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Membrane-spanning 4-domains, subfamily A, member 1

CD20, CK20, cytokeratin 20, Keratin-20
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, cytokeratin, CD4
Papers using CD20 antibodies
Distinguishing direct from indirect roles for bicoid mRNA localization factors.
Marrack Philippa, In PLoS Biology, 2009
... For CD16 mediated cytotoxicity Daudi target cells were first labelled with 0.1 µg anti-CD20, for 15 min, at 37°C.Primary human NK cells were isolated from healthy donor peripheral blood under negative magnetic selection (NK cell isolation kit; Miltenyi Biotec) and cultured as previously ...
The importance of angiogenesis markers in the outcome of patients with diffuse large B cell lymphoma: a retrospective study of 97 patients
Lekhakula Arnuparp et al., In The Scientific World Journal, 2007
... Monoclonal antibodies targeting CD3, CD5, CD20, and CD79a (Dako, Glostrup, Denmark) were used ...
Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma
Delabie Jan et al., In Journal of Hematopathology, 2007
... CD20 (L-26)DAKO Cytomation, Denmark A/S ...
Differential diagnosis of primary versus metastatic pulmonary adenocarcinomas using gene mutation analyses: a case report
Allan Robert W. et al., In Case Reports in Pathology, 2007
... 8G7G3/1 clone, Cell Marque, Rocklin, CA, USA), cytokeratin 7 (OV-TL clone, Dako, Carpinteria, CA, USA), and cytokeratin 20 (K520.8
A case of primary small cell carcinoma of the breast
Bergkvist Leif et al., In Pathology Research International, 2006
... 1 : 3000), high molecular weight cytokeratin (CK; Dako, clone 34BE12, 1 : 150), CK8/18 (Novocastra, clone 5D3, 1 : 50), CK20 (Dako, clone Ks20.8, 1 : 100), CK7 ...
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Papers on CD20
B cell-directed therapies in multiple sclerosis.
Hemmer et al., München, Germany. In Neurodegener Dis Manag, Feb 2016
Three therapeutic monoclonal antibodies targeting CD20-positive B cells (rituximab, ocrelizumab and ofatumumab) were investigated in MRI-based Phase II and Phase III trials in RRMS, providing consistent evidence for a disease-ameliorating effect of B cell depleting therapies in MS.
Immunohistochemistry of ductal adenocarcinoma of the prostate and adenocarcinomas of non-prostatic origin: a comparative study.
Egevad et al., Stockholm, Sweden. In Apmis, Feb 2016
Slides were stained for estrogen, progesterone and androgen receptor, prolactin, PSA, prostein, PSMA, PSAP, CDX2, lysozyme, villin, monoclonal CEA, CK7, CK20, HMWCK, p63, p504s, c-Myc, EGFR, Ki-67, p16, p21, p27, p53, PTEN, ERG, and PAX-8.
Extranodal NK/T-cell lymphoma, nasal type, manifesting as rapidly progressive dementia without any mass or enhancing brain lesion.
Kaji et al., Tokushima, Japan. In Neuropathology, Feb 2016
Cells were positive for CD3, CD56 and EBV-encoded small RNAs and negative for CD20.
Hypersensitivity reactions during treatment with biological agents.
Migliorini et al., Pisa, Italy. In Clin Exp Rheumatol, Feb 2016
UNASSIGNED: The recent development of biological agents, namely, anti-tumour necrosis factor alpha (TNF-α) agents (infliximab, adalimumab and etanercept), anti- CD20 monoclonal antibody (rituximab) and anti-interleukin 6 receptor (IL-6R) monoclonal antibody (tocilizumab), represents a major breakthrough for the treatment of immune-mediated disorders.
The role of Fc-receptors in the uptake and transport of therapeutic antibodies in the retinal pigment epithelium.
Klettner et al., Kiel, Germany. In Exp Eye Res, Feb 2016
In this study, we investigated the involvement of Fc-receptors, both Fcγ-receptors and the neonatal Fc-receptor (FcRn) in the uptake and intracellular trafficking of the VEGF-antagonists bevacizumab, aflibercept and the anti-CD20 antibody rituximab in three different model systems, primary porcine RPE cells, ARPE-19 cells and porcine RPE/choroid explants.
Ibrutinib in combination with rituximab in relapsed or refractory mantle cell lymphoma: a single-centre, open-label, phase 2 trial.
Zhang et al., Houston, United States. In Lancet Oncol, Jan 2016
METHODS: Patients with a confirmed mantle cell lymphoma diagnosis (based on CD20-positive and cyclin D1-positive cells in tissue biopsy specimens), no upper limit on the number of previous treatments received, and an Eastern Cooperative Oncology Group performance status score of 2 or less were enrolled in this single-centre, open-label, phase 2 study.
The potential role for ocrelizumab in the treatment of multiple sclerosis: current evidence and future prospects.
