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CD44 molecule

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, V1a, CD45
Papers using CD44 antibodies
Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3)
Hawkins Shannon M., In PLoS ONE, 2011
... Monoclonal and polyclonal antibodies against CA125, fibroblast surface protein (FSP) and CD44 were obtained from Merck Millipore (MA, USA) ...
Expression and prognostic significance of THBS1, Cyr61 and CTGF in esophageal squamous cell carcinoma.
Tang Dean G., In PLoS ONE, 2008
... CD44 antibody used for Western Blot was purchased from Cell Signaling Technology ...
Drug-selected human lung cancer stem cells: Cytokine network, tumorigenic and metastatic properties.
Singh Amit, In PLoS ONE, 2007
... Primary antibodies used in the current study included: rabbit mAb to CD44 (Abcam) for Western blotting (1∶1,000), ...
SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis
Parton Robert G. et al., In The Journal of Cell Biology, 2006
... Antibodies used include Thy-1 and CD44 (Abcam); CHC, GM130, Grp78, Cav1, ...
Heterogeneous expression of Wnt/beta-catenin target genes within colorectal cancer.
Defossez Pierre-Antoine, In PLoS ONE, 2006
... San Diego CA); anti β-catenin mouse monoclonal antibody #19920/610153 (BD Transduction Laboratories, San Diego CA); anti-CD44 rat monoclonal antibody #103002 (BioLegend, San Diego, CA) and ...
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Papers on CD44
Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+ T cells in aged mice.
La Gruta et al., Melbourne, Australia. In Proc Natl Acad Sci U S A, Feb 2016
UNASSIGNED: In advanced age, decreased CD8(+) cytotoxic T-lymphocyte (CTL) responses to novel pathogens and cancer is paralleled by a decline in the number and function of naïve CTL precursors (CTLp).
Targeted Intracellular Protein Delivery Based on Hyaluronic Acid-Green Tea Catechin Nanogels.
Kurisawa et al., Singapore, Singapore. In Acta Biomater, Feb 2016
When CD44-overexpressing HCT-116 colon cancer cells were treated with GzmB-encapsulated HA-EGCG nanogels in vitro, significant cytotoxic effect was observed.
The ubiquitous hyaluronan: Functionally implicated in the oviduct?
Alvarez-Rodriguez et al., Linköping, Sweden. In Theriogenology, Jan 2016
Synthesis, binding (via the CD44 membrane receptor), and degradation of hyaluronan occur in male and female genital organs, the oviduct being no exception.
Biophysical regulation of Chlamydia pneumoniae-infected monocyte recruitment to atherosclerotic foci.
Ramasubramanian et al., San Antonio, United States. In Sci Rep, Dec 2015
Chlamydia pneumoniae infection is implicated in atherosclerosis although the contributory mechanisms are poorly understood.
Catch bond interaction allows cells to attach to strongly hydrated interfaces.
Rosenhahn et al., Bochum, Germany. In Biointerphases, Dec 2015
In this minireview, the authors discuss the general properties of hyaluronans and the occurrence and relevance of the CD44 catch-bond interaction in the context of hematopoiesis, cancer development, and leukemia.
New Findings on Breast Cancer Stem Cells: A Review.
Khazaei et al., Kermānshāh, Iran. In J Breast Cancer, Dec 2015
Since the introduction of the "cancer stem cell" theory, significant developments have been made in the understanding of cancer and the heterogenic structure of tumors.
Increased activity of CHK enhances the radioresistance of MCF-7 breast cancer stem cells.
Jiang et al., Suzhou, China. In Oncol Lett, Dec 2015
Radiotherapy may also regulate the proportion of CD44(+)/CD24(-) MCF-7 cancer stem cells in a dose- and time-dependent manner.
Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein.
Daugaard et al., Copenhagen, Denmark. In Cancer Cell, Nov 2015
In tumors, placental-like CS chains are linked to a limited repertoire of cancer-associated proteoglycans including CD44 and CSPG4.
Alternative 3' UTRs act as scaffolds to regulate membrane protein localization.
Mayr et al., New York City, United States. In Nature, Jul 2015
About half of human genes use alternative cleavage and polyadenylation (ApA) to generate messenger RNA transcripts that differ in the length of their 3' untranslated regions (3' UTRs) while producing the same protein.
Immunosurveillance of the liver by intravascular effector CD8(+) T cells.
Iannacone et al., Milano, Italy. In Cell, May 2015
Here, we used advanced imaging in mouse models of hepatitis B virus (HBV) pathogenesis to understand the mechanisms whereby these cells home to the liver, recognize antigens, and deploy effector functions.
