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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Protein tyrosine phosphatase, receptor type, C

CD45, Glycoprotein, B220
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, CD34, Thy-1, V1a
Papers using CD45 antibodies
New insights into paracrine mechanisms of human cardiac progenitor cells
Garbade Jens et al., In ISRN Cardiology, 2009
... (Polyclonal rabbit Anti-Human CD 117, Dako) and the hematopoietic lineage markers CD3, CD11b, CD19, and CD45 (antihuman, BD Biosciences).
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
Gaits-Iacovoni F et al., In Blood Cancer Journal, 2009
... The following antibodies were used in this study: ALK (Sp8; Abcam, Cambridge, UK), B220/CD45R (RA3-6B2; AbD Serotec, Colmar, France), Rac1 (23A8; ...
Effect of fluid flow-induced shear stress on human mesenchymal stem cells: differential gene expression of IL1B and MAP K 38 in MAPK signaling
Shen Wei Feng et al., In Cardiovascular Diabetology, 2008
... CD90 (eBioscience, CA, USA) surface markers and negative for CD34 (Santa cruz, CA, USA) and CD45 (Abcam, Cambridge, UK) [ ...
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.
McCubrey James, In PLoS ONE, 2008
... IHC analysis: anti-GFP (Santa Cruz Biotechnology), anti-HIF-1α (BD Biosciences), FITC-conjugated mouse monoclonal anti-PIM (HPI, Inc), anti-CD45 (Cell Signaling Technology), anti-CD22 (Novocastra), anti-CXCR4 ...
NOD/Shi-scid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models
Ratajczak Mariusz Z et al., In Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007
... Cells were incubated with phycoerythrin (PE)-conjugated murine anti-human CD235a (clone GA-R2, BD Biosciences, USA), phycoerythrin-CY7 (PE-CY7)-CD45 (clone HI30, BD Biosciences), and allophycocyanin (APC)-conjugated CD133/2 ...
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Papers on CD45
Gene mutations of platelet glycoproteins and response to tirofiban in acute coronary syndrome.
Strunz et al., São Paulo, Brazil. In Sao Paulo Med J, Feb 2016
CONTEXT AND OBJECTIVES: Glycoprotein inhibitors (abciximab, eptifibatide and tirofiban) are used in patients with unstable angina and non-ST-segment elevation myocardial infarction before percutaneous coronary intervention.
Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification.
Levi et al., Ann Arbor, United States. In Ann Surg, Feb 2016
Bone-cartilage-stromal progenitor cells (CD105+/AlphaV+/Tie2-/CD45-/CD90-/BP1-) were also significantly decreased after lymph node excision (10.2% vs 0.5%, P < 0.05).
Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1.
Gao et al., Beijing, China. In Cell, Feb 2016
An endosomal protein, Niemann-Pick C1 (NPC1), has been identified as a necessary entry receptor for this process, and priming of the viral glycoprotein (GP) to a fusion-competent state is a prerequisite for NPC1 binding.
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis.
Grinstein et al., Toronto, Canada. In Cell, Feb 2016
We investigated how the major phosphatase CD45 is excluded from contact sites, using single-molecule tracking.
Unravelling the immunological roles of dipeptidyl peptidase 4 (DPP4) activity and/or structure homolog (DASH) proteins.
von Hörsten et al., Stuttgart, Germany. In Clin Exp Immunol, Jan 2016
UNASSIGNED: Dipeptidyl peptidase 4 (CD26, DPP4) is a multifunctional protein involved in T-cell activation by co-stimulation via its association with ADA, Caveolin-1, CARMA-1, CD45, M6P/IGFII-R and CXC-R4.
Effects Of Glycoprotein IIb/IIIa Antagonists: Anti Platelet Aggregation And Beyond.
Romano et al., Napoli, Italy. In Curr Drug Metab, Jan 2016
UNASSIGNED: The use of inhibitors of glycoprotein IIb/IIIa (GPIIb/IIIa) has provided dramatic results in terms of the prevention of acute stent thrombosis and a reduction in major adverse coronary events in patients subjected to percutaneous coronary intervention.
Antigen-specific immunotherapies for acute myeloid leukemia.
Walter et al., Seattle, United States. In Hematology Am Soc Hematol Educ Program, Jan 2016
Significant antileukemic activity is also well documented for radioimmunoconjugates targeting CD33, CD45, or CD66.
Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals.
Bond et al., In J Vis Exp, Dec 2015
Exosomes were identified on the basis of exosome markers acetylcholinesterase (AChE), and the CD9, CD63, and CD45 antigens.
Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.
