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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

CD38 molecule

CD38, ADP-ribosyl Cyclase
CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, HAD, CAN, CD34, CD8
Papers using CD38 antibodies
Roundabout 4 is expressed on hematopoietic stem cells and potentially involved in the niche-mediated regulation of the side population phenotype
Clarkson B et al., In Blood Cancer Journal, 2008
... APC-anti-CD38 was purchased from eBioscience (San Diego, CA, USA) ...
SOCS proteins: negative regulators of cytokine signaling.
Hartl Dominik, In PLoS ONE, 2000
... 555821, 10 µl per sample), CD38-PerCP/Cy5.5 (BioLegend, Uithoorn, The Netherlands, Cat ...
Sequential use of paraformaldehyde and methanol as optimal conditions for the direct quantification of ZEBRA and rta antigens by flow cytometry
Speck Samuel H., In PLoS Pathogens, 1999
... Cells were stained with anti-human CD19 (coupled to eFluor 450; eBioscience), anti-human CD38 (clone HIT2, coupled to PE; eBioscience), anti-human IgD (coupled to ...
Efficient retroviral-mediated gene transfer to human cord blood stem cells with in vivo repopulating potential
Coulombel Laure et al., In The Journal of Experimental Medicine, 1997
... cells were sorted and relabeled with CD34-PE-Cy5 (Immunotech) and either CD38-PE (Becton Dickinson ...
The lineage commitment of haemopoietic progenitor cells
Lansdorp Peter M. et al., In The Journal of Experimental Medicine, 1996
... In brief, cells were labeled with OKT-9–FITC (anti-CD71), 8G12-Cy-5 (anti-CD34), 8d2-PE (anti-CD45RA), and Leu-17–PE (anti-CD38; Becton Dickinson ...
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Papers on CD38
Daratumumab: First Global Approval.
McKeage, Auckland, New Zealand. In Drugs, Feb 2016
Daratumumab (Darzalex™) is a first-in-class, humanized IgG1κ monoclonal antibody that targets the CD38 epitope and was developed by Janssen Biotech and Genmab.
Dominant enrichment of phenotypically activated CD38(+) HLA-DR(+) CD8(+) T cells, rather than CD38(+) HLA-DR(+) CD4(+) T cells, in HIV/HCV coinfected patients on antiretroviral therapy.
Vullo et al., Roma, Italy. In J Med Virol, Feb 2016
METHODS: We determined T lymphocytes subsets to characterize immune-activation defined as CD38 and/or HLA-DR expression in chronic monoinfected HCV, HIV, and HIV/HCV coinfected subjects.
A higher frequency of CD4(+)CXCR5(+) T follicular helper cells in patients with newly diagnosed Henoch-Schönlein purpura nephritis.
Jiang et al., Changchun, China. In Int Immunopharmacol, Feb 2016
The numbers of circulating CD4(+)CXCR5(+), CD4(+)CXCR5(+)ICOS(+) and CD4(+)CXCR5(+)PD-1(+) TFH cells, CD86(+)CD19(+), CD38(+)CD19(+) B cells and serum IL-2, IL-4, IL-17A, IL-21 and IFN-γ were significantly higher in HSPN patients (p<0.05)
ESAM is a novel human hematopoietic stem cell marker associated with a subset of human leukemias.
Kanakura et al., Suita, Japan. In Exp Hematol, Feb 2016
Multipotent colony-forming units and long-term hematopoietic-reconstituting cells in immunodeficient mice were exclusively found in the ESAM(High) fraction of CD34(+) CD38(-) cells.
Prognostic Factors for Chronic Lymphocytic Leukemia.
Puvvada et al., Tucson, United States. In Curr Hematol Malig Rep, Feb 2016
The prognostic information can be categorized into three categories: genetic abnormalities which include 17p, 11q, and immunoglobulin heavy chain variable (IGHV) abnormalities; biochemical abnormalities and cell surface markers which include serum thymidine kinase, β-2-microglobulin, CD49d, CD38, and ZAP-70 levels; and patient characteristics which include sex, age, and performance status.
High proportion of CD95(+) and CD38(+) in cultured CD8(+) T cells predicts acute rejection and infection, respectively, in kidney recipients.
Paz-Artal et al., Madrid, Spain. In Transpl Immunol, Feb 2016
We prospectively examined T-lymphocyte subsets after cell culture stimulation (according to CD38, CD69, CD95, CD40L, and CD25 expression) in 79 first graft recipients from four centers, before and after transplantation.
Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial.
Voorhees et al., Atlanta, United States. In Lancet, Feb 2016
We assessed daratumumab, a novel CD38-targeted monoclonal antibody, in patients with refractory multiple myeloma.
Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: Pathophysiological implications and therapeutic potential.
Mericskay, Paris, France. In Arch Cardiovasc Dis, Jan 2016
Nicotinamide adenine dinucleotide (NAD(+)/NADH) is a major coenzyme for oxidoreduction reactions in energy metabolism; it has recently emerged as a signalling molecule with a broad range of activities, ranging from calcium (Ca(2+)) signalling (CD38 ectoenzyme) to the epigenetic regulation of gene expression involved in the oxidative stress response, catabolic metabolism and mitochondrial biogenesis (sirtuins, poly[adenosine diphosphate-ribose] polymerases [PARPs]).
Clinical efficacy and management of monoclonal antibodies targeting CD38 and SLAMF7 in multiple myeloma.
