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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

CD8a molecule

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: CD4, CAN, HAD, V1a, Interleukin-2
Papers using CD8 antibodies
The Living Eye “Disarms” Uncommitted Autoreactive T Cells by Converting Them to Foxp3+ Regulatory Cells following Local Antigen Recognition
Gregerson Dale S. et al., In Frontiers in Immunology, 2011
... BG1 mice produce CD8 T cells expressing a transgenic Vβ7 TCR specific for ...
Modeling the competition between lung metastases and the immune system using agents.
Brusic Vladimir, In PLoS ONE, 2009
... all CD8 single positive T cells in the thymus express the transgenic TCR that is specific ...
Systematic analysis of a novel human renal glomerulus-enriched gene expression dataset
Fehr T et al., In Cell Death & Disease, 2009
... which expresses on all CD8 T cells a transgenic TCR selective for a naturally ...
MyD88 intrinsically regulates CD4 T-cell responses.
Gray Clive M., In PLoS ONE, 2008
CD8, PE-anti-mouse TCRβ, Alexa 700-anti-mouse tumor necrosis factor-α (TNF-α) and Allophycocyanin-anti-mouse IFN-γ were purchased from BD Biosciences (San Jose, CA) ...
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Hill Adrian VS et al., In Molecular Therapy, 2008
... The immunogenicity of adenovirus vectors limits the multispecificity of CD8 T-cell responses to vector-encoded transgenic antigens ...
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Papers on CD8
Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity.
Li et al., New York City, United States. In Nature, Feb 2016
Treg-cell-specific expression of an Akt-insensitive Foxo1 mutant prevented downregulation of lymphoid organ homing molecules, and impeded Treg cell homing to non-lymphoid organs, causing CD8(+) T-cell-mediated autoimmune diseases.
Comprehensive Immune Profiling of Lung Adenocarcinomas Reveals Four Immunosubtypes with Plasma Cell Subtype a Negative Indicator.
Sakamoto et al., In Cancer Immunol Res, Feb 2016
Cluster analysis revealed four distinct immunosubtypes (CD8, mast cell, macrophage/dendritic cell, and plasma cell subtypes) based on the infiltrating immune cell profiles.
CD8+ T cells mediate antibody-independent platelet clearance in mice.
Stowell et al., Atlanta, United States. In Blood, Feb 2016
Our studies demonstrate that CD8(+) T cells possess the unique ability to induce platelet clearance in the complete absence of anti-platelet alloantibodies.
The multifaceted role of CD4(+) T cells in CD8(+) T cell memory.
Kaech et al., New Haven, United States. In Nat Rev Immunol, Feb 2016
CD4(+) T cells are essential in the formation of protective memory CD8(+) T cells following infection or immunization.
Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+ T cells in aged mice.
La Gruta et al., Melbourne, Australia. In Proc Natl Acad Sci U S A, Feb 2016
UNASSIGNED: In advanced age, decreased CD8(+) cytotoxic T-lymphocyte (CTL) responses to novel pathogens and cancer is paralleled by a decline in the number and function of naïve CTL precursors (CTLp).
A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors.
Nerlov et al., Kettering, United States. In Nat Cell Biol, Feb 2016
Here we use the dependence of early, c-Kit-expressing thymic progenitors on Kit ligand (KitL) to show that CD4(-)CD8(-)c-Kit(+)CD25(-) DN1-stage progenitors associate with, and depend on, the membrane-bound form of KitL (mKitL) provided by a cortex-specific KitL-expressing vascular endothelial cell (VEC) population.
CCR5 blockade for neuroinflammatory diseases - beyond control of HIV.
Liblau et al., Toulouse, France. In Nat Rev Neurol, Feb 2016
On the basis of this evidence, we postulate in this Review that CCR5 antagonists, such as maraviroc, offer neuroprotective benefits in settings in which CCR5 promotes deleterious neuroinflammation, particularly in diseases in which CD8(+) T cells seem to play a pivotal role.
Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites.
Lieberman et al., Boston, United States. In Nat Med, Feb 2016
CD8(+) CTLs protect against parasite infections in mice primarily by secreting interferon (IFN)-γ.
AhR-dependent pathways in immune regulation.
Fallarino et al., Perugia, Italy. In Am J Transplant, Feb 2016
Allograft rejection is mostly a T-cell-mediated alloimmune response, initiated by the recognition of alloantigens presented by donor and recipient antigen-presenting cells to recipient CD4(+) and CD8(+) T cells.