Drewes et al., Heidelberg, Germany. In Nat Methods, Dec 2015
We also observed cellular thermal shifts in pervanadate-induced T cell-receptor signaling, delineating the membrane target CD45 and components of the downstream pathway, and with drugs affecting the transmembrane transporters ATP1A1 and MDR1.
Dynamic Viral Glycoprotein Machines: Approaches for Probing Transient States That Drive Membrane Fusion.
Lee et al., Seattle, United States. In Viruses, Dec 2015
In combination, the approaches provide a significantly richer portrait of viral fusion glycoprotein structural variation and fusion activation as well as inhibition by neutralizing agents.
EMERGE: A Randomized Phase II Study of the Antibody-Drug Conjugate Glembatumumab Vedotin in Advanced Glycoprotein NMB-Expressing Breast Cancer.
Vahdat et al., Nashville, United States. In J Clin Oncol, Jun 2015
PURPOSE: Glycoprotein NMB (gpNMB), a negative prognostic marker, is overexpressed in multiple tumor types.
An unusual tumour of the lung.
Sellami-Boudawara et al., In Pathologica, Mar 2015
The neoplastic mast cells stained strongly with tryptase, CD117, CD68 and CD45, CD14 and CD33; whereas the undifferentiated cells lacked all these markers and expressed EMA and cytokeratin.
Effect of platelet-rich plasma on healing tissues in acute ruptured Achilles tendon: a human immunohistochemistry study.
Franklin et al., Birmingham, United Kingdom. In Lancet, Mar 2015
Immunohistochemistry markers were used to identify collagen I and III, lymphocytes (CD45), proliferation (KI67), and blood vessels (CD34).
Genetic expression and functional characterization of the RUNX2 gene in human adult bone marrow mesenchymal stem cells.
Li et al., Shouguang, China. In Genet Mol Res, 2014
Flow cytometry data suggested 94.38% of MSCs were CD90-positive, while only 3.99 and 1.71% of total cells were positive for CD35 and CD45, respectively.
Research Note Mesenchymal stem cells from skin lesions of psoriasis patients promote proliferation and inhibit apoptosis of HaCaT cells.
Zhang et al., Taiyuan, China. In Genet Mol Res, 2014
Cell morphologies and multipotencies of skin MSCs were similar between the psoriasis group and healthy control group, with high levels of CD29, CD44, CD73, CD90, and CD105 and limited expression of CD34, CD45, and HLA-DR.
CD8+CD45RA+CCR7+FOXP3+ T cells with immunosuppressive properties: a novel subset of inducible human regulatory T cells.
Weyand et al., Stanford, United States. In J Immunol, 2012
Continuous culture of CD8+CCR7+ cells results in a population that is homogenously positive for CCR7 and CD45RA.
Dynamics of the splenic innate-like CD19⁺CD45Rlo cell population from adult mice in homeostatic and activated conditions.
Gaspar et al., Madrid, Spain. In J Immunol, 2012
CD19positive CD45R(lo)positive lymphocytes of embryonic origin are present in Peyer's patches and in the spleen throughout the life span of wild-type mice, beginning at postnatal day 7.
CD45-deficient severe combined immunodeficiency caused by uniparental disomy.
Wiest et al., Durham, United States. In Proc Natl Acad Sci U S A, 2012
Patient SNP array analysis revealed no change in copy number but loss of heterozygosity for entire length of chromosome 1, indicating that disease was caused by uniparental disomy with isodisomy of the entire maternal Chr1 bearing the mutant CD45 allele
Placental expression of CD100, CD72 and CD45 is dysregulated in human miscarriage.
Marzioni et al., Ancona, Italy. In Plos One, 2011
CD100, CD72 and CD45 were expressed in placenta and exhibited different mRNA and protein levels in normal pregnancy and miscarriage. Protein levels were highly dysregulated around 10 weeks of gestation in first and second miscarriage placentas.
CD40, CD45 CTLA-4 levels are elevated in healthy older adults.
Terzioglu et al., Antalya, Turkey. In Clin Lab, 2011
We found increased expression levels of CD40 and CD45 levels in healthy older versus younger individuals.
More papers using CD45 antibodies
Rho GTPase activation assays.
Beaudoin Claude, In PLoS ONE, 2007
... Fluorophore-conjugated antibodies anti-CD31 PE-Cy7, anti-CD34 efluor 450, anti-CD45 FITC, anti-Sca-1 PerCP Cy5-5 were from eBioscience (San Diego, CA, USA) ...
Erlotinib exhibits antineoplastic off-target effects in AML and MDS: a preclinical study
Pelus Louis M. et al., In Journal of Oncology, 2007
R-Phycoerythrin (PE) conjugated anti-mouse CD3 (clone 143-2C11), GR-1 (clone RB6-8C5), B220 (clone RA3-6B2), Mac1 (clone M1/70), Ter119 (clone Ter119), rat IgG2a, rat IgG2b, hamster IgG, and Streptavidin-PE-Cy7 were purchased from BD Biosciences (San Diego, CA) ...
