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Beta-1,3-glucuronyltransferase 1

CD57, HNK-1, Leu-7
The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD8, CD4, CD56, HAD, CAN
Papers using CD57 antibodies
Identification of a major co-receptor for primary isolates of HIV-1
Liu Yong-Jun et al., In The Journal of Experimental Medicine, 1995
... of the following FITC-conjugated antibodies: CD3 (Leu-4), CD14 (Leu-M3), CD15 (Leu-M1), CD16 (Leu-11a), CD20 (Leu-16), CD57 (Leu-7; all from Becton Dickinson), and CD11c (3.9; Caltag ...
Papers on CD57
Genetic Influence on the Peripheral Blood CD4+ T-cell Differentiation Status in CMV Infection.
Derhovanessian et al., Tübingen, Germany. In J Gerontol A Biol Sci Med Sci, Feb 2016
For further testing, we have analyzed middle-aged monozygotic (MZ, n = 42) and dizygotic (DZ, n = 39) twin pairs from the Danish Twin Registry for their T-cell differentiation status, assessed by surface expression of CD27, CD28, CD57, and KLRG-1.
Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.
Malmberg et al., Stockholm, Sweden. In J Immunol, Feb 2016
Hierarchical clustering of high-resolution immunophenotyping data covering key NK cell parameters, including frequencies of CD56(bright), NKG2A(+), NKG2C(+), and CD57(+) NK cell subsets, as well as the size of the educated NK cell subset, was linked to clinical outcomes.
HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain.
Sáez-Valero et al., San Juan de Alicante, Spain. In Mol Neurobiol, Feb 2016
Decrease in HNK-1 carrier glycoproteins were not paralleled by changes in messenger RNA (mRNA) levels of the enzymes involved in the synthesis of the glycoepitope, β-1,4-galactosyltransferase (β4GalT), glucuronyltransferases GlcAT-P and GlcAT-S, or sulfotransferase HNK-1ST.
Effect of age and latent CMV infection on CD8+CD56+ T cells (NKT-like) frequency and functionality.
Pera et al., Córdoba, Spain. In Mech Ageing Dev, Feb 2016
NKT-like cells expressing CD57 are expanded in CMV-seropositive individuals and are more polyfunctional than their CD57- counterpart.
HIV-Specific CD8+ T Cell-Mediated Viral Suppression Correlates With the Expression of CD57.
Karlsson et al., Copenhagen, Denmark. In J Acquir Immune Defic Syndr, Feb 2016
RESULTS: The expression of CD57 on effector CD8 T cells correlated with the suppression of HIV-1 replication and to the duration of ART.
Extranodal NK/T cell lymphoma and aggressive NK cell leukaemia: evidence for their origin on CD56+bright CD16-/+dim NK cells.
Lima, Porto, Portugal. In Pathology, Oct 2015
The tumour NK cells usually express brightly the CD56 adhesion molecule and CD94 lectin type killer receptor, and have an activation-related (cytoplasmic CD3ε, CD7, CD45RO, HLA-DR) phenotype; in contrast, CD16 and killer immunoglobulin-like receptors are frequently negative, and CD57 expression is almost never observed.
Natural killer cell maturation markers in the human liver and expansion of an NKG2C+KIR+ population.
Khakoo et al., Southampton, United Kingdom. In Lancet, Mar 2015
Mononuclear cells were isolated by ficoll separation and cell surface staining performed for CD3, CD56, CD16, CD57, CD117, CD161, CD158a, CD158b, CD49a, CD49b, CXCR6, NKG2C, and NKp46.
CD57 expression in CD8 T cells and development of cutaneous squamous cell carcinoma in renal transplant recipients: a prospective cohort study.
Wood et al., Oxford, United Kingdom. In Lancet, Mar 2015
CD57 expression might represent a marker of T-cell exhaustion; we hypothesised that expression could predict development of squamous cell carcinoma in renal transplant recipients, and undertook a prospective cohort study to assess its predictive value.
[Merkel cell carcinoma].
Cerroni et al., Graz, Austria. In Pathologe, 2014
chromogranin A and synaptophysin), neurofilament proteins, CD56, CD57, Bcl-2, TdT and PAX-5 are immunohistochemically positive.