The role of CD44 in epithelial-mesenchymal transition and cancer development.
Wu et al., Wuhan, China. In Onco Targets Ther, 2014
CD44, a multi-structural and multifunctional transmembrane glycoprotein, was initially identified as a receptor for hyaluronan that participates in both physiological and pathological processes.
Aberrant Splicing of Estrogen Receptor, HER2, and CD44 Genes in Breast Cancer.
Fry et al., Winston-Salem, United States. In Genet Epigenet, 2014
While a number of splicing alterations have been reported in human cancers, we focus on aberrant splicing of ER, HER2, and CD44 genes from the viewpoint of BC development.
Optimization of immunostaining on flat-mounted human corneas.
He et al., Saint-Étienne, France. In Mol Vis, 2014
Second, optimized immunostaining protocols were applied to fresh corneas for three applications: identification of rare cells that express KI67 in the endothelium of specimens with Fuch's endothelial corneal dystrophy (FECD), the precise localization of neural cell adhesion molecules (NCAMs) in normal ECs and of the cytokeratin pair K3/12 and CD44 in normal epithelial cells, and the identification of cells that express S100b in the normal epithelium.
Intracellular autofluorescence: a biomarker for epithelial cancer stem cells.
Heeschen et al., Madrid, Spain. In Nat Methods, 2014
Although surface markers such as CD133 and CD44 have been successfully used to isolate CSCs, their expression is not exclusively linked to the CSC phenotype and is prone to environmental alteration.
T cells are Smad'ly in love with galectin-9.
Cummings, Atlanta, United States. In Immunity, 2014
Galectin-9 interacts with CD44 in association with TGF-β receptors to drive both Foxp3 and galectin-9 expression in a positive-feedforward loop involving Smad3 activation.
Osteopontin is upregulated after mechanical brain injury and stimulates neurite growth from hippocampal neurons through β1 integrin and CD44.
Plantman, Stockholm, Sweden. In Neuroreport, 2012
after experimental TBI, hippocampal neurons grew well on an OPN substrate with growth comparable to that seen on laminin, but showed a higher degree of primary neurites; growth on OPN was mediated through beta1 intregrins and CD44. T
LRP-1--CD44, a new cell surface complex regulating tumor cell adhesion.
Dedieu et al., Reims, France. In Mol Cell Biol, 2012
LRP-1--CD44 is a new cell surface complex regulating tumor cell adhesion
Decreased immunoexpression of standard form of CD44 is an independent favourable predictor of nodal metastasis in colorectal carcinoma.
Al-Ahwal et al., Jiddah, Saudi Arabia. In Anticancer Res, 2012
Loss of CD44s immunolabelling in colorectal carcinoma is an independent favourable predictor of regional lymph node metastasis. On the other hand, CD44s loss has no significant association with disease recurrence or survival.
CD44 in human glioma correlates with histopathological grade and cell migration.
Ishiwata et al., Tokyo, Japan. In Pathol Int, 2012
CD44 expression levels correlated with the histopathological grade of gliomas, and monoclonal anti-CD44 antibody inhibited the migration of glioblastoma cells.
Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.
Nagano et al., Tokyo, Japan. In Nat Commun, 2011
Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.
More papers using CD44 antibodies
CellProfiler: image analysis software for identifying and quantifying cell phenotypes.
Saks Valdur, In PLoS ONE, 2005
... Anti-CD44 (MEM-263) was from EXBIO Praha (Czech Republic) ...
Tumor necrosis factor inhibitors for rheumatoid arthritis
Roodman G David et al., In Journal of Bone and Mineral Research, 2005
... , cFms, RANK, TRAF6, and CD44 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization
Collard John G. et al., In The Journal of Cell Biology, 2005
... Antibodies against ezrin and CD44 were purchased from BD Biosciences.
The role of hyaluronan synthase 3 in ventilator-induced lung injury.
Zissel Gernot, In PLoS ONE, 2004
... To ligate surface receptors, PBMC were cultured in SFM with 2 µg/ml anti-human CD44 (clone G44-26) (BD Biosciences, San Jose, CA), anti-human ...
Epidermal Growth Factor Induces WISP-2/CCN5 Expression in Estrogen Receptor-{alpha}-Positive Breast Tumor Cells through Multiple Molecular Cross-talks
Banerjee Snigdha et al., In Molecular Cancer, 2004
... Keratin-19 were purchased from BD Transduction Laboratory (San Jose, CA), rabbit polyclonal anti-human Oct-4 and CD44 were purchased from Cell Signaling (Boston, MA) ...