Global and Local Architecture of the Mammalian microRNA-Transcription Factor Regulatory Network
Laitala-Leinonen Tiina et al., In Gene Regulation and Systems Biology, 2006
... surface markers Ly-6A/E stem cell antigen 1 (Sca-1) (BD Biosciences, U.S.A.), CD34 (Vision Biosystems, U.S.A.) and CD45 (Dako, Denmark) ...
Neurological disease in HIV-infected patients in the era of highly active antiretroviral treatment: a Brazilian experience
Adad Sheila Jorge et al., In AIDS Research and Treatment, 2005
... and for characterization of lymphoma: CD3 (Dako-CD3-Leu, T3), CD20 (Novocastra, NCL-CD20-L26), CD 30 (Dako-CD30 Ber-H2), CD45 (Dako CD45RO-UCHL1), CD45-LCA (Dako CD45, ...
CXCL13 neutralization reduces the severity of collagen-induced arthritis
Sármay Gabriella et al., In Biologics : Targets & Therapy, 2004
... mg/mL heat killed mycobacteria tuberculosis were purchased from Chondrex Inc (Redmond, WA), rat anti-mouse CD45R (B220)–PerCP/Cy5.5 and hamster anti-mouse CD11c–Alexa 647 from AbD Serotec (Oxford, UK) ...
Ontology Traverser: an R Package for GO Analysis
Dillin Andy, In PLoS Biology, 2004
... c-Kit-phycoerythrin (PE; eBioscience), and antibodies against the lineage markers: PE-Cy5 conjugated Mac-1, Gr-1, CD4, CD8, B220, and Ter119 (eBioscience).
Circulating endothelial cells as a marker of ongoing vascular disease in systemic sclerosis.
Rutherford Suzannah, In PLoS ONE, 2003
... with anti-CD133-phycoerythrin (PE) (Miltenyi Biotec), anti-CD34APC (Pharmingen), anti-CXCR4-PECY5 (Pharmingen), anti-CDw90 (Thy-1)-fluorescein-isotiocyanate (FITC, Pharmingen), anti-VEGFR(KDR)-FITC (Pharmingen), anti-CD45-FITC (Becton Dickinson Immunocytometry Systems, Mountain View, ...
IL-2 secretion by CD4+ T cells in vivo is rapid, transient, and influenced by TCR-specific competition
Marrack Philippa, In PLoS Biology, 2003
... Biotech, Auburn, California, United States) or sorted to greater than 98% purity after labeling with anti-B220 PE (BD Biosciences, San Diego, California, United ...
A statistical model for identifying proteins by tandem mass spectrometry.
Pfeffer Sebastien, In PLoS ONE, 2002
... analyzer (Sysmex Digitana, Horgen, Switzerland), as well as by flow cytometry for surface expression of CD45 with fluorescence-labeled antibodies (Becton Dickinson, Rotkreuz, Switzerland) ( ...
Transforming growth factor-beta: a neuroprotective factor in cerebral ischemia.
Reh Thomas A., In PLoS ONE, 2002
... passages, the cells were stained with rabbit anti-rat IgG monoclonal antibodies CD44, CD71, CD106, and CD45 diluted 1∶100 (sc-9099, sc-25590, Santa Cruz Biotechnology, Santa Cruz, CA, BA0321, ...
The SH3–SAM Adaptor HACS1 is Up-regulated in B Cell Activation Signaling Cascades
Stewart A. Keith et al., In The Journal of Experimental Medicine, 2002
... Anti-CD19 and anti-B220 microbeads were from Miltenyi Biotec Canada ...
Second Class Minors
Shastri Nilabh et al., In The Journal of Experimental Medicine, 2001
... system (Auburn, CA) with CD45R/B220-FITC conjugated mAb (BD Biosciences).
Cell Surface Organization of Stress-inducible Proteins ULBP and MICA That Stimulate Human NK Cells and T Cells via NKG2D
Davis Daniel M. et al., In The Journal of Experimental Medicine, 2001
... 5 μg/ml mouse anti–human CD45 mAb (HI30; BD Biosciences) and 10 μg/ml mouse ...
Identification of IFN-γ-producing CD4+ T cells following PMA stimulation.
Ross Susan, In PLoS Pathogens, 2000
... P14/Thy1.1 or P14/CD45.1 TCR transgenic mice specific for the ...
Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes.