Immune exhaustion and transplantation.
Markmann et al., Boston, United States. In Am J Transplant, Feb 2016
Although exhaustion has most commonly been studied in the context of CD8 viral responses, recent studies indicate that chronic antigen exposure may affect B cell, NK cells and CD4 T cells in a parallel manner.
When to Treat Adults Like Children: Optimizing Therapy for Lymphoblastic Lymphoma in Young Adults.
Advani et al., Cleveland, United States. In J Clin Oncol, Jan 2016
A subpopulation of T cells was positive for both CD4 and CD8.
Disturbances in apoptosis of lamina propria lymphocytes in Crohn's disease.
Linke et al., Poznań, Poland. In Arch Med Sci, Jan 2016
Each CD patient underwent colonoscopy with tissue sampling from inflamed areas of the colon with the assessment of immunohistochemical expression of active caspase 3, Fas, tumour necrosis factor receptor 1 (TNFR1), Bcl-2, Bax, CD4 and CD8.
Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences.
Ueno et al., Kumamoto, Japan. In Mbio, Dec 2015
UNLABELLED: HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8(+) T cells.
Natural Killer Cell Recognition of Melanoma: New Clues for a More Effective Immunotherapy.
Solana et al., Cáceres, Spain. In Front Immunol, 2014
However, melanoma cells frequently escape to CD8 T cell recognition by the down-regulation of major histocompatibility complex (MHC) class I molecules.
Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides.
Tunali et al., Bursa, Turkey. In J Immunol Res, 2014
Fluorescent labeled monoclonal antibodies were used to detect cell surface antigens: T cells (CD3(+), CD4(+), CD8(+), TCRαβ (+), TCRγδ (+), CD7(+), CD4(+)CD7(+), CD4(+)CD7(-), and CD71(+)), B cells (HLA-DR(+), CD19(+), and HLA-DR(+)CD19(+)), NKT cells (CD3(+)CD16(+)CD56(+)), and NK cells (CD3(-)CD16(+)CD56(+)).
Mechanistic insight into pertussis toxin and lectin signaling using T cells engineered to express a CD8α/CD3ζ chimeric receptor.
Miller et al., Cincinnati, United States. In Biochemistry, 2012
It was shown that CD8alpha/CD3zeta rescues pertussis toxin-induced signaling events lacking in TCR null cells, indicating that CD8alpha/CD3zeta can substitute for TCR and supports the hypothesis that pertussis toxin stimulates signaling via receptor cross-linking.
Frequency and prognostic impact of the aberrant CD8 expression in 5,523 patients with chronic lymphocytic leukemia.
Haferlach et al., München, Germany. In Cytometry B Clin Cytom, 2012
study confirms that CD8 expression is a recurrent albeit rare phenomenon in patients with chronic lymphocytic leukemia and suggests that CD8 expression has an adverse prognostic impact
Down-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins.
Kirchhoff et al., Ulm, Germany. In J Virol, 2012
Nef-mediated down-modulation of CD8alphabeta is a fundamental property of primate lentiviruses.
Silencing Hsp25/Hsp27 gene expression augments proteasome activity and increases CD8+ T-cell-mediated tumor killing and memory responses.
Asea et al., Temple, United States. In Cancer Prev Res (phila), 2012
Silencing Hsp25/Hsp27 gene expression augments proteasome activity and increases CD8+ T-cell-mediated tumor killing and memory responses
Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8α and promote its ubiquitylation and endocytosis.
Mottola et al., Napoli, Italy. In J Cell Sci, 2011
LNX1 and LNX2 interact with CD8alpha and promote its ubiquitylation and endocytosis.
More papers using CD8 antibodies
Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging
Effros Rita B. et al., In Journal of Clinical Immunology, 2008
... Cells were incubated with FITC-conjugated anti-CD4, PE-conjugated anti-CD28, allophycocyanin (APC)-conjugated anti-CD3, and PerCp-conjugated anti-CD8 (BD Biosciences, San Jose, CA) at ...
Regulation of cellular metabolism and cytokines by the medicinal herb feverfew in the human monocytic THP-1 Cells
Wu Rey-Yuh et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2008
... FITC-anti-CD3 and PE-anti-CD8 were purchased from Becton Dickinson-Pharmingen ...