Review of small cell carcinoma of the kidney with focus on clinical and pathobiological aspects.
Hes et al., Kōchi, Japan. In Pol J Pathol, 2014
Immunohistochemically, neoplastic cells show variable positivity for neuron-specific enolase, chromogranin A, synaptophysin, CD57 (Leu7) and CD56.
CMV induces rapid NK cell maturation in HSCT recipients.
Moretta et al., Genova, Italy. In Immunol Lett, 2013
In individuals experiencing HCMV reactivation after transplantation, NK cells rapidly achieved a fully differentiated stage of maturation, characterized by a KIR(+)NKG2A(-)NKG2C(+)CD57(+)p75/AIRM1(-) surface phenotype.
Functional Significance of CD57 Expression on Human NK Cells and Relevance to Disease.
Riley et al., London, United Kingdom. In Front Immunol, 2012
More recently it has been established that CD57 expression defines functionally discrete sub-populations of NK cells.
Lung CD57+ cell density is increased in very severe COPD.
Montes et al., Barcelona, Spain. In Histol Histopathol, 2012
CD57+ cells may be involved in chronic obstructive pulmonary disease pathogenesis, especially in the most severe stages of the disease.
Polymorphisms in B3GAT1, SLC9A9 and MGAT5 are associated with variation within the human plasma N-glycome of 3533 European adults.
Lauc et al., Edinburgh, United Kingdom. In Hum Mol Genet, 2012
33 directly measured and 13 derived glycosylation traits in 3533 individuals were identified and three novel gene association (MGAT5, B3GAT1 and SLC9A9) were identified using an additional European cohort.
Loss of CD127 & increased immunosenescence of T cell subsets in HIV infected individuals.
Kurapati et al., New Delhi, India. In Indian J Med Res, 2011
HIV infected subjects had higher percentage of T cell subsets expressing CD57.
Specific enzyme complex of beta-1,4-galactosyltransferase-II and glucuronyltransferase-P facilitates biosynthesis of N-linked human natural killer-1 (HNK-1) carbohydrate.
Oka et al., Kyoto, Japan. In J Biol Chem, 2011
the specific enzyme complex of beta4GalT-II with GlcAT-P plays an important role in the biosynthesis of HNK-1 carbohydrate.
Altered cytokine levels and increased CD4+CD57+ T cells in the peripheral blood of hepatitis C virus-related hepatocellular carcinoma patients.
Ichinose et al., Wakayama, Japan. In Oncol Rep, 2011
an increase in CD4+CD57+ T cells controls the capability of PB to produce the anti-tumor cytokine IFN-gamma and PB-IFN-gamma production is impaired with HCC tumor progression
Specification of the neural crest occurs during gastrulation and requires Pax7.
García-Castro et al., Pasadena, United States. In Nature, 2006
In chicken embryos, Pax7 is required for neural crest formation in vivo, because blocking its translation inhibits expression of the neural crest markers Slug, Sox9, Sox10 and HNK-1.
Migratory neural crest-like cells form body pigmentation in a urochordate embryo.
Yamamoto et al., College Park, United States. In Nature, 2004
These cells express HNK-1 antigen and Zic gene markers of vertebrate neural crest cells.
Oligosaccharide microarrays for high-throughput detection and specificity assignments of carbohydrate-protein interactions.
Chai et al., Watford, United Kingdom. In Nat Biotechnol, 2002
Initial applications have revealed new findings, including: (i) among O-glycans in brain, a relative abundance of the Lewis(x) sequence based on N-acetyllactosamine recognized by anti-L5, and a paucity of the Lewis(x) sequence based on poly-N-acetyllactosamine recognized by anti-SSEA-1; (ii) insights into chondroitin sulfate oligosaccharides recognized by an antiserum and an antibody (CS-56) to chondroitin sulfates; and (iii) binding of the cytokine interferon-gamma (IFN-gamma) and the chemokine RANTES to sulfated sequences such as HNK-1, sulfo-Lewis(x), and sulfo-Lewis(a), in addition to glycosaminoglycans.
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