Inverted signaling hierarchy between RAS and RAC in T-lymphocytes
Shaw Stephen et al., In The Journal of Cell Biology, 2003
... (Sigma-Aldrich), moesin-specific mAb 38/87 (NeoMarkers), major histocompatibility complex I–specific rabbit mAb (Epitomics), Alexa Fluor 488–conjugated CD44 mAb (BioLegend), and HRP-conjugated Penta-His antibody ...
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells.
Zhou Zhongjun, In PLoS ONE, 2002
... Technology (Beverly, MA, anti-β-actin and anti-α,β-tubulin antibodies), Santa Cruz (Santa Cruz, CA, anti-vimentin, anti-cytokeratin8/18, anti-HCAM (CD44) and anti-HoxD10 antibodies), BD Biosciences (San Jose, CA, anti-HIF-1αantibody), ...
CD44 modulates Smad1 activation in the BMP-7 signaling pathway
Knudson Cheryl B. et al., In The Journal of Cell Biology, 2002
... After transfection, the anti–human CD44 mAb BU-52 (The Binding Site), which recognizes an extracellular ...
Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells
Butz Eric A. et al., In The Journal of Experimental Medicine, 1999
... enrichment cocktail (Stem Cell Technologies) and sorting according to expression of CD8, CD44, and CD122 (IL-2Rβ) using a FACSVantage™ (Becton Dickinson).
Complementary Role of CD4+ T Cells and Secondary Lymphoid Tissues for Cross-presentation of Tumor Antigen to CD8+ T Cells
Fu Yang-Xin et al., In The Journal of Experimental Medicine, 1998
... antibody, PE-coupled anti-IFNγ antibody, isotype control PE-coupled rat IgG1 antibody, cy-chrome (CyC)-coupled streptavidin, and CyC-coupled anti-CD44 antibody were purchased from BD Biosciences.
Prox1 function is required for the development of the murine lymphatic system
Maurer Dieter et al., In The Journal of Experimental Medicine, 1998
... Primary nonconjugated mouse mAbs used were anti–VE-cadherin (Immunotech), -CD31 (Ancell), -CD44 (Bender MedSystems), -CD45 (Becton Dickinson), and ...
Caldendrin, a novel neuronal calcium-binding protein confined to the somato-dendritic compartment.
Finkelstein David, In PLoS ONE, 1997
... were purchased from Chemicon (MAP2), Abcam (GFAP), Fisher Scientific (anti-CD44, clone OX-50), Lifespan Biosciences (NCAM1 extracellular domain) ...
Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow
Kinashi Tatsuo et al., In The Journal of Cell Biology, 1997
... MVCAM-A,429 (anti–mouse VCAM-1) and anti–mouse CD44 were purchased from BD Biosciences.
Rhamm−/− fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair
Turley Eva A. et al., In The Journal of Cell Biology, 1997
... (Santa Cruz Biotechnology, Inc.), Ki67 (immunohistochemistry; DakoCytomation), tenascin (immunohistochemistry; Chemicon), phospho-ERK1,2 (immunohistochemistry/Western blot/immunofluorescence; Cell Signaling), CD44 (Western blot/immunofluorescence/blocking; IM7; BD Biosciences), CD44 (blocking; Hermes-3; a gift ...
Targeted interleukin-2 therapy for spontaneous neuroblastoma metastases to bone marrow
Lesniak Maciej S., In PLoS ONE, 1996
... CD90 PE (BD Biosciences Pharmingen), CD73 PE (BD Biosciences Pharmingen), CD105 FITC (Diaclone, Besancon, France), CD44 FITC (BD Biosciences Pharmingen) and CD29 PE ...
Cell–matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation
Saya Hideyuki et al., In The Journal of Cell Biology, 1996
... The mAb directed against the ectodomain epitope of CD44 (BU52) was obtained from Ancell.
Acinar differentiation by non-malignant immortalized human prostatic epithelial cells and its loss by malignant cells.
Waalkes Michael P. et al., In Environmental Health Perspectives, 1996
... CA); anti-OCT4 (Santa Cruz Biotechnology Inc., Santa Cruz, CA); anti-CXCR4, (Calbiochem, San Jose, CA); and anti-CD44 (Abcam Inc., Cambridge, MA).
Consumption of dairy produce and alcohol in a case-control study of breast cancer
Bieberich Erhard et al., In Breast Cancer Research : BCR, 1985
... Polyclonal anti-CD44 rabbit IgG was from Abcam (Cambridge, MA, USA) ...
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