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CD81 molecule

CD81, TAPA-1
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Tetraspanin, CAN, CD45, CD63, HAD
Papers using CD81 antibodies
Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes
Mekada Eisuke et al., In The Journal of Cell Biology, 2001
... Rat anti–mouse CD9 mAb (KMC8) and anti-CD81 mAb (Eat1) were obtained from BD Biosciences.
Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane
Gould Stephen J. et al., In The Journal of Cell Biology, 1989
... anti–human CD81, phycoerythrin-conjugated anti–human CD81, and unlabeled monoclonal antibody directed against human CD30 (BerH8) and CD81 (JS-81) were obtained from BD Biosciences.
Papers on CD81
Targeting of Ly9 (CD229) Disrupts Marginal Zone and B1 B Cell Homeostasis and Antibody Responses.
Engel et al., Barcelona, Spain. In J Immunol, Feb 2016
In addition, Ly9 mAb dramatically diminished in vivo humoral responses and caused a selective downregulation of the CD19/CD21/CD81 complex on B cells and concomitantly an impaired B cell survival and activation in an Fc-independent manner.
Hepatitis C virus utilizes VLDLR as a novel entry pathway.
Shimotohno et al., Ichikawa, Japan. In Proc Natl Acad Sci U S A, Feb 2016
In addition to the factors previously reported, we discovered that the very-low-density lipoprotein receptor (VLDLR) mediates HCV entry independent of CD81.
Immunophenotype of normal vs. myeloma plasma cells: Toward antibody panel specifications for MRD detection in multiple myeloma.
Orfao et al., Salamanca, Spain. In Cytometry B Clin Cytom, Jan 2016
Among the later markers, CD19, CD45, CD27, and CD81, together with CD56, CD117, CD200, and CD307, have emerged as particularly informative; however, no single marker provides enough specificity for clear discrimination between clonal PCs and normal PCs.
Gene expression profiling of prostate cancer-associated genes identifies fibromodulin as potential novel biomarker for prostate cancer.
Reyes et al., Cartagena, Colombia. In Int J Biol Markers, Jan 2016
Genes evaluated were ESM-1, SERPINE2, CLU, BGN, A2M, PENK, FMOD, CD81, DCN, TSPAN8, KBTBD10, F2RL1, TMSB4X, SNCG, CXXC5, FOXQ1, PDPN, SPN, CAV1, CD24 and KLK3.
Preventive Role of Tetraspanin CD9 in Systemic Inflammation of Chronic Obstructive Pulmonary Disease.
Tachibana et al., Ōsaka, Japan. In Am J Respir Cell Mol Biol, Dec 2015
Mice doubly deficient in CD9 and a related tetraspanin, CD81, show pulmonary emphysema, weight loss, and osteopenia, a phenotype akin to human COPD.
MSC surface markers (CD44, CD73, and CD90) can identify human MSC-derived extracellular vesicles by conventional flow cytometry.
Del Cañizo et al., Salamanca, Spain. In Cell Commun Signal, Dec 2015
In addition, hMSC-derived EV were also positive for CD63 and CD81, the two characteristic markers of EV.
The immunomodulatory oligodendrocyte.
Schaeren-Wiemers et al., Basel, Switzerland. In Brain Res, Oct 2015
CD9, CD81), complement and complement receptor molecules (e.g.
[Study of immunomodulatory function of exosomes derived from human umbilical cord mesenchymal stem cells].
Xu et al., Guangzhou, China. In Zhonghua Yi Xue Za Zhi, Sep 2015
The expression of specific surface marker CD9 and CD81 were detected by Western blot, and the concentration of hUC-MSCs exosomes(hUC-MSCs-ex) was evaluated by BCA assay.
Claudins and pathogenesis of viral infection.
Baumert et al., Strasbourg, France. In Semin Cell Dev Biol, Jun 2015
Notable is the discovery of CLDN1 as an essential host factor for hepatitis C virus (HCV) entry, which led to detailed characterization of CLDN1 and its association with tetraspanin CD81 for the initiation of HCV infection.
[Research on hepatitis C virus entry inhibitor].
Zhu et al., In Bing Du Xue Bao, 2015
the process of HCV entering into host cell is the important step of drug intervention, in which HCV envelope protein El and E2, Host cell factors including Heparan sulfate(HS), CD81, scavenger receptor class B type I (SR-BI), Occludin (OCLD), Claudin (CLDN), low densitity lipoprotein receptor (LDLR), dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN), Liver/lymph node specific ICAM-3-grabbing integrin(L-SIGN), trans- ferrin receptor 1 (TfR1) and so on play a important role.
Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2.
Marcotrigiano et al., United States. In Nature, 2014
E2 binds to the host cell through interactions with scavenger receptor class B type I (SR-BI) and CD81, and serves as a target for neutralizing antibodies.
Hepatitis C virus E2 envelope glycoprotein core structure.
Law et al., Los Angeles, United States. In Science, 2013
The CD81 receptor binding site was identified by electron microscopy and site-directed mutagenesis and overlaps with the AR3C epitope.
Completion of the entire hepatitis C virus life cycle in genetically humanized mice.
Ploss et al., New York City, United States. In Nature, 2013
Building on the observation that CD81 and occludin (OCLN) comprise the minimal set of human factors required to render mouse cells permissive to HCV entry, we previously showed that transient expression of these two human genes is sufficient to allow viral uptake into fully immunocompetent inbred mice.
The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling.
Batista et al., London, United Kingdom. In Immunity, 2013
Here we show that cytoskeleton disruption triggered signaling requiring not only the B cell receptor (BCR), but also the coreceptor CD19 and tetraspanin CD81, thus providing a mechanism for signal amplification upon surface-bound antigen stimulation.
The CD19/CD81 complex physically interacts with CD38 but is not required to induce proliferation in mouse B lymphocytes.
Santos-Argumedo et al., Mexico. In Immunology, 2012
results indicate that the CD19/CD81 complex interacts with CD38 but this interaction is not required to induce proliferation in mouse B lymphocytes
Structural basis of ligand interactions of the large extracellular domain of tetraspanin CD81.
Overduin et al., Birmingham, United Kingdom. In J Virol, 2012
A novel membrane binding interface was revealed adjacent to the exposed HCV interaction site in the extracellular loop of CD81.
Significance of palmitoylation of CD81 on its association with tetraspanin-enriched microdomains and mediating hepatitis C virus cell entry.
Qi et al., Shanghai, China. In Virology, 2012
These results suggest that palmitoylation of CD81 should facilitate hepatitis C virus entry, at least in part, by regulating the association of CD81 with tetraspanin-enriched microdomains.
Clinical significance of CD81 expression by clonal plasma cells in high-risk smoldering and symptomatic multiple myeloma patients.
GEM (Grupo Español de Mieloma)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative et al., Salamanca, Spain. In Leukemia, 2012
our results show that CD81 may have a relevant role in MM pathogenesis and represent a novel adverse prognostic marker in myeloma.
Soluble serum CD81 is elevated in patients with chronic hepatitis C and correlates with alanine aminotransferase serum activity.
Kronenberger et al., Frankfurt am Main, Germany. In Plos One, 2011
Soluble serum CD81 is elevated in patients with chronic hepatitis C and correlates with alanine aminotransferase serum activity.
A genetically humanized mouse model for hepatitis C virus infection.
Ploss et al., New York City, United States. In Nature, 2011
Building on the previous observation that CD81 and occludin comprise the minimal human factors required to render mouse cells permissive to HCV entry in vitro, we attempted murine humanization via a genetic approach.
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