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CD300a molecule

CD300a, IRp60, CMRF-35H, NK inhibitory receptor
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: CAN, MHC, MAST, IgE, V1a
Papers on CD300a
The Biology and Disease Relevance of CD300a, an Inhibitory Receptor for Phosphatidylserine and Phosphatidylethanolamine.
Borrego et al., Barakaldo, Spain. In J Immunol, Jul 2015
The CD300a inhibitory receptor belongs to the CD300 family of cell surface molecules that regulate a diverse array of immune cell processes.
Involvement of CD300a Phosphatidylserine Immunoreceptor in Aluminum Salt Adjuvant-Induced Th2 Responses.
Shibuya et al., Tsukuba, Japan. In J Immunol, Jul 2015
In an experimental allergic airway inflammation model, in which alum in conjunction with OVA Ag was i.p. injected for immunization, we found that apoptotic cells and inflammatory dendritic cells (iDC) expressing CD300a, an inhibitory immunoreceptor for phosphatidylserine (PS), significantly increased in number in the peritoneal cavity after the immunization.
Chicken CD300a homolog is found on B lymphocytes, various leukocytes populations and binds to phospholipids.
Göbel et al., München, Germany. In Dev Comp Immunol, Jun 2015
The chicken CD300 cluster contains three genes that encode inhibitory, activating and soluble forms.
Pseudorabies Virus US3 Protein Kinase Protects Infected Cells from NK Cell-Mediated Lysis via Increased Binding of the Inhibitory NK Cell Receptor CD300a.
Favoreel et al., Merelbeke, Belgium. In J Virol, 2014
Here we report that the US3 protein kinase of the alphaherpesvirus pseudorabies virus (PRV) displays previously uncharacterized immune evasion properties: it triggers the binding of the inhibitory NK cell receptor CD300a to the surface of the infected cell, thereby providing increased CD300a-mediated protection of infected cells against NK cell-mediated lysis.
Granulin-epithelin precursor renders hepatocellular carcinoma cells resistant to natural killer cytotoxicity.
Cheung et al., Hong Kong, Hong Kong. In Cancer Immunol Res, 2014
GEP downregulated surface expression of MHC class I chain-related molecule A (MICA), ligand for NK stimulatory receptor NK group 2 member D (NKG2D), and upregulated human leukocyte antigen-E (HLA-E), ligand for NK inhibitory receptor CD94/NKG2A.
The Phosphatidylserine and Phosphatidylethanolamine Receptor CD300a Binds Dengue Virus and Enhances Infection.
Amara et al., Paris, France. In J Virol, 2014
We show here that human CD300a, a recently identified phospholipid receptor, also binds directly DENV particles and enhances viral entry.
Identification of CD300a as a new hypoxia-inducible gene and a regulator of CCL20 and VEGF production by human monocytes and macrophages.
Bosco et al., Genova, Italy. In Innate Immun, 2014
In this study, we identify the leukocyte membrane antigen, CD300a, a member of the CD300 superfamily of immunoregulatory receptors, as a new hypoxia-inducible gene in primary human monocytes and monocyte-derived macrophages.
Molecular targets on mast cells and basophils for novel therapies.
Maurer et al., Kuopio, Finland. In J Allergy Clin Immunol, 2014
Surface-activating receptors, such as CD48 and thymic stromal lymphopoietin receptors, as well as inhibitory receptors, such as CD300a, FcγRIIb, and endocannabinoid receptors, hold promising therapeutic possibilities based on preclinical studies.
Role of phosphatidylserine receptors in enveloped virus infection.
Chen et al., Los Angeles, United States. In J Virol, 2014
In this study, we examined most of the known human phosphatidylserine-recognizing molecules, including MFG-E8, TIM-1, -3, and -4, CD300a, BAI1, and stabilin-1 and -2, for their abilities to facilitate virus binding and infection.
Roles of eosinophils in the modulation of angiogenesis.
Levi-Schaffer et al., Jerusalem, Israel. In Chem Immunol Allergy, 2013
Infiltrated eosinophils respond to hypoxia by increasing their viability and proangiogenic potential and regulate the expression of receptors particularly CD300a.
PPARβ/δ activation of CD300a controls intestinal immunity.
Sakai et al., Tokyo, Japan. In Sci Rep, 2013
Here, we show that PPARβ/δ (peroxisome proliferator-activated receptor β/δ) directly regulates CD300a in macrophages that express the immunoreceptor tyrosine based-inhibitory motif (ITIM)-containing receptor.
The CD300 molecules: an emerging family of regulators of the immune system.
Borrego, Bethesda, United States. In Blood, 2013
For instance, one member of the family, CD300a, has been studied as a possible biomarker.
CD300a is expressed on human basophils and seems to inhibit IgE/FcεRI-dependent anaphylactic degranulation.
Ebo et al., Antwerp, Belgium. In Cytometry B Clin Cytom, 2012
CD300a is expressed on human peripheral blood basophils and rapidly up-regulated upon cross-linking of IgE/Fc-epsilon-RI and suppresses anaphylactic degranulation.
Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells.
Borrego et al., Bethesda, United States. In Blood, 2012
our results indicate that phosphatidylethanolamine and phosphatidylserine are ligands for CD300a, and that this interaction plays an important role in regulating the removal of dead cells.
Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor.
Shibuya et al., Tsukuba, Japan. In Biochem Biophys Res Commun, 2012
These results indicated that CD300a is a new phosphatidylserine receptor.
Functional requirements for inhibitory signal transmission by the immunomodulatory receptor CD300a.
Borrego et al., Bethesda, United States. In Bmc Immunol, 2011
SHP-1, but not SHP-2 or the src homology 2 domain containing inositol 5' phosphatase SHIP, was utilized by CD300a for its inhibitory activity. These studies provide new insights into the function of CD300a in tuning T and B cell responses.
Differential expression of CD300a/c on human TH1 and TH17 cells.
Borrego et al., Bethesda, United States. In Bmc Immunol, 2010
differential expression on human TH1 and TH17 cell memory subsets
Are we ready to downregulate mast cells?
Levi-Schaffer et al., Jerusalem, Israel. In Curr Opin Immunol, 2009
Human MCs (hMCs) have been recently shown to express the death receptor (DR) TRAIL and the inhibitory receptors (IRs) CD300a and Siglec-8.
Interaction of the NK cell inhibitory receptor Ly49A with H-2Dd: identification of a site distinct from the TCR site.
Margulies et al., Bethesda, United States. In Immunity, 1999
We describe the binding of bacterially expressed Ly49A, the prototype murine NK inhibitory receptor, to similarly engineered H-2Dd.
Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor.
Coulie et al., Brussels, Belgium. In Immunity, 1997
The CTL expresses an NK inhibitory receptor that inhibits its lytic activity upon interaction with HLA-Cw7 molecules, which are present on MEL.A cells and not on MEL.B.
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