members and downstream signalling proteins are associated with a good prognosis in transitional cell carcinoma of the bladder, and activated Src has a positive relationship with RhoGD12.
CD99-dependent expansion of myeloid-derived suppressor cells and attenuation of graft-versus-host disease.
Jung et al., Seoul, South Korea. In Mol Cells, 2012
CD99 plays a crucial role in the attenuation of graft-versus-host disease by regulating the expansion of myeloid-derived suppressor cells.
Association of D4-GDI expression with breast cancer progression.
Zhang et al., Bethesda, United States. In Cancer Biomark, 2010
Results suggest that D4-GDI may function as a biphasic regulator of breast cancer progression and metastasis.
The genome of the simian and human malaria parasite Plasmodium knowlesi.
Berriman et al., Sanger, United States. In Nature, 2008
One of these families, the KIRs, contains sequences that collectively match over one-half of the host CD99 extracellular domain, which may represent an unusual form of molecular mimicry.
CD99 plays a major role in the migration of monocytes through endothelial junctions.
Muller et al., New York City, United States. In Nat Immunol, 2002
CD99 is a heavily O-glycosylated 32-kD type I transmembrane protein that is expressed on most hematopoietic cells.
Mitomycin, ifosfamide, and cisplatin in unresectable non-small-cell lung cancer: effects on survival and quality of life.
Souhami et al., Birmingham, United Kingdom. In J Clin Oncol, 1999
We describe the two largest reported, randomized, parallel trials designed to determine whether the addition of chemotherapy influences duration and quality of life in localized, unresectable (mitomycin, ifosfamide, cisplatin [MIC]1 trial) and extensive (MIC2 trial) disease.
Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(p13;q12): desmoplastic small round-cell tumor and its variants.
Rosai et al., New York City, United States. In J Clin Oncol, 1998
Tumor cells were usually reactive with antibodies to keratin (67 of 78 cases, 86%), epithelial membrane antigen (50 of 54, 93%), vimentin (64 of 66, 97%), desmin (70 of 78, 90%), neuron-specific enolase (60 of 74, 81%), and the EWS-WT1 chimeric protein (25 of 27, 93%); typically nonreactive for muscle common actin (one of 58, 2%), myogenin (zero of eight, 0%), and chromogranin (one of 46, 2%); and variably reactive for MIC2 (nine of 47, 20%) and p53 (five of 17 with > 20% tumor cells reactive).
Cloning of PBDX, an MIC2-related gene that spans the pseudoautosomal boundary on chromosome Xp.
Weller et al., New York City, United States. In Nat Genet, 1994
The predicted amino acid sequence of the 540 bp coding region is 48% homologous to 12E7, the product of MIC2.
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