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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

CD27 molecule

CD27, T14
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CD8, CAN, HAD, CD19
Papers using CD27 antibodies
FoxM1 is required for execution of the mitotic programme and chromosome stability.
Mosley R., In PLoS ONE, 2004
... Glostrup, Denmark); FITC-conjugated anti-CD3, PE-labeled anti-CD4, and FITC-labeled anti-CD4 (Sigma-Aldrich, Taufkirchen, Germany); PE-labeled anti-CD25, FITC-labeled anti-CD27, FITC-labeled anti-CD45RA, and PE-labeled anti-CD45RO (BD Bioscience, Heidelberg, Germany); polyclonal goat anti-mouse immunoglobulin (Ig) (MP Biomedicals, Solon, OH); sheep red ...
Defective B cell tolerance checkpoints in systemic lupus erythematosus
Nussenzweig Michel C. et al., In The Journal of Experimental Medicine, 2003
... and CD10-depleted B cell fractions were stained with anti–human CD19-APC, anti–human CD10-PE, anti–human IgM-biotin, and anti–human CD27-FITC antibodies (BD Biosciences), and biotinylated anti–human IgM ...
Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence
López-Larrea Carlos et al., In Age, 2002
... Germany) and stained with anti-CD45RA (FITC; Immunostep, Salamanca, Spain), anti-CCR7 (Alexa Fluor 647; BD Bioscience), anti-CD27 (PE; Immunostep) and anti-CD28 (PerCP; BD ...
Silencing of B Cell Receptor Signals in Human Naive B Cells
Müschen Markus et al., In The Journal of Experimental Medicine, 1996
... memory B cells were isolated from peripheral blood using anti-CD19 and anti-CD27 immunomagnetic beads (Miltenyi Biotec) as described ( ...
Papers on CD27
NK Cell-Specific Gata3 Ablation Identifies the Maturation Program Required for Bone Marrow Exit and Control of Proliferation.
Lee et al., Ottawa, Canada. In J Immunol, Feb 2016
Using NKp46-Cre-Gata3(fl/fl) mice in which Gata3 deficiency was induced as early as the immature stage of NK cell differentiation, we demonstrated that GATA3 is required for the NK cell maturation beyond the CD27 single-positive stage and is indispensable for the maintenance of liver-resident NK cells.
Genetic Influence on the Peripheral Blood CD4+ T-cell Differentiation Status in CMV Infection.
Derhovanessian et al., Tübingen, Germany. In J Gerontol A Biol Sci Med Sci, Feb 2016
For further testing, we have analyzed middle-aged monozygotic (MZ, n = 42) and dizygotic (DZ, n = 39) twin pairs from the Danish Twin Registry for their T-cell differentiation status, assessed by surface expression of CD27, CD28, CD57, and KLRG-1.
Distinctions among Circulating Antibody-Secreting Cell Populations, Including B-1 Cells, in Human Adult Peripheral Blood.
Rothstein et al., Havana, Cuba. In J Immunol, Feb 2016
In addition to B-1 (CD20(+)CD27(+)CD38(lo/int)CD43(+)) cell and conventional plasmablast (PB) (CD20-CD27(hi)CD38(hi)) cell populations, in this study, we identified a novel B cell population termed 20(+)38(hi) B cells (CD20(+)CD27(hi)CD38(hi)) that spontaneously secretes Ab.
Improved monitoring of clinical response in Systemic Lupus Erythematosus by longitudinal trend in soluble vascular cell adhesion molecule-1.
D'Cruz et al., London, United Kingdom. In Arthritis Res Ther, Dec 2015
sVCAM-1 levels were significantly correlated with CD95(+)CD27(+) activated memory B cells, CD95(+) plasmablasts and circulating plasma cell numbers in SLE patients.
Molecular characterization of HCMV-specific immune responses: Parallels between CD8(+) T cells, CD4(+) T cells, and NK cells.
van Gisbergen et al., Amsterdam, Netherlands. In Eur J Immunol, Sep 2015
The HCMV-specific CD8(+) T-cell response is characterized by the accumulation of terminally differentiated effector cells that have downregulated the costimulatory molecules CD27 and CD28.
The CD27-CD70 pathway and pathogenesis of autoimmune disease.
Bottaro et al., Camden, United States. In Semin Arthritis Rheum, Sep 2015
OBJECTIVE: To critically examine current evidence regarding the role of the CD27-CD70 pathway in the pathophysiology of autoimmune disease with a focus on understanding the contributions of this pathway as a potential new therapeutic target for systemic lupus erythematosus and rheumatoid arthritis.
Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS.
