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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Killer cell lectin-like receptor subfamily B, member 1

CD161, NK3 receptor, NKR-P1, NKR, NKR-P1A
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CAN, CD8, CD94, HAD
Papers on CD161
MAIT cells in autoimmunity, immune mediated diseases and airways disease.
Hinks, Melbourne, Australia. In Immunology, Feb 2016
However MAIT cells have a specific sensitivity to suppression by therapeutic corticosteroids that may confound many of these observations, as may the tendency of the surface marker CD161 to activation-induced down-regulation.
The evolution of natural killer cell receptors.
de Boer et al., Utrecht, Netherlands. In Immunogenetics, Jan 2016
Thus, NKR haplotypes contain several genes encoding for receptors with activating and inhibiting signaling, and that vary in gene content and allelic polymorphism.
Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis.
Calabresi et al., Baltimore, United States. In Neurology, Jan 2016
In the high-dose group, we found a reduction in the proportion of interleukin-17(+)CD4(+) T cells (p = 0.016), CD161(+)CD4(+) T cells (p = 0.03), and effector memory CD4(+) T cells (p = 0.021) with a concomitant increase in the proportion of central memory CD4(+) T cells (p = 0.018) and naive CD4(+) T cells (p = 0.04).
Peripheral loss of CD8(+) CD161(++) TCRVα7.2(+) MAIT cells in chronic HCV-infected patients.
Shankar et al., Kuala Lumpur, Malaysia. In Eur J Clin Invest, Jan 2016
MATERIALS AND METHODS: We investigated the frequency of CD8(+) CD161(++) TCR Vα7.2(+) MAIT cells in a cross-sectional cohort of chronic HCV patients (n=25) and healthy controls (n=25).
The NK3 receptor antagonist ESN364 suppresses sex hormones in men and women.
Combalbert et al., Belgium. In J Clin Endocrinol Metab, Jan 2016
NK3 receptor antagonism modulates this axis with distinct pharmacology compared to existing therapies.
Parallel assessment of Th17 cell frequencies by surface marker co-expression versus ex vivo IL-17 production in HIV-1 infection.
Zur Wiesch et al., Hamburg, Germany. In Cytometry B Clin Cytom, Jan 2016
METHODS: Cryopreserved PBMCs from healthy controls and HIV infected subjects, including treated (cART) and viremic patients, were split and analyzed side by side by flow cytometry for expression of surface markers CCR6, CXCR3, CCR4 and CD161, or for intracellular expression of IL-17A and IFNγ after stimulation.
Preliminary Report of a Neurokinin-Like Receptor Gene Sequence for the Nemertean Paranemertes sp.
Okazaki et al., Ogden, United States. In Zoolog Sci, Dec 2015
TKs require the expression of at least one of three receptor subtypes: Neurokinin Receptor-1 (NKR-1), Neurokinin Receptor-2 (NKR-2), or Neurokinin Receptor-3 (NKR-3).
An Endogenous Tachykinergic NK2/NK3 Receptor Cascade System Controlling the Release of Serotonin from Colonic Mucosa.
Anzai et al., Mibu, Japan. In Curr Neuropharmacol, Dec 2015
Our in vitro studies in guinea-pig colon have indicated that the cascade pathway of neuronal tachykinergic NK3 receptors and NK2 receptors on peptide YY (PYY)-containing endocrine L cells represents an endogenous modulator system for 5-HT release from EC cells and that melatonin, endogenous tachykinins and PYY play important roles in modulation of the release of 5-HT from EC cells via the endogenous NK2/NK3 receptor cascade system.
Beyond ecto-nucleotidase: CD39 defines human Th17 cells with CD161.
Robson et al., Nanchang, China. In Purinergic Signal, Sep 2015
We have recently found in addition that co-expression of CD39 and CD161 by human CD4(+) T cells may become a biomarker of human Th17 cells.