Selective blockade of microRNA processing by Lin28.
Hartl Dominik, In PLoS ONE, 2007
... RNA was isolated from purified mouse naïve CD8 T cells as described earlier [41] using Qiagen miRNeasy kit according to ...
Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells.
Zimmer Jacques, In PLoS ONE, 2007
anti-CD4-APC, anti-CD4-FITC, and anti-CD28 (Biolegend, San Diego, CA, USA); anti-CD8-FITC (BD Biosciences, Chicago, IL, USA), and ...
SERS-Based Detection in an Optofluidic Ring Resonator Platform
Fan Xudong et al., In Sensors (Basel, Switzerland), 2006
... CD4 mouse monoclonal IgG antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) and CD8 mouse monoclonal antibodies were purchased from AbCam (Cambridge, MA) ...
Capture of membrane components via trogocytosis occurs in vivo during both dendritic cells and target cells encounter by CD8+ T cells
Blanco Julià et al., In Journal of Biomedicine and Biotechnology, 2006
... Purity of isolated populations (>95%) was assessed by flow cytometry after CD4 and CD8 staining (BD Biosciences).
Killing activity of co-cultured cytokine-induced killer cells and dendritic cells against multi-drug resistant tumor cell lines
Wang Zhongyu et al., In Clinical and Developmental Immunology, 2006
... anti-human CD3 (FITC labelled) monoclonal antibody, mouse anti-human CD56 (PE labelled) monoclonal antibody, mouse anti-human CD8 (PE labelled) monoclonal antibody, and mouse anti-human CD3 (unlabelled) monoclonal antibody were bought from eBioscience Co, Ltd ...
Cyclophosphamide enhances the antitumor efficacy of adoptively transferred immune cells through the induction of cytokine expression, B-cell and T-cell homeostatic proliferation, and specific tumor infiltration
Cacabelos R. et al., In Journal of Biomedicine and Biotechnology, 2006
... Fluorescein isothiocyanate-labeled mouse antihuman CD3, CDCD25 and CD69, and R-phycoerythrin-labeled mouse antihuman CD4, CD8, and HLA-DR were purchased from Becton Dickinson Biosciences (Erembodegem, Belgium) ...
Colorectal cancer and genetic alterations in the Wnt pathway.
Liebner Stefan, In PLoS ONE, 2005
... sequence encoding a Flag tag at the N terminus, and then cloned downstream of a sequence encoding the CD8 signal peptide (MALPVTALLLPLALLLHAA) in the vector pIRESpuro3 (Clontech) using standard, PCR-based molecular ...
Cytotoxic T-cell non-Hodgkin's lymphoma of the thyroid gland
Lee Young-Don et al., In Journal of Korean Medical Science, 2004
... methods using antibodies against CD3 (Dako, Glostrup, Denmark, prediluted), CD20 (Dako, prediluted), CD4 (Dako, prediluted), CD8 (Dako, prediluted), T-cell-restricted intracellular antigen-1 ...
Comparison of Salmonella enterica serovar Typhimurium colitis in germfree mice and mice pretreated with streptomycin
Waldor Matt, In PLoS Biology, 2004
... cells by using the MACS CD8 T cell isolation kit (Miltenyi Biotec, ...
Oral tolerance and its relation to food hypersensitivities.
Unutmaz Derya, In PLoS ONE, 2004
... Alexa-488, Alexa-647, and PE-labeled anti-mouse CD3, CD4, and CD8 antibodies and their isotype controls were from BioLegend.
Dynein-mediated vesicle transport controls intracellular Salmonella replication.
Unutmaz Derya, In PLoS ONE, 2003
... FITC-conjugated antibody IgG1, IgG2a and IgG2b, IgG1-PE and IgG1-APC isotype controls and PE-conjugated anti-CD8 blocking antibody were obtained from DAKO (Glostrup, Denmark) ...
Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures
Cybulsky Myron I. et al., In The Journal of Cell Biology, 2002
... allophycocyanin (APC)-conjugated CD49d clone 9F10 (BioLegend), APC-conjugated anti–human CD14 clone 61D3 (eBioscience), and FITC-conjugated anti–mouse CD8 (BioLegend).