Richardson et al., Amsterdam, Netherlands. In Blood, Jan 2016
Of these agents, CD38-targeting antibodies have marked single agent activity in extensively pretreated MM, and preliminary results from studies with relapsed/refractory patients have shown enhanced therapeutic efficacy when daratumumab and isatuximab are combined with other agents.
Somato-axodendritic release of oxytocin into the brain due to calcium amplification is essential for social memory.
Higashida, Kanazawa, Japan. In J Physiol Sci, Dec 2015
CD38-dependent cyclic ADP-ribose (cADPR) is also involved in this autoregulation by elevating [Ca(2+)] i via Ca(2+) mobilization through ryanodine receptors on intracellular Ca(2+) pools that are sensitive to both Ca(2+) and cADPR.
CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia.
Cleary et al., Stanford, United States. In Cell Stem Cell, Nov 2015
Although human CD34(+)CD38(-) LSCs are generally highly quiescent, the C-type lectin CD93 is expressed on a subset of actively cycling, non-quiescent AML cells enriched for LSC activity.
Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma.
Richardson et al., Utrecht, Netherlands. In N Engl J Med, Oct 2015
BACKGROUND: Multiple myeloma cells uniformly overexpress CD38.
Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues.
Sitnicka et al., Lund, Sweden. In Immunity, Sep 2015
Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) population represents a NK lineage-restricted progenitor (NKP) in fetal development, umbilical cord blood, and adult tissues.
Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow.
Lee et al., Atlanta, United States. In Immunity, Aug 2015
Here we used CD19, CD38, and CD138 to identify four PC subsets in human bone marrow (BM).
Effects of CD3McAb and rhIL-2 activated bone marrow on the killing and purging of leukemia cells.
Wang et al., Xi'an, China. In Genet Mol Res, 2014
Compared with bone marrow activated by rhIL-2 or CD3McAb alone, the synergistic effect of both CD3McAb+ and hIL-2 caused significant increase of CD3(+), CD8(+), CD19(+), CD25(+), CD38(+), and CD56(+) levels.
CD38 gene polymorphism and risk of chronic lymphocytic leukemia.
Dyagil et al., Ukraine. In Leuk Res, 2012
CD38 gene polymorphism is associated with chronic lymphocytic leukemia.
The CD19/CD81 complex physically interacts with CD38 but is not required to induce proliferation in mouse B lymphocytes.
Santos-Argumedo et al., Mexico. In Immunology, 2012
results indicate that the CD19/CD81 complex interacts with CD38 but this interaction is not required to induce proliferation in mouse B lymphocytes
miR-140-3p regulation of TNF-α-induced CD38 expression in human airway smooth muscle cells.
Kannan et al., Saint Paul, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
miR-140-3p modulates CD38 expression in human airway smooth muscle cells through direct binding to the CD38 untranslated region and indirect mechanisms involving activation of p38 MAPK and NF-kappaB.
The role of CD38 in Fcγ receptor (FcγR)-mediated phagocytosis in murine macrophages.
Kim et al., Chŏnju, South Korea. In J Biol Chem, 2012
a crucial role of CD38 in FcgammaR-mediated phagocytosis through its recruitment to the phagosome and mobilization of cADPR-induced intracellular Ca(2+) and store-operated extracellular Ca(2+) influx.
Mice deficient in CD38 develop an attenuated form of collagen type II-induced arthritis.
Merino et al., Santander, Spain. In Plos One, 2011
CD38 participates in the pathogenesis of collagen-induced arthritis controlling the number of iNKT cells and promoting Th1 inflammatory responses.
More papers using CD38 antibodies
Silencing of B Cell Receptor Signals in Human Naive B Cells
Müschen Markus et al., In The Journal of Experimental Medicine, 1996
... GC B cells were depleted using an anti-CD38 PE antibody (BD Biosciences) together with anti-PE microbeads ...
The chemokine SDF-1, stromal cell–derived factor 1, attracts early stage B cell precursors via the chemokine receptor
Springer Timothy A. et al., In The Journal of Experimental Medicine, 1996
... adhesion molecule (ICAM)-1–PE, and anti-CD20-FITC and -PerCP, anti-CD44-FITC, anti-CD56-FITC, anti-CD62 ligand (L)-FITC, anti-CD3-PerCP, anti-CD14-PE, and anti-CD38-PE from Becton Dickinson ...
CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype
Fearon Douglas T. et al., In The Journal of Experimental Medicine, 1995
... (Becton Dickinson, Oxford, UK) after labeling cells with FITC-conjugated anti-CD19 (Coulter Corp.) and PE-conjugated anti-CD38 mAbs (Becton Dickinson).
Immunoglobulin gene hyperconversion ongoing in chicken splenic germinal centers
Nussenzweig Michel C. et al., In The Journal of Experimental Medicine, 1995
... , Piscataway, NJ), which was visualized with streptavidin-FITC (Immunotech, Westbrook, ME), and PE-labeled mouse anti–human CD38 (Becton Dickinson ...
Protein tyrosine phosphorylation is mandatory for CD40-mediated rescue of germinal center B cells from apoptosis
Liu Yong-Jun et al., In The Journal of Experimental Medicine, 1992
... mAbs used for the phenotypic studies were FITC-conjugated anti-CD20 (IOB20; Immunotech, Marseille, France) and PE-conjugated anti-CD38 (Leu17; Becton Dickinson ...
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