Blinkenberg et al., Copenhagen, Denmark. In Ther Adv Neurol Disord, Jan 2016
Ocrelizumab, a second-generation humanized anti-CD20 antibody, was explored in a large phase II, randomized, placebo-controlled multicentre trial in patients with relapsing-remitting disease.
Small Cell Carcinoma of the Urinary Bladder: KIT and PDGFRA Gene Mutations.
Kozacioğlu et al., İzmir, Turkey. In Rare Tumors, Jan 2016
The tumor cells were negative for CK7, CK20, CD3, CD20, LCA, CDX2, uroplakin, thyroid transcription factor 1, PSA and p63.
Targeted therapies for CLL: Practical issues with the changing treatment paradigm.
O'Brien et al., Houston, United States. In Blood Rev, Jan 2016
These include B-cell receptor (BCR) inhibitors such as Bruton tyrosine kinase (BTK) inhibitors, PI3 kinase inhibitors, and Syk inhibitors, novel anti-CD20 monoclonal antibodies such as ofatumumab and obinutuzumab, and Bcl-2 antagonists such as venetoclax (ABT-199).
B-cell and T-cell quantification in minor salivary glands in primary Sjögren's syndrome: development and validation of a pixel-based digital procedure.
Devauchelle-Pensec et al., Brest, France. In Arthritis Res Ther, Dec 2015
METHODS: Minor salivary gland biopsies were immunostained with anti-CD20/anti-CD3 antibodies using red/brown chromogens.
Lenalidomide plus Rituximab as Initial Treatment for Mantle-Cell Lymphoma.
Leonard et al., Nigeria. In N Engl J Med, Dec 2015
Lenalidomide, an immunomodulatory compound, and rituximab, an anti-CD20 antibody, are active in patients with recurrent mantle-cell lymphoma.
Randomized Phase II Trial Comparing Obinutuzumab (GA101) With Rituximab in Patients With Relapsed CD20+ Indolent B-Cell Non-Hodgkin Lymphoma: Final Analysis of the GAUSS Study.
Press et al., Vancouver, Canada. In J Clin Oncol, Nov 2015
PURPOSE: Obinutuzumab (GA101), a novel glycoengineered type II anti-CD20 monoclonal antibody, demonstrated responses in single-arm studies of patients with relapsed/refractory non-Hodgkin lymphoma.
Ofatumumab maintenance versus observation in relapsed chronic lymphocytic leukaemia (PROLONG): an open-label, multicentre, randomised phase 3 study.
PROLONG study investigators et al., Amsterdam, Netherlands. In Lancet Oncol, Oct 2015
BACKGROUND: Ofatumumab is a human anti-CD20 monoclonal antibody that has proven efficacy as monotherapy in refractory chronic lymphocytic leukaemia.
Targeting indirect pathway CD4 T-cell alloresponses in the prevention of chronic transplant rejection.
Pettigrew et al., Cambridge, United Kingdom. In Lancet, Mar 2015
Antigen presentation by dendritic cells and B cells was assessed by selective depletion with diphtheria toxin or depleting anti-CD20 monoclonal antibody.
Effector B cells in autoimmune diseases.
Niiro, In Nihon Rinsho Meneki Gakkai Kaishi, 2014
Given risk/benefit considerations, a novel strategy to selectively target the function of effector B cells would be more preferable than the nonselective B-cell depletion achieved by anti-CD20 therapy in AID.
Histomorphologic and molecular features of pouch and peripouch adenocarcinoma: a comparison with ulcerative colitis-associated adenocarcinoma.
Liu et al., Cleveland, United States. In Am J Surg Pathol, 2012
Pouch/peripouch and UC-associated adenocarcinoma had a comparable positive rate for CK7, CK20, and CDX2 by immunohistochemistry.
The dual effects of B cell depletion on antigen-specific T cells in BDC2.5NOD mice.
Wen et al., New Haven, United States. In J Immunol, 2012
B-cell depletion induces transient aggressive behavior in BDC2.5 diabetogenic T cells and reduction in regulatory T (Treg) cell number and function during the B-cell depletion period.
Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50. Proc. Natl. Acad. Sci. 1986. 83: 4494-4498.
Ledbetter et al., In J Immunol, 2012
Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.
CK19, CK20, EGFR and HER2 status of circulating tumor cells in patients with breast cancer.
Evrensel et al., Bursa, Turkey. In Tumori, 2012
Results suggest that CK20 mRNA with other biomarkers in the peripheral blood of breast cancer patients may be useful to monitor the presence of disseminated tumor cells in the blood circulation and to predict the prognosis of breast cancer.
MS4A1 dysregulation in asbestos-related lung squamous cell carcinoma is due to CD20 stromal lymphocyte expression.
Fong et al., Australia. In Plos One, 2011
Dsta show that differential expression of MS4A1 is a stromal signal of uncertain significance, and an example of the rationale for tumor cell enrichment in preparation for gene expression studies to identify markers of particular tumor phenotypes.
More papers using CD20 antibodies
Follicular dendritic cell sarcoma in the lymph nodes of the neck
Adam Patrick et al., In Diagnostic Pathology, 2006
... CD20DAKO ...
Primary dural lymphoma: a clinicopathologic study of treatment and outcome in eight patients
Chan Wing C. et al., In Journal of Hematopathology, 2005
... CD20L26Dako ...
Neurological disease in HIV-infected patients in the era of highly active antiretroviral treatment: a Brazilian experience
Adad Sheila Jorge et al., In AIDS Research and Treatment, 2005
... and II), JC virus (Novocastra-NCL-JCBK) and for characterization of lymphoma: CD3 (Dako-CD3-Leu, T3), CD20 (Novocastra, NCL-CD20-L26), CD 30 (Dako-CD30 Ber-H2), CD45 (Dako CD45RO-UCHL1), ...
Cytotoxic T-cell non-Hodgkin's lymphoma of the thyroid gland
Lee Young-Don et al., In Journal of Korean Medical Science, 2004
... Immunohistochemistry was done by avidin-biotin-peroxidase complex methods using antibodies against CD3 (Dako, Glostrup, Denmark, prediluted), CD20 (Dako, prediluted), CD4 (Dako, prediluted), ...
Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis
Masawa Nobuhide et al., In Head and Neck Pathology, 2004
... (Novocastra, Newcastle, UK), PS-1 (CD3; Immunotech, Marseille, France), 4C7 (CD5; Novocastra), 56C6 (CD10; Novocastra), L26 (CD20; Dako A/S, Glostrup, Denmark), 1B12 ...
De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients
Stein Harald et al., In Virchows Archiv, 2001
... CD20L26Citrate1:50Dako ...
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
Sriplung Hutcha et al., In ISRN Oncology, 2001
... For lymphoma immunophenotyping, monoclonal antibodies targeting CD3, CD5, CD20, and CD79a (Dako, Glostrup, Denmark) were used ...
MUC gene expression and histogenesis of adenocarcinoma of the stomach
Yano Seiji et al., In Diagnostic Pathology, 2000
... panel: monoclonal antibodies to cytokeratin 7 (CK7, OV-TL12/30, dilution 1:100; Dako Cytomation, Carpinteria, CA), cytokeratin 20 (CK20, Ks20.8, dilution 1:50; Dako Cytomation), apomucin MUC1 (clone ...
Neuron count reevaluation in the myenteric plexus of chagasic megacolon after morphometric neuron analysis
Adad Sheila Jorge et al., In Journal of Tropical Medicine, 2000
... Immunohistochemistry (polymers technique) was performed for anti-CD20 (DAKO, dilution 1 : 600, clone: L26, ...
Regulation of CD30 antigen expression and its potential significance for human disease
Papadopoulos Nikolas et al., In Theoretical Biology & Medical Modelling, 1999
... activated lymphoid cells, mouse monoclonal antibody (Novocastra); (CD45/LCA) leukocyte common antigen, mouse monoclonal antibody (Dako); (CD20/L-26) B-lymphocytes, mouse monoclonal antibody (Dako); and (CD3) T-lymphocytes, mouse ...
Human Dendritic Cells Activated by TSLP and CD40L Induce Proallergic Cytotoxic T Cells
Liu Yong-Jun et al., In The Journal of Experimental Medicine, 1999
... were further stained with PE-Cy5–conjugated anti-CD4 (Caltag), PE-conjugated anti-CD11c and FITC-conjugated anti-CD3, CD14, CD16, and CD20 (all Becton Dickinson). A Service of the U.S. National Institute of Health
Winer Eric et al., In Journal of Hematology & Oncology, 1996
... 1:400), CD4 (Novocastra, Newcastle upon Tyne, UK; dilution 1:20), CD56 (Sanbio, Uden, The Netherlands; 1:200), CD20 (Dako; dilution 1:100), CD79a (Dako; ...
Effects of influenza A nucleoprotein on polymorphonuclear neutrophil function
Rabourdin-Combe Chantal et al., In The Journal of Experimental Medicine, 1995
... were routinely >98% and >90% pure, respectively, as revealed by their pattern of expression of CD20 and CD3 (Dako, Trappes, France) ...
Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity
van Noesel Carel J.M. et al., In The Journal of Experimental Medicine, 1988
... Monoclonal antibodies used: IgM, κ- and λ-light chains (Becton Dickinson), IgG, IgA, CD20 (L26; DakoCytomation), CXCR3 (1C6; BD Biosciences), and α4β7 (Act-1).
Skeletal complications in hairy cell leukemia: diagnosis and therapy
Sohani Aliyah R. et al., In Journal of Hematopathology, 1987
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