Biodegradable nanoparticle mediated antigen delivery to human cord blood derived dendritic cells for induction of primary T cell responses
Minev Boris et al., In International Journal of Nanomedicine, 2002
... CD8 MicroBeads were purchased from Miltenyi Biotec (Auburn, CA) ...
Aberrant T-cell receptor signaling of interferon-gamma- and tumor necrosis factor-alfa-producing cytotoxic CD8+ Vdelta1/Vbeta16 T cells in a patient with chronic neutropenia
Maryniak Renata et al., In Arthritis Research & Therapy, 2002
... Denmark) (DAKO) using the following mono- and polyclonal antibodies: CD3, myeloperoxydase, hemoglobin (polyclonal), CD20 (L26), CD8 (C8/144B) (DAKO) and CD4 (4B12), CD57 ...
Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer
Nakajima Y et al., In British Journal of Cancer, 2002
... Immunohistochemical staining for CD45RO, CD4, and CD8 was performed with a Dako Envision kit (DAKO Cytomation, ...
De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients
Stein Harald et al., In Virchows Archiv, 2001
... CD8C8/144BCitrate1:100Dako ...
Reactive oxygen species as intracellular messengers during cell growth and differentiation
Mathews Clayton E. et al., In Diabetes, 2000
... Fluorescently labeled antibodies, Pacific blue–labeled anti-CD11b (M1/70), allophycocyanin (APC)-labeled anti-F4/80 (BM8), and phycoerythrin (PE)-labeled anti-CD8 (53–6.7)
Centromeric Repositioning of Coreceptor Loci Predicts Their Stable Silencing and the CD4/CD8 Lineage Choice
Brown Karen E. et al., In The Journal of Experimental Medicine, 1999
... ) were added to the cultures and thymocyte suspensions were stained with CD4-PE/Cy5 or -APC, CD8-PE or -FITC, and analyzed on a FACSCalibur (Becton Dickinson).
The MHC reactivity of the T cell repertoire prior to positive and negative selection
Davis Mark M. et al., In The Journal of Experimental Medicine, 1996
... CD8 expression allows T cell signaling by monomeric peptide-MHC complexes ...
Crystal structure of the conserved core of HIV-1 nef complexed with a Src family SH3 domain
McMichael Andrew J. et al., In The Journal of Experimental Medicine, 1995
... PE-conjugated anti-CD4 and CD8 mAbs were purchased from Beckton Dickinson (Mountain View, CA) and Dako Corp ...
Interleukin 2 and its receptors: recent advances and new immunological functions
Shakib Farouk et al., In The Journal of Experimental Medicine, 1995
... cell surface markers were purchased: anti-CD25 (ACT-1), anti-CD4 (MT310), anti-CD45RO (UCHL1), anti-CD2 (MT910), anti-CD3 (UCHT-1), anti-CD8 (DK25; Dako, Buckinghamshire, UK) and anti-CD69 ...
Increased cytolytic T lymphocyte activity and decreased B7 responsiveness are associated with CD28 down-regulation on CD8+T cells from HIV-infected subjects
Lier René A.W. van et al., In The Journal of Experimental Medicine, 1994
... FITC-conjugated–CD62L (Leu-8), –CD57, –CD16, –TCR-α/β, and –CD8 mAbs (Leu2a), and PE-conjugated– and PerCP-labeled CD8 mAb were from Becton Dickinson (San Jose, CA) ...
Hořejší Václav et al., In The Journal of Experimental Medicine, 1993
... ) thymocytes were isolated by flow sorting using anti–CD4-FITC (MEM-241), anti–CD8-PE (BD Biosciences), anti–CD2-PE (Immunotech), anti–CD4-biotin (Serotec), ...
Sequences in the cytoplasmic domain of CD4 are necessary and sufficient to confer sensitivity to the human immunodeficiency virus type 1 Vpu protein
Schubert Ulrich et al., In The Journal of Experimental Medicine, 1993
... an HIV-negative HLA A-2,3–positive donor by magnetic beads coupled with an mAb specific for human CD8 (Dianova GmbH, Hamburg, Germany) ...
IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Igα/β
Rajewsky Klaus et al., In The Journal of Experimental Medicine, 1990
... Non-tolerant B cells cause autoimmunity in anti-CD8 IgG2a-transgenic mice ...
Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity.
Das Hiranmoy, In PLoS ONE, 1985
... T cells were purified using the CD8 MicroBead Kit (Miltenyi Biotec), according to the manufacturer's ...
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