Melero et al., Pamplona, Spain. In Semin Oncol, Aug 2015
Co-stimulatory receptors include surface moieties that are constitutively expressed on resting lymphocytes such as CD28 or CD27 and others whose expression is induced upon recent previous antigen priming, ie, CD137, GITR, OX40, and ICOS.
[Immunological Aspects in Oncology--Circulating γδ T Cells].
Dubská et al., In Klin Onkol, 2014
Detailed immunophenotyping was also conducted describing representation of memory subsets (using CD45RO and CD27 markers) and presence of surface markers HLADr, CD69, CD25, CD28, CCR7, CTLA 4, ICOS, PD 1L and PD 1 between γδ T cells of the controls and breast carcinoma patients.
Primary Immunodeficiencies Associated with EBV Disease.
Cohen, Bethesda, United States. In Curr Top Microbiol Immunol, 2014
These include mutations in SH2D1A, BIRC4, ITK, CD27, MAGT1, CORO1A, and LRBA.
Comparison of cytokine expressions in acute myocardial infarction and stable angina stages of coronary artery disease.
Ding et al., Shanghai, China. In Int J Clin Exp Med, 2014
RESULTS: Compared with SA patients and the controls respectively, in AMI patients, IFNα2, IFNαR1, IFNαR2, IFNγR1, IFNγR2, L1β, IL16, IL18, Cxcl1, Cxcl2, Cxcl6, CxcR2, CxcR4, LIGHT, TNFR1, LT-βR, CD137, TRAILR, and TWEAKR mRNA expressions were significantly up-regulated (P<0.05), while Ccl5, Ccl24, Ccl28, CcR5, TWEAK, CD40, CD27, and BAFFR mRNA expressions were significantly down-regulated (P<0.05).
Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8(+) T cells.
Randall et al., Birmingham, United States. In Immunity, 2014
As a consequence, they maintained CD25 expression and responded to interleukin-2 (IL-2) and CD27, which together programmed their robust secondary proliferative capacity and interferon-γ (IFN-γ)-producing ability.
The inhibitory receptor BTLA controls γδ T cell homeostasis and inflammatory responses.
Ware et al., Los Angeles, United States. In Immunity, 2014
BTLA expression limited γδ T cell numbers and sustained normal γδ T cell subset frequencies by restricting IL-7 responsiveness and expansion of the CD27(-)RORγt(+) population.
Epigenetic modifications induced by Blimp-1 Regulate CD8⁺ T cell memory progression during acute virus infection.
Berg et al., Worcester, United States. In Immunity, 2013
We found that increased proliferation and survival of Blimp-1-deficient CD8⁺ T cells resulted from sustained expression of CD25 and CD27 and persistent cytokine responsiveness.
Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets.
Silva-Santos et al., Lisbon, Portugal. In Nat Immunol, 2013
Two distinct subsets of γδ T cells that produce interleukin 17 (IL-17) (CD27(-) γδ T cells) or interferon-γ (IFN-γ) (CD27(+) γδ T cells) develop in the mouse thymus, but the molecular determinants of their functional potential in the periphery remain unknown.
Effector-like CD8⁺ T cells in the memory population mediate potent protective immunity.
Hamilton et al., Minneapolis, United States. In Immunity, 2013
We show that a population of CD8⁺ T cells bearing markers associated with effector cells (KLRG1(hi), CD27(lo), T-bet(hi), Eomes(lo)) persisted to the memory phase and provided optimal control of Listeria monocytogenes and vaccinia virus, despite weak recall proliferative responses.
Association of CD27 and CD70 gene polymorphisms with risk of sporadic breast cancer in Chinese women in Heilongjiang Province.
Li et al., Harbin, China. In Breast Cancer Res Treat, 2012
These results indicate that CD27 and CD70 gene polymorphisms may affect the risk of breast cancer and show that some SNPs are associated with breast cancer characteristics in a northern Chinese population.
CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia.
Tesselaar et al., Utrecht, Netherlands. In J Allergy Clin Immunol, 2012
gene deficiency is associated with combined immunodeficiency and symptomatic EBV viremia
CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression.
Ochsenbein et al., Bern, Switzerland. In J Clin Invest, 2012
Data show that in a mouse model of chronic myelogenous leukemia, BCR/ABL+ leukemia stem and progenitor cells express CD27, and reveal a mechanism by which adaptive immunity contributes to leukemia progression.
Decreased CD27 on B lymphocytes in patients with primary hepatocellular carcinoma.
Fang et al., Changchun, China. In J Int Med Res, 2011
Decreased CD27 on B lymphocytes in patients with primary hepatocellular carcinoma.
The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions.
Schoenberger et al., Los Angeles, United States. In Nat Commun, 2011
The CD4+ T-cell help signal is transmitted from APC to CD8+ T-cells via CD27-CD70 interactions.
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