Buday Laszlo, In PLoS ONE, 2000
... CD71:APC, P-STAT5(Y694):PE, and CD45:FITC conjugated antibodies used for flow cytometry and anti-CD45 used for western blotting were all purchased from BD Biosciences (San Jose, CA) ...
Exposure assessment of trichloroethylene
Lan Qing et al., In Frontiers in Oncology, 1999
... and immunostained with Abs recognizing the following: CD3 (UCHT1), CD4 (RPA-T4 or SK3), CD8 (SK1), CD45 (HI30), CD45RA (HI100), CCR7 (150503, R&D systems; all from BD Biosciences unless otherwise specified) ...
CD91a receptor for heat shock protein gp96
Henson Peter M. et al., In The Journal of Experimental Medicine, 1999
... Control antibodies consisted of monoclonal and polyclonal anti-CD45 antibodies (BD PharMingen and The Binding Site, respectively); chicken IgY and ...
Prox1 function is required for the development of the murine lymphatic system
Maurer Dieter et al., In The Journal of Experimental Medicine, 1998
... Primary nonconjugated mouse mAbs used were anti–VE-cadherin (Immunotech), -CD31 (Ancell), -CD44 (Bender MedSystems), -CD45 (Becton Dickinson), and Pal-E (Harlan Sera-Lab) ...
Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin
Gussoni Emanuela et al., In The Journal of Cell Biology, 1998
... cells/ml, and incubated with the following antibodies: anti-human CD34-FITC (BD Biosciences), anti-human CD133-PE (Miltenyi Biotec), anti-CD45-PE (Miltenyi Biotec), rat IgG-PE (BD Biosciences), ...
Phenotypic and functional characterization of mice that lack the type I receptor for IL-1
Galy Anne et al., In Molecular Therapy, 1996
... used for FACS analysis: pacific blue-labeled anti-CD4 (clone RM4-5; DB Bioscience, San Jose, CA), allophycocyanin-labeled anti-B220 (clone RA3-6B2; eBioscience, San Diego, CA), or ...
Targeted interleukin-2 therapy for spontaneous neuroblastoma metastases to bone marrow
Lesniak Maciej S., In PLoS ONE, 1996
... flow cytometry using the following antibodies: CD11b FITC (Serotec (Oxford, United Kingdom), CD34 PE (Serotec) CD45 CyC (BD Biosciences Pharmingen), CD9 FITC (BD ... A Service of the U.S. National Institute of Health
Winer Eric et al., In Journal of Hematology & Oncology, 1996
... Immunohistochemical analysis included a broad panel of antibodies against ALK1 (Dako, Carpinteria, CA; dilution 1:50), CD45 (Dako; dilution 1:400), CD4 (Novocastra, ...
Immune Tolerance After Delivery of Dying Cells to Dendritic Cells In Situ
Steinman Ralph M. et al., In The Journal of Experimental Medicine, 1995
... C57BL/6 (CD45.2) and TCR transgenic F5 mice, specific for ...
Collagen-induced arthritis in mice: synergistic effect of E. coli lipopolysaccharide bypasses epitope specificity in the induction of arthritis with monoclonal antibodies to type II collagen
Koteliansky Victor et al., In Molecular therapy. Nucleic acids, 1994
... Antibodies specific for NHP or human (h) hCD31, hCD11b, CD45, hCD20, hCD3 (BD Biosciences – Pharmingen) or for ...
An Early CD4+ T Cell–dependent Immunoglobulin A Response to Influenza Infection in the Absence of Key Cognate T–B Interactions
Doherty Peter C. et al., In The Journal of Experimental Medicine, 1993
and APC-conjugated mAbs to B220 and CD3ɛ (145-2C11; BD Biosciences).
Derivation of embryonic stem cell lines.
Green Douglas R., In PLoS Biology, 1992
... The anti-B220/CD45R and anti-CD3 used from B and T cell immunohistochemistry were purchased from BD Biosciences and Serotec, respectively ...
The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance
Stein-Streilein Joan et al., In The Journal of Experimental Medicine, 1991
Ab (1 mg/ml; Caltag Laboratories), PE- and Rhodamine-conjugated anti–mouse B220 Ab, Rhodamine-conjugated anti–mouse CD3 Ab (BD Biosciences), FITC-conjugated anti–mouse Mac-1 Ab ...
Requirements of class II-mediated B cell differentiation for class II cross-linking and cyclic AMP
Lutgens Esther, In PLoS ONE, 1990
... The purity of isolated B cells was monitored by FACS analysis using FITC-anti-mouse B220 Ab and FITC-anti-rat IgG Ab (eBioscience, San Diego, CA) ...
Skeletal complications in hairy cell leukemia: diagnosis and therapy
Sohani Aliyah R. et al., In Journal of Hematopathology, 1987
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