The prognostic landscape of genes and infiltrating immune cells across human cancers.
Alizadeh et al., Stanford, United States. In Nat Med, Aug 2015
By using this resource, we identified a forkhead box MI (FOXM1) regulatory network as a major predictor of adverse outcomes, and we found that expression of favorably prognostic genes, including KLRB1 (encoding CD161), largely reflect tumor-associated leukocytes.
Natural killer cell maturation markers in the human liver and expansion of an NKG2C+KIR+ population.
Khakoo et al., Southampton, United Kingdom. In Lancet, Mar 2015
Mononuclear cells were isolated by ficoll separation and cell surface staining performed for CD3, CD56, CD16, CD57, CD117, CD161, CD158a, CD158b, CD49a, CD49b, CXCR6, NKG2C, and NKp46.
Neuropeptide Receptor Ligands for the Treatment of Schizophrenia: Focus on Neurotensin and Tachykinins.
Griebel, Chilly-Mazarin, France. In Curr Pharm Des, 2014
However, clinical studies with notably selective tachykinin NK3 receptor antagonists in schizophrenia have been disappointing, and they were unable to confirm the promising therapeutic potential from animal studies, thereby questioning the therapeutic utility of these compounds for this condition.
Expansion of functional human mucosal-associated invariant T cells via reprogramming to pluripotency and redifferentiation.
Fujita et al., Sapporo, Japan. In Cell Stem Cell, 2013
Under T cell-permissive conditions, these iPSCs efficiently redifferentiate into MAIT-like lymphocytes expressing the T cell receptor Vα7.2, CD161, and interleukin-18 receptor chain α.
Gene deregulation and chronic activation in natural killer cells deficient in the transcription factor ETS1.
Kee et al., Chicago, United States. In Immunity, 2012
ETS1 functions at the earliest stages of NK cell development to promote expression of critical transcriptional regulators including T-BET and ID2, NK cell receptors (NKRs) including NKp46, Ly49H, and Ly49D, and signaling molecules essential for NKR function.
Analysis of the expression of neurokinin B, kisspeptin, and their cognate receptors NK3R and KISS1R in the human female genital tract.
Candenas et al., Sevilla, Spain. In Fertil Steril, 2012
NKB/NK(3)R and kisspeptin/KISS1R are present in female peripheral reproductive tissues with colocalization of both systems in some non-neuronal cell populations of the human female genital tract.
Uncovering novel reproductive defects in neurokinin B receptor null mice: closing the gap between mice and men.
Seminara et al., Boston, United States. In Endocrinology, 2012
although capable of fertility, Tacr3-deficient mice have central reproductive defects
Role of neurokinin B in the control of female puberty and its modulation by metabolic status.
Tena-Sempere et al., Córdoba, Spain. In J Neurosci, 2012
NKB-NK3R signaling plays a role in pubertal maturation; its alterations may contribute to pubertal disorders linked to metabolic stress and negative energy balance.
Structure of the H107R variant of the extracellular domain of mouse NKR-P1A at 2.3 Å resolution.
Dohnálek et al., Praha, Czech Republic. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
structure of the H107R variant of the extracellular domain of the mouse natural killer cell receptor NKR-P1A has been determined by X-ray diffraction at 2.3 A resolution from a merohedrally twinned crystal
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.
Spits et al., Amsterdam, Netherlands. In Nat Immunol, 2011
expression defines IL-25- and IL-33-responsive type 2 innate lymphoid cells
Normosmic congenital hypogonadotropic hypogonadism due to TAC3/TACR3 mutations: characterization of neuroendocrine phenotypes and novel mutations.
Young et al., Le Kremlin-Bicêtre, France. In Plos One, 2010
The gonadotropin axis dysfunction associated with nCHH due to TAC3/TACR3 mutations is related to a low GnRH pulsatile frequency leading to a low frequency of alpha-subunit pulses and to an elevated FSH/LH